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MX9707585A - Mezclas homogeneas de farmacos y aditivos de fusion a baja temperatura para liberacion controlada. - Google Patents

Mezclas homogeneas de farmacos y aditivos de fusion a baja temperatura para liberacion controlada.

Info

Publication number
MX9707585A
MX9707585A MX9707585A MX9707585A MX9707585A MX 9707585 A MX9707585 A MX 9707585A MX 9707585 A MX9707585 A MX 9707585A MX 9707585 A MX9707585 A MX 9707585A MX 9707585 A MX9707585 A MX 9707585A
Authority
MX
Mexico
Prior art keywords
drug
low temperature
additive
additives
controlled release
Prior art date
Application number
MX9707585A
Other languages
English (en)
Inventor
Howard CHESKIN
Thomas J Hale
Kurt G Van Scoik
Ji Zhou
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX9707585A publication Critical patent/MX9707585A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una formulacion de liberacion controlada que comprende, en combinacion, una dosis de fármaco terapéuticamente activa, la cual se funde a baja temperatura y un aditivo seleccionado del grupo que consiste de etil celulosa, metilcelulosa, hidroxipropil celulosa, poliacilamida, copolímero de etilaeno-acetato de vinilo, metacrilato de polimetilo, metacrilato depolihidroxietilo y ceras, y similares, de manera que el aditivo y el fármaco forman un material compuesto homogéneo de fármaco-aditivo con un 92 a 97%, peso/peso, de dicho fármaco se selecciona del grupo que consiste de: divalproex de hidrogeno de sodio, ibuprofen, ramipril, dibencilina, tetranitrato de aritritilo, dinatrato de isosorbida, metosuximida, cetoprofen, gemfibrozil, clorhidrato de paroxetina, y maleato de trimipramina.
MX9707585A 1995-04-03 1996-04-02 Mezclas homogeneas de farmacos y aditivos de fusion a baja temperatura para liberacion controlada. MX9707585A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41540195A 1995-04-03 1995-04-03
PCT/US1996/004513 WO1996031197A1 (en) 1995-04-03 1996-04-02 Homogeneous mixtures of low temperature-melting drugs and additives for controlled release

Publications (1)

Publication Number Publication Date
MX9707585A true MX9707585A (es) 1997-12-31

Family

ID=23645549

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9707585A MX9707585A (es) 1995-04-03 1996-04-02 Mezclas homogeneas de farmacos y aditivos de fusion a baja temperatura para liberacion controlada.

Country Status (6)

Country Link
US (1) US5807574A (es)
EP (1) EP0818990A1 (es)
JP (1) JP3768536B2 (es)
CA (1) CA2216934A1 (es)
MX (1) MX9707585A (es)
WO (1) WO1996031197A1 (es)

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GB9514842D0 (en) * 1995-07-20 1995-09-20 Smithkline Beecham Plc Novel formulation
US6548084B2 (en) 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
TR200201156T2 (tr) 1997-06-10 2002-07-22 Synthon B.V. 4-Fenilpiperidin bileşimleri.
US5955475A (en) * 1997-06-30 1999-09-21 Endo Pharmaceuticals Inc. Process for manufacturing paroxetine solid dispersions
GB9724544D0 (en) * 1997-11-21 1998-01-21 Smithkline Beecham Plc Novel Formulation
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
GB9810180D0 (en) * 1998-05-13 1998-07-08 Smithkline Beecham Plc Novel formulation
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
ATE311883T1 (de) 1999-03-12 2005-12-15 Aesica Pharmaceuticals Ltd Stabile pharmazeutische anwendungsform für paroxetin-anhydrat
US6482440B2 (en) * 2000-09-21 2002-11-19 Phase 2 Discovery, Inc. Long acting antidepressant microparticles
US20020132010A1 (en) * 2000-12-22 2002-09-19 Yihong Qui Divalproex sodium dosage forms and a process for their production
US6610326B2 (en) 2001-02-16 2003-08-26 Andrx Corporation Divalproex sodium tablets
US20040105886A1 (en) * 2001-02-16 2004-06-03 Chih-Ming Chen Divalproex sodium tablets
WO2003037301A2 (en) * 2001-10-29 2003-05-08 King Pharmaceuticals Research And Development, Inc Oral dosage forms for improving the bioavailability of therapeutic agents
EP1620060B1 (en) * 2003-04-29 2010-03-24 The General Hospital Corporation Methods and devices for the sustained release of multiple drugs
ITMI20032399A1 (it) * 2003-12-09 2005-06-10 Zambon Spa Composizione farmaceutica contenente gabapentina.
WO2005067887A2 (en) 2004-03-24 2005-07-28 Actavis Group Formulations of ramipril
US20050266082A1 (en) * 2004-05-26 2005-12-01 Patel Satishkumar A Preparation of stable paroxetine HC1 ER tablets using a melt granulation process
US7713550B2 (en) * 2004-06-15 2010-05-11 Andrx Corporation Controlled release sodium valproate formulation
US20050276849A1 (en) * 2004-06-15 2005-12-15 Nilobon Podhipleux Sustained release dosage forms
US20050276848A1 (en) * 2004-06-15 2005-12-15 Nilobon Podhipleux Sustained release neutralized divalproex sodium
US20060039975A1 (en) * 2004-08-20 2006-02-23 Zalman Vilkov Paroxetine formulations
DE102005037630A1 (de) 2005-08-09 2007-02-15 Glatt Gmbh Verfahren zur Herstellung von Teilchen aus pharmazeutischen Substanzen, Teilchen aus pharmazeutischen Substanzen sowie deren Verwendung
US20070082046A1 (en) * 2005-10-11 2007-04-12 Banner Pharmacaps, Inc. Enteric valproic acid
GB0707127D0 (en) * 2007-04-13 2007-05-23 Zysis Ltd Pharmaceutical compositions
EP2042165A1 (de) * 2007-09-28 2009-04-01 Swiss Caps Rechte und Lizenzen AG Hot-Melt-Befüllte Weichkapseln
JP5858906B2 (ja) * 2009-05-04 2016-02-10 シヴィダ・ユーエス・インコーポレイテッドＰｓｉｖｉｄａ Ｕｓ， Ｉｎｃ． 多孔質シリコン薬物溶出粒子
RU2640918C2 (ru) 2010-11-01 2018-01-12 Псивида Юэс, Инк. Биоразлагаемые устройства на основе кремния для доставки терапевтических агентов
RU2705986C2 (ru) 2013-03-15 2019-11-13 Айпоинт Фармасьютикалз Юэс, Инк. Биоразлагаемые композиции на основе кремния для доставки терапевтических агентов

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Publication number Priority date Publication date Assignee Title
NL108838C (es) * 1956-03-27
US3279998A (en) * 1962-06-22 1966-10-18 Smith Kline French Lab Method of preparing sustained release tablets
DE3024416C2 (de) * 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
IL72381A (en) * 1983-07-20 1988-03-31 Sanofi Sa Pharmaceutical composition based on valproic acid
FR2549371B1 (fr) * 1983-07-20 1985-09-13 Sanofi Sa Nouvelle composition pharmaceutique contenant de l'acide valproique ou un de ses sels
US4913906B1 (en) * 1985-02-28 2000-06-06 Yissum Res Dev Co Controlled release dosage form of valproic acid
GB8716975D0 (en) * 1987-07-17 1987-08-26 Boots Co Plc Therapeutic agents
US5240712A (en) * 1987-07-17 1993-08-31 The Boots Company Plc Therapeutic agents
US4885175A (en) * 1987-12-23 1989-12-05 Wm. Wrigley Jr. Company Method of making chewing gum with wax-coated delayed release ingredients
FR2643556B1 (fr) * 1989-02-27 1993-03-05 Sanofi Sa Composition pharmaceutique a liberation prolongee d'acide valproique
WO1992001446A1 (en) * 1990-07-20 1992-02-06 Aps Research Limited Sustained-release formulations
JP2572673B2 (ja) * 1990-07-25 1997-01-16 エスエス製薬株式会社 徐放性錠剤
AU8404891A (en) * 1990-08-09 1992-03-02 Warner-Lambert Company Flavor delivery system with improved release and method of preparation
DE4031881C2 (de) * 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung
FR2682677A1 (fr) * 1991-10-17 1993-04-23 Sanofi Elf Complexe forme de l'acide propyl-2 pentene-2 ouique (e) et de son sel de sodium, sa preparation et compositions pharmaceutiques le contenant.
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations

Also Published As

Publication number Publication date
WO1996031197A1 (en) 1996-10-10
EP0818990A1 (en) 1998-01-21
JP3768536B2 (ja) 2006-04-19
CA2216934A1 (en) 1996-10-10
US5807574A (en) 1998-09-15
JPH11503163A (ja) 1999-03-23

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