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MX9702776A - Use of flea proteases and protease inhibitors to protect animals from flea infestation. - Google Patents

Use of flea proteases and protease inhibitors to protect animals from flea infestation.

Info

Publication number
MX9702776A
MX9702776A MX9702776A MX9702776A MX9702776A MX 9702776 A MX9702776 A MX 9702776A MX 9702776 A MX9702776 A MX 9702776A MX 9702776 A MX9702776 A MX 9702776A MX 9702776 A MX9702776 A MX 9702776A
Authority
MX
Mexico
Prior art keywords
flea
proteins
infestation
protease inhibitors
proteases
Prior art date
Application number
MX9702776A
Other languages
Spanish (es)
Inventor
Robert B Grieve
Keith E Rushlow
Shirly Wu Hunter
Glenn R Frank
Gary L Stiegler
Miles Yamanaka
Ann Arfsten
Beverly Dale
Andrew Heath
Original Assignee
Heska Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/326,773 external-priority patent/US5766609A/en
Priority claimed from US08/484,211 external-priority patent/US5972645A/en
Priority claimed from US08/485,443 external-priority patent/US6146870A/en
Priority claimed from US08/482,130 external-priority patent/US5962257A/en
Priority claimed from US08/485,455 external-priority patent/US5712143A/en
Application filed by Heska Corp filed Critical Heska Corp
Publication of MX9702776A publication Critical patent/MX9702776A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6408—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/641—Cysteine endopeptidases (3.4.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to flea serine protease and aminopeptidase proteins; to flea serine protease and aminopeptidase nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or aminopeptidase activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
MX9702776A 1994-10-18 1997-04-16 Use of flea proteases and protease inhibitors to protect animals from flea infestation. MX9702776A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/326,773 US5766609A (en) 1991-12-13 1994-10-18 Use of protease inhibitors and protease vaccines to protect animals from flea infestation
US08/484,211 US5972645A (en) 1991-12-13 1995-06-07 Flea serine protease nucleic acid molecules
US08/485,443 US6146870A (en) 1991-12-13 1995-06-07 Flea protease proteins
US08/482,130 US5962257A (en) 1991-12-13 1995-06-07 Flea aminopeptidase nucleic acid molecules
US08/485,455 US5712143A (en) 1991-12-13 1995-06-07 Flea protease proteins, nucleic acid molecules, and uses thereof

Publications (1)

Publication Number Publication Date
MX9702776A true MX9702776A (en) 1998-07-31

Family

ID=27541069

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9702776A MX9702776A (en) 1994-10-18 1997-04-16 Use of flea proteases and protease inhibitors to protect animals from flea infestation.

Country Status (8)

Country Link
EP (1) EP0787014A4 (en)
JP (1) JPH10507455A (en)
AU (1) AU705715B2 (en)
CA (1) CA2202622A1 (en)
IL (1) IL115671A0 (en)
MX (1) MX9702776A (en)
NZ (1) NZ296424A (en)
WO (1) WO1996011706A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210920B1 (en) * 1991-12-13 2001-04-03 Heska Corporation Flea protease proteins, nucleic acid molecules, and uses thereof
WO1998045408A2 (en) * 1996-04-10 1998-10-15 Heska Corporation Novel ectoparasite saliva proteins and apparatus to collect such proteins
US6204010B1 (en) * 1995-06-07 2001-03-20 Heska Corporation Flea protease proteins, nucleic acid molecules, and uses thereof
FR2750865B1 (en) * 1996-06-27 1998-12-04 Rhone Merieux RECOMBINANT LIVING VACCINE BASED ON CANINE HERPESVIRUS, IN PARTICULAR FOR SQUARE DISEASE, RABIES OR TYPE 2 PARAINFLUENZA VIRUS
US6596291B2 (en) 1997-12-05 2003-07-22 Thomas A. Bell Compositions and methods for treating surfaces infected with ectoparasitic insects
EP1947112B1 (en) 1999-04-09 2012-05-16 Heska Corporation Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof
US6399759B1 (en) * 1999-05-27 2002-06-04 University Of Georgia Research Foundation, Inc. Ant proteases and methods of inhibition
US7812163B2 (en) 2003-07-16 2010-10-12 Hatchtech Pty Ltd. Methods and compositions for controlling ectoparasites
AU2003903686A0 (en) * 2003-07-16 2003-07-31 Hatchtech Pty Ltd Methods and compositions for controlling ectoparasites
JP4710001B2 (en) * 2005-03-09 2011-06-29 国立大学法人帯広畜産大学 Tick leucine aminopeptidase
KR101920541B1 (en) 2011-05-31 2018-11-20 허치슨 바이오필름 메디컬 솔루션스 리미티드 Dispersion and detachment of cell aggregates
AU2014377875B2 (en) 2013-12-17 2018-07-19 Dr. Reddy's Laboratories Sa Pediculicidal composition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356622A (en) * 1991-12-13 1994-10-18 Paravax, Inc. Flea midgut-supernatant vaccines

Also Published As

Publication number Publication date
NZ296424A (en) 1999-01-28
EP0787014A4 (en) 2001-01-10
IL115671A0 (en) 1996-01-19
EP0787014A1 (en) 1997-08-06
AU705715B2 (en) 1999-05-27
JPH10507455A (en) 1998-07-21
CA2202622A1 (en) 1996-04-25
WO1996011706A1 (en) 1996-04-25
AU4103896A (en) 1996-05-06

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