MX9700817A - Secuencia viral de nucleotidos de "vr-2332" y metodos de uso. - Google Patents
Secuencia viral de nucleotidos de "vr-2332" y metodos de uso.Info
- Publication number
- MX9700817A MX9700817A MX9700817A MX9700817A MX9700817A MX 9700817 A MX9700817 A MX 9700817A MX 9700817 A MX9700817 A MX 9700817A MX 9700817 A MX9700817 A MX 9700817A MX 9700817 A MX9700817 A MX 9700817A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleotide sequence
- methods
- sequences
- viral nucleotide
- nucleotide
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title abstract 3
- 125000003729 nucleotide group Chemical group 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 title 1
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 238000012408 PCR amplification Methods 0.000 abstract 1
- 108010067390 Viral Proteins Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se proporciona una secuencia viral de nucleotidos del virus VR-2332, la cual es capaz de producir el síndrome reproductivo y respiratorio porcino. La secuencia de nucleotidos incluye regiones que codifican para proteína las cuales se insertan en vectores recombinantes de la expresion en huésped de proteínas virales de acuerdo con una variedad de técnicas de vacunacion. Los ensayos diagnosticos utilizan secuencias fragmentarias de oligonucleotidos para identificar selectivamente los ácidos nucleicos de VR-2332 mediante hibridizacion o reacciones de amplificacion por PCR que diferencían a las secuencias de nucleotido de VR-2332 de otros virus causantes de PRRS, los cuales son inmunologicamente diferentes de VR-2332.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28794194A | 1994-08-05 | 1994-08-05 | |
PCT/US1995/009927 WO1996004010A1 (en) | 1994-08-05 | 1995-08-04 | Vr-2332 viral nucleotide sequence and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9700817A true MX9700817A (es) | 1997-05-31 |
Family
ID=23105037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9700817A MX9700817A (es) | 1994-08-05 | 1995-08-04 | Secuencia viral de nucleotidos de "vr-2332" y metodos de uso. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5998601A (es) |
EP (2) | EP1704869A1 (es) |
JP (1) | JP3748887B2 (es) |
AT (1) | ATE329616T1 (es) |
CA (1) | CA2196555C (es) |
DE (1) | DE69535061T2 (es) |
DK (1) | DK0783321T3 (es) |
ES (1) | ES2262142T3 (es) |
MX (1) | MX9700817A (es) |
PT (1) | PT783321E (es) |
WO (1) | WO1996004010A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9202724A (es) | 1991-06-06 | 1992-12-31 | Stichting Centr Diergeneeskund | Composicion que comprende un vector recombinante del agente lelystad y vacuna que comprende la misma. |
US5695766A (en) | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
US6773908B1 (en) * | 1992-10-30 | 2004-08-10 | Iowa State University Research Foundation, Inc. | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) |
US6592873B1 (en) | 1992-10-30 | 2003-07-15 | Iowa State University Research Foundation, Inc. | Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids |
US6380376B1 (en) | 1992-10-30 | 2002-04-30 | Iowa State University Research Foundation | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) |
EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
WO2000053787A1 (en) | 1999-03-08 | 2000-09-14 | Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. | Prrsv vaccines |
US20040224327A1 (en) * | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
RU2220978C2 (ru) * | 1997-05-06 | 2004-01-10 | Стихтинг Динст Ландбаувкюндиг Ондерзук | Пептид, индуцирующий образование антител, которые реагируют с двумя различными изолятами вррсс (варианты), иммуногенная композиция, вакцина для профилактики заражения репродуктивно-респираторным синдромом свиней, антитело, диагностический набор (варианты) |
AU7960598A (en) * | 1997-06-05 | 1998-12-21 | Origen, Inc. | Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine |
DE19836559A1 (de) * | 1998-08-12 | 2000-03-23 | Antigen Gmbh | Gefäß zur Entnahme von Blut |
NZ501264A (en) * | 1998-12-22 | 2001-09-28 | Pfizer Prod Inc | Polynucleotide DNA sequence encoding an infectious RNA molecule encoding a North American PRRS |
US7618797B2 (en) | 1998-12-22 | 2009-11-17 | Pfizer Inc | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
US7691389B2 (en) | 1998-12-22 | 2010-04-06 | Pfizer Inc | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
US7132106B2 (en) | 1998-12-22 | 2006-11-07 | Pfizer Inc. | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
EP2251419B1 (en) | 1999-04-22 | 2012-05-30 | United States Department of Agriculture | Porcine reproductive and respiratory syndrome vaccine, based on isolate JA-142 |
SK10932002A3 (sk) * | 2000-01-26 | 2002-11-06 | Boehringer Ingelheim Vetmedica Gmbh | Živý oslabený PRRS vírus obsahujúci ORF 1a, 1b a 2, nukleotidová sekvencia kódujúca vírus, spôsob generovania infekčného živého oslabeného PRRS vírusu, farmaceutický prostriedok s jeho obsahom a jeho použitie |
DE60121545T2 (de) | 2000-02-08 | 2007-06-28 | Regents Of The University Of Minnesota, Minneapolis | Virus des porcinen reproduktiven und respiratorischen syndroms und dessen verwendung |
EP1397498A1 (en) * | 2001-05-21 | 2004-03-17 | ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. | Delections in arterivirus replicons |
US6841364B2 (en) * | 2002-01-22 | 2005-01-11 | Protatek International, Inc. | Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof |
US20050170335A1 (en) * | 2003-10-09 | 2005-08-04 | Tetracore, Inc. | Detection of PRRSV |
MXPA06015105A (es) | 2004-06-18 | 2007-03-26 | Univ Minnesota | Identificacion de organismos viralmente infectados y vacunados. |
US7632636B2 (en) | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
CN101184997B (zh) * | 2005-02-25 | 2017-06-13 | 艾德克斯实验室公司 | 用于检测抗猪繁殖呼吸综合征病毒抗体的肽 |
EP2369001B1 (en) | 2005-06-24 | 2016-08-31 | Regents of the University of Minnesota | PRRS viruses, infectious clones, mutants thereof, and methods of use |
US7666585B2 (en) * | 2007-06-15 | 2010-02-23 | Protatek International, Inc. | Construction of chimera PRRSV, compositions and vaccine preparations |
PL2181189T3 (pl) * | 2007-06-25 | 2012-11-30 | South Dakota State Univ | Rekombinowany wirus zespołu rozrodczo-oddechowego świń północno-amerykańskiego typu 1 i sposoby jego stosowania |
CN108704127A (zh) * | 2008-08-25 | 2018-10-26 | 贝林格尔.英格海姆维特梅迪卡有限公司 | 抗高致病性猪生殖与呼吸综合征(hp prrs)的疫苗 |
TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
UA108902C2 (uk) | 2010-11-10 | 2015-06-25 | Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування | |
WO2012110490A1 (en) | 2011-02-17 | 2012-08-23 | Boehringer Ingelheim Vetmedica Gmbh | Commercial scale process for production of prrsv |
EP2959916B1 (en) | 2011-02-17 | 2018-08-08 | Boehringer Ingelheim Vetmedica GmbH | Novel european prrsv strain |
JP6101251B2 (ja) * | 2011-05-07 | 2017-03-22 | ラボラトリオ アヴィメキシコ エスエー ディーイー シーヴィーLaboratorio Avi−Mex, S.A. De C.V. | ウイルスベクターにおける抗prrs組換えワクチン |
US9669085B2 (en) | 2011-06-01 | 2017-06-06 | Merial Inc. | Needle-free administration of PRRSV vaccines |
WO2013017570A1 (en) | 2011-07-29 | 2013-02-07 | Boehringer Ingelheim Vetmedica Gmbh | Novel prrs virus inducing type i interferon in susceptible cells |
US9187731B2 (en) | 2011-07-29 | 2015-11-17 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus inducing type I interferon in susceptible cells |
MX2014013964A (es) | 2012-05-17 | 2015-03-04 | Zoetis Llc | Vacunacion eficaz contral el virus del sindrome reproductivo y respiratorio porcino (prrs) antes del destete. |
CN105073130A (zh) * | 2013-03-15 | 2015-11-18 | 勃林格殷格翰动物保健公司 | 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法 |
CA2990643C (en) * | 2015-06-23 | 2023-10-17 | Merial, Inc. | Prrsv minor protein-containing recombinant viral vectors and methods of making and use thereof |
MX2019006992A (es) | 2016-12-14 | 2019-08-29 | Zoetis Services Llc | Vacunacion eficaz contra cepas europeas del virus del sindrome reproductivo y respiratorio porcino (prrs) previo al destete. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9202724A (es) * | 1991-06-06 | 1992-12-31 | Stichting Centr Diergeneeskund | Composicion que comprende un vector recombinante del agente lelystad y vacuna que comprende la misma. |
KR100241221B1 (ko) * | 1991-08-26 | 2000-03-02 | 에드워드 콜린스 제임스 | 돼지 불임 및 호흡기계 중후백신 및 그의 진단법 |
US5695766A (en) * | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
ATE206455T1 (de) * | 1994-04-11 | 2001-10-15 | Akzo Nobel Nv | Europäische vakzinstämme des fortplanzungs- atmungs-syndromsvirus des schweins |
-
1995
- 1995-08-04 MX MX9700817A patent/MX9700817A/es active IP Right Grant
- 1995-08-04 DE DE69535061T patent/DE69535061T2/de not_active Revoked
- 1995-08-04 ES ES95928746T patent/ES2262142T3/es not_active Expired - Lifetime
- 1995-08-04 AT AT95928746T patent/ATE329616T1/de active
- 1995-08-04 CA CA2196555A patent/CA2196555C/en not_active Expired - Lifetime
- 1995-08-04 PT PT95928746T patent/PT783321E/pt unknown
- 1995-08-04 WO PCT/US1995/009927 patent/WO1996004010A1/en active IP Right Grant
- 1995-08-04 JP JP50679096A patent/JP3748887B2/ja not_active Expired - Lifetime
- 1995-08-04 EP EP06007265A patent/EP1704869A1/en not_active Withdrawn
- 1995-08-04 EP EP95928746A patent/EP0783321B1/en not_active Revoked
- 1995-08-04 DK DK95928746T patent/DK0783321T3/da active
-
1997
- 1997-02-13 US US08/799,464 patent/US5998601A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0783321A4 (en) | 1998-01-14 |
PT783321E (pt) | 2006-08-31 |
CA2196555A1 (en) | 1996-02-15 |
WO1996004010A1 (en) | 1996-02-15 |
JP3748887B2 (ja) | 2006-02-22 |
EP0783321A1 (en) | 1997-07-16 |
ES2262142T3 (es) | 2006-11-16 |
JPH10504191A (ja) | 1998-04-28 |
EP1704869A1 (en) | 2006-09-27 |
ATE329616T1 (de) | 2006-07-15 |
DE69535061D1 (de) | 2006-07-27 |
EP0783321B1 (en) | 2006-06-14 |
US5998601A (en) | 1999-12-07 |
DK0783321T3 (da) | 2006-10-02 |
DE69535061T2 (de) | 2007-01-25 |
CA2196555C (en) | 2012-07-03 |
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