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MX9405132A - Tetrahidro pirazolopiridinas biciclicas. - Google Patents

Tetrahidro pirazolopiridinas biciclicas.

Info

Publication number
MX9405132A
MX9405132A MX9405132A MX9405132A MX9405132A MX 9405132 A MX9405132 A MX 9405132A MX 9405132 A MX9405132 A MX 9405132A MX 9405132 A MX9405132 A MX 9405132A MX 9405132 A MX9405132 A MX 9405132A
Authority
MX
Mexico
Prior art keywords
pirazolopiridinas
biciclicas
tetrahidro
tnf
formula
Prior art date
Application number
MX9405132A
Other languages
English (en)
Inventor
Allen Jacob Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX9405132A publication Critical patent/MX9405132A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuesto de la fórmula I: donde R1, R2, R3 y X son como se definenanteriormente. Los compuestos de la fórmula I y sus sales aceptablesfarmacéuticamente son útiles en inhibir fosfodiesterasa (PDE) tipo IV y laproducción de factor de necrosis de tumores (TNF y en el tratamiento deasma, artritis, bronquitis, enfermedad obstructiva crónica de las víasrespiratorias, soriasis, rinitis alérgica, dermatitis y otras enfermedadesinflamatorias, SIDA, choque séptico y otras enfermedades que implican laproducción de TNF.
MX9405132A 1993-07-06 1994-07-05 Tetrahidro pirazolopiridinas biciclicas. MX9405132A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8829293A 1993-07-06 1993-07-06

Publications (1)

Publication Number Publication Date
MX9405132A true MX9405132A (es) 1995-01-31

Family

ID=22210524

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9405132A MX9405132A (es) 1993-07-06 1994-07-05 Tetrahidro pirazolopiridinas biciclicas.

Country Status (20)

Country Link
EP (1) EP0707585A1 (es)
JP (1) JP2944048B2 (es)
KR (1) KR100228949B1 (es)
CN (1) CN1048015C (es)
AU (1) AU695301B2 (es)
BR (1) BR9406946A (es)
CA (1) CA2166721C (es)
CZ (1) CZ3696A3 (es)
EG (1) EG20513A (es)
FI (1) FI943208A (es)
HU (1) HUT74170A (es)
IL (1) IL110175A (es)
MX (1) MX9405132A (es)
NO (1) NO305029B1 (es)
NZ (1) NZ266525A (es)
PL (1) PL312426A1 (es)
RU (1) RU2131876C1 (es)
TW (1) TW316904B (es)
WO (1) WO1995001980A1 (es)
ZA (1) ZA944844B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0787132A1 (en) * 1994-10-20 1997-08-06 Pfizer Inc. Bicyclic tetrahydro pyrazolopyridines and their use as medicaments
CA2223624C (en) * 1995-06-06 2001-02-20 Pfizer Inc. Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines
AP932A (en) * 1996-08-26 2001-02-02 Pfizer Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
US6262040B1 (en) * 1996-09-04 2001-07-17 Pfizer Inc Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF)
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
NZ511674A (en) 1998-12-23 2003-11-28 Du Pont Pharm Co Nitrogen containing heterobicycles as factor Xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
TR200909479T2 (tr) 1999-08-21 2012-02-21 Nycomed Gmbh Sinerjistik kombinasyon.
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
AU2001287654B2 (en) * 2000-08-10 2006-12-14 Pfizer Italia S.R.I. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
EP1379244A4 (en) 2001-04-18 2006-03-15 Bristol Myers Squibb Co 1,4,5,6-TETRAHYDROPYRAZOLO-3,4-C] -PYRIDINE-7-ONE AS FACTOR XA HEMMER
EP1379245A4 (en) 2001-04-18 2006-07-26 Bristol Myers Squibb Co 1, 4, 5, 6-TETRAHYDROPYRAZOLO- 3, 4-C-PYRIDINE-7-ONE AS FACTOR XA HEMMER
EP1396493A4 (en) * 2001-04-26 2005-08-03 Ajinomoto Kk HETEROCYCLIC COMPOUNDS
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
TWI325865B (en) 2003-02-27 2010-06-11 Palau Pharma Sa Pyrazolopyridine derivatives
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
CA2517487A1 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
DE102005031580A1 (de) * 2005-07-06 2007-01-11 Aicuris Gmbh & Co. Kg Substituierte Sulfolanylpyrazole und ihre Verwendung
PE20081889A1 (es) * 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
EP2998314B1 (en) 2007-06-04 2020-01-22 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
BR112016002789A2 (pt) 2013-08-09 2017-11-21 Ardelyx Inc compostos e métodos para inibir transporte de fosfato
CN110357888A (zh) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 杂环磷酸二酯酶抑制剂及其用途
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Also Published As

Publication number Publication date
IL110175A0 (en) 1994-10-07
TW316904B (es) 1997-10-01
HU9503934D0 (en) 1996-03-28
NZ266525A (en) 1997-10-24
BR9406946A (pt) 1996-08-06
FI943208A0 (fi) 1994-07-05
WO1995001980A1 (en) 1995-01-19
JP2944048B2 (ja) 1999-08-30
RU2131876C1 (ru) 1999-06-20
NO960056L (no) 1996-01-05
AU695301B2 (en) 1998-08-13
CZ3696A3 (en) 1997-06-11
IL110175A (en) 2000-01-31
CA2166721C (en) 1999-07-27
NO960056D0 (no) 1996-01-05
EG20513A (en) 1999-06-30
CA2166721A1 (en) 1995-01-19
ZA944844B (en) 1996-01-05
KR960703852A (ko) 1996-08-31
HUT74170A (en) 1996-11-28
PL312426A1 (en) 1996-04-29
CN1129940A (zh) 1996-08-28
KR100228949B1 (ko) 1999-11-01
CN1048015C (zh) 2000-01-05
FI943208A (fi) 1995-01-07
NO305029B1 (no) 1999-03-22
JPH08507084A (ja) 1996-07-30
EP0707585A1 (en) 1996-04-24
AU6805794A (en) 1995-02-06

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