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MX9307777A - 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. - Google Patents

7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.

Info

Publication number
MX9307777A
MX9307777A MX9307777A MX9307777A MX9307777A MX 9307777 A MX9307777 A MX 9307777A MX 9307777 A MX9307777 A MX 9307777A MX 9307777 A MX9307777 A MX 9307777A MX 9307777 A MX9307777 A MX 9307777A
Authority
MX
Mexico
Prior art keywords
cancer
taxoles
halo
methane
contain
Prior art date
Application number
MX9307777A
Other languages
English (en)
Inventor
Eldon G Nidy
Jackson B Hester Jr
Roy A Johnson
Robert C Kelly
Harvey I Skulnick
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27486333&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9307777(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX9307777A publication Critical patent/MX9307777A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invención provee análogos de 7-desoxi-taxol de la fórmula I: Los compuestos de la fórmula I (incluyendo II y III) son útiles para los mismos tipos de cáncer en los cuales los taxoles han demostrado actividad, incluyendo en humanos el cáncer ovárico, cáncer de la mama y melanoma maligno, como también el cáncer pulmonar, cáncer gástrico, cáncer de colon, cáncer de cabeza y cuello y la leucemia.
MX9307777A 1992-12-15 1993-12-09 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. MX9307777A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99057992A 1992-12-15 1992-12-15
US1382693A 1993-02-02 1993-02-02
US7633793A 1993-06-11 1993-06-11
US12297493A 1993-09-17 1993-09-17

Publications (1)

Publication Number Publication Date
MX9307777A true MX9307777A (es) 1994-07-29

Family

ID=27486333

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9307777A MX9307777A (es) 1992-12-15 1993-12-09 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.

Country Status (26)

Country Link
US (1) US6911549B1 (es)
EP (1) EP0674630B1 (es)
JP (1) JP3441458B2 (es)
KR (1) KR100317015B1 (es)
CN (2) CN1062561C (es)
AT (1) ATE226576T1 (es)
AU (1) AU687027B2 (es)
CA (1) CA2149021A1 (es)
CZ (1) CZ291177B6 (es)
DE (1) DE69332438T2 (es)
DK (1) DK0674630T3 (es)
ES (1) ES2187519T3 (es)
FI (1) FI111633B (es)
HU (1) HUT74447A (es)
IL (1) IL107950A (es)
LV (1) LV13023B (es)
MX (1) MX9307777A (es)
MY (1) MY116473A (es)
NO (1) NO313801B1 (es)
NZ (1) NZ259196A (es)
PL (1) PL185042B1 (es)
PT (1) PT674630E (es)
RU (1) RU2125996C1 (es)
SK (1) SK281897B6 (es)
TW (1) TW389758B (es)
WO (1) WO1994013655A1 (es)

Families Citing this family (45)

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US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5814658A (en) 1992-12-09 1998-09-29 Rhone-Poulenc Rorer S.A. Taxoids, their preparation and pharmaceutical compositions containing them
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
FR2712288B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
GB9409131D0 (en) * 1994-05-09 1994-06-29 Erba Carlo Spa Unsaturated taxane compounds
FR2726272B1 (fr) * 1994-10-26 1996-12-06 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
WO1996014309A1 (en) * 1994-11-04 1996-05-17 Pharmacia & Upjohn S.P.A Taxane derivatives
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
FR2732342B1 (fr) * 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
AU4768797A (en) * 1996-10-24 1998-05-15 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
HUP0200995A3 (en) * 2000-02-02 2005-02-28 Univ Florida State Res Found Taxane formulations having improved solubility
PL350028A1 (en) 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
EP1165552A1 (en) 2000-02-02 2002-01-02 Florida State University Research Foundation, Inc. C7 carbonate substituted taxanes as antitumor agents
EP1318794A2 (en) 2000-09-22 2003-06-18 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
CA2354478A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes
SG125888A1 (en) * 2001-08-01 2006-10-30 Univ Florida State Res Found C10 carbonate substituted taxanes
CA2501805C (en) * 2002-10-09 2012-05-22 Phytogen Life Sciences, Inc. Novel taxanes and methods related to use and preparation thereof
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
HN2005000054A (es) 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
AU2012202903B2 (en) * 2005-02-18 2014-12-11 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
CN103143069B (zh) * 2005-02-18 2016-05-04 阿布拉西斯生物科学公司 用于整合入医疗装置的疏水性改善的药物
EP2471555A3 (en) 2005-07-15 2012-10-17 Angiochem Inc. Use of aprotinin polypeptides as carriers in pharmaceutical conjugates
PL3851447T3 (pl) 2006-10-12 2024-03-04 Bellus Health Inc. Sposoby, związki, kompozycje i nośniki dostarczające kwas 3-amino-1-propanosulfonowy
EP2164866B1 (en) 2007-05-29 2014-05-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
AU2008288651A1 (en) * 2007-08-22 2009-02-26 6570763 Canada Inc. Process for converting 9-dihydro-13-acetylbaccatin III into docetaxel or paclitaxel
EP2080764B1 (en) 2008-01-18 2012-08-22 INDENA S.p.A. Solid forms of ortataxel
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CN101648973B (zh) * 2009-09-03 2012-05-30 漆又毛 水溶性紫杉烷及制备方法
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CN107921143B (zh) 2015-06-15 2021-11-19 安吉奥开米公司 用于治疗软脑膜癌病的方法
CN111138386A (zh) * 2019-12-30 2020-05-12 重庆市碚圣医药科技股份有限公司 一种多西他赛的半合成方法
CN111763179A (zh) * 2020-07-08 2020-10-13 云南汉德生物技术有限公司 一种紫杉醇侧链的合成方法
CN115260130A (zh) * 2022-07-07 2022-11-01 上海卓鼎生物技术有限公司 一种10-脱乙酰基紫杉醇的制备方法

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AU619125B2 (en) 1989-06-09 1992-01-16 Dow Chemical Company, The Process for preparing a polymer having perfluorocyclobutane rings and polymers containing perfluorocyclobutane rings
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FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
DK0674630T3 (da) 2003-02-24
CN1095377A (zh) 1994-11-23
MY116473A (en) 2004-02-28
HU9501733D0 (en) 1995-08-28
PL309392A1 (en) 1995-10-02
ES2187519T3 (es) 2003-06-16
SK78895A3 (en) 1995-12-06
NO952351L (no) 1995-08-14
CN1062561C (zh) 2001-02-28
CA2149021A1 (en) 1994-06-23
LV13023B (en) 2003-12-20
PL185042B1 (pl) 2003-02-28
EP0674630B1 (en) 2002-10-23
WO1994013655A1 (en) 1994-06-23
FI952920A0 (fi) 1995-06-14
FI111633B (fi) 2003-08-29
IL107950A (en) 2001-04-30
CZ291177B6 (cs) 2003-01-15
NZ259196A (en) 1998-08-26
AU687027B2 (en) 1998-02-19
IL107950A0 (en) 1994-04-12
TW389758B (en) 2000-05-11
PT674630E (pt) 2003-03-31
HUT74447A (en) 1996-12-30
EP0674630A1 (en) 1995-10-04
US6911549B1 (en) 2005-06-28
JP3441458B2 (ja) 2003-09-02
JPH08506568A (ja) 1996-07-16
CN1261072A (zh) 2000-07-26
KR100317015B1 (ko) 2002-06-22
SK281897B6 (sk) 2001-09-11
KR950704288A (ko) 1995-11-17
AU5741194A (en) 1994-07-04
RU95114377A (ru) 1997-06-10
ATE226576T1 (de) 2002-11-15
FI952920A (fi) 1995-06-14
DE69332438D1 (de) 2002-11-28
DE69332438T2 (de) 2003-06-18
NO313801B1 (no) 2002-12-02
RU2125996C1 (ru) 1999-02-10
NO952351D0 (no) 1995-06-14
CZ143795A3 (en) 1995-11-15

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