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MX9306234A - Oxindoles y azaoxoindoles 1-substituidos y composiciones farmaceuticas que los contienen. - Google Patents

Oxindoles y azaoxoindoles 1-substituidos y composiciones farmaceuticas que los contienen.

Info

Publication number
MX9306234A
MX9306234A MX9306234A MX9306234A MX9306234A MX 9306234 A MX9306234 A MX 9306234A MX 9306234 A MX9306234 A MX 9306234A MX 9306234 A MX9306234 A MX 9306234A MX 9306234 A MX9306234 A MX 9306234A
Authority
MX
Mexico
Prior art keywords
oxydoles
azaoxoindoles
substituted
contain
pharmaceutical compositions
Prior art date
Application number
MX9306234A
Other languages
English (en)
Inventor
Shristopher Allan Teleha
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of MX9306234A publication Critical patent/MX9306234A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Se describen los compuestos de fórmula I que han mostrado que mejoran la liberación del neutrotransmisor acetilcolina, y de este modo pueden ser útiles como intermediarios químicos y como agentes farmacológicos en el tratamiento de enfermedades del hombre, tales como en la enfermedad de Alzheimer y otras condiciones que involucran el aprendizaje y la cognición o el conocimiento, donde se encuentran niveles subnormales de agente neuroquímico.
MX9306234A 1992-10-07 1993-10-06 Oxindoles y azaoxoindoles 1-substituidos y composiciones farmaceuticas que los contienen. MX9306234A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/957,152 US5296478A (en) 1992-10-07 1992-10-07 1-substituted oxindoles as cognition enhancers

Publications (1)

Publication Number Publication Date
MX9306234A true MX9306234A (es) 1994-05-31

Family

ID=25499153

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9306234A MX9306234A (es) 1992-10-07 1993-10-06 Oxindoles y azaoxoindoles 1-substituidos y composiciones farmaceuticas que los contienen.

Country Status (7)

Country Link
US (2) US5296478A (es)
AU (1) AU5292893A (es)
IL (1) IL107177A0 (es)
MX (1) MX9306234A (es)
TW (1) TW268943B (es)
WO (1) WO1994007891A1 (es)
ZA (1) ZA937453B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744476A (en) * 1994-06-27 1998-04-28 Interneuron Pharmaceuticals, Inc. Dopamine D1 agonists for the treatment of dementia
HUP9801155A3 (en) * 1995-02-15 1999-03-01 Richter Gedeon Vegyeszet Use of vinpocetine derivatives for inhibiting production or secretion of amyloid beta protein
HRP980429A2 (en) 1997-08-14 1999-06-30 Jianguo Yin Crystalline 10,10-bis ((2-fluoro-4-pyridinyl)methyl)-9(10h)-anthracenone and an improved process for preparing the same
US20050101929A1 (en) * 2002-01-17 2005-05-12 Andrew Waksmundzki Absorbent core with three-dimensional sub-layer
AR053710A1 (es) 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY158766A (en) * 2005-04-11 2016-11-15 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR053713A1 (es) * 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc Compuestos heterociclicos y sus usos como agentes terapeuticos
US20080176793A1 (en) * 2006-09-18 2008-07-24 The Regents Of The University Of California Upregulating activity or expression of bdnf to mitigate cognitive impairment in asymptomatic huntington's subjects
WO2008046046A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
CN101631546A (zh) * 2006-10-12 2010-01-20 泽农医药公司 螺-吲哚酮化合物作为治疗剂的用途
US20110294842A9 (en) * 2006-10-12 2011-12-01 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
US8101647B2 (en) * 2008-10-17 2012-01-24 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
MX2011004055A (es) * 2008-10-17 2011-06-24 Xenon Pharmaceuticals Inc Compuestos de espiro-oxindol y su uso como agentes terapeuticos.
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
CA2777543A1 (en) * 2009-10-14 2011-04-21 Xenon Pharmaceuticals Inc. Synthetic methods for spiro-oxindole compounds
AU2011220396B2 (en) 2010-02-26 2016-10-13 Xenon Pharmaceuticals Inc. Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
US9682033B2 (en) 2015-02-05 2017-06-20 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
CN106565683B (zh) * 2016-09-30 2019-03-12 江汉大学 一种合成3-羟基氧化吲哚衍生物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3314954A (en) * 1964-12-09 1967-04-18 Parke Davis & Co 1-(diloweralkylamino)-3-(aminoloweralkyl)-3-phenyloxindoles
US3595866A (en) * 1970-01-19 1971-07-27 Parke Davis & Co 1-amino-3-aminoalkyl-3-phenyloxindole-compounds
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
AU3776589A (en) * 1988-06-14 1990-01-12 Schering Corporation Heterobicyclic compounds having antiinflammatory activity
JP2739188B2 (ja) * 1989-07-25 1998-04-08 大鵬薬品工業株式会社 オキシインドール誘導体
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US5278162A (en) * 1992-09-18 1994-01-11 The Du Pont Merck Pharmaceutical Company 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man

Also Published As

Publication number Publication date
US5296478A (en) 1994-03-22
ZA937453B (en) 1995-04-07
TW268943B (es) 1996-01-21
AU5292893A (en) 1994-04-26
WO1994007891A1 (en) 1994-04-14
US5428035A (en) 1995-06-27
IL107177A0 (en) 1994-01-25

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