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MX362858B - Proceso para la preparacion de pemetrexed y sal de lisina del mismo. - Google Patents

Proceso para la preparacion de pemetrexed y sal de lisina del mismo.

Info

Publication number
MX362858B
MX362858B MX2015001712A MX2015001712A MX362858B MX 362858 B MX362858 B MX 362858B MX 2015001712 A MX2015001712 A MX 2015001712A MX 2015001712 A MX2015001712 A MX 2015001712A MX 362858 B MX362858 B MX 362858B
Authority
MX
Mexico
Prior art keywords
pemetrexed
preparation
salt
crystalline form
lysin salt
Prior art date
Application number
MX2015001712A
Other languages
English (en)
Other versions
MX2015001712A (es
Inventor
Bonaccorsi Fabrizio
Calvani Federico
Pasqui Franco
Original Assignee
Berlin Chemie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlin Chemie Ag filed Critical Berlin Chemie Ag
Publication of MX2015001712A publication Critical patent/MX2015001712A/es
Publication of MX362858B publication Critical patent/MX362858B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un proceso para la síntesis de pemetrexed y sales del mismo, en particular con una sal de lisina del mismo, con la sal como tal y con las composiciones farmacéuticas que comprenden la misma. Además, la presente descripción también se relaciona con una forma cristalina de la síntesis del dietiléter de pemetrexed intermediario y una forma cristalina de la sal de lisina de pemetrexed.
MX2015001712A 2012-08-08 2013-08-08 Proceso para la preparacion de pemetrexed y sal de lisina del mismo. MX362858B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000398A ITRM20120398A1 (it) 2012-08-08 2012-08-08 Procedimento di sintesi pemetrexed e suo sale di lisina.
PCT/IB2013/056497 WO2014024164A1 (en) 2012-08-08 2013-08-08 Process for the preparation of pemetrexed and lysin salt thereof

Publications (2)

Publication Number Publication Date
MX2015001712A MX2015001712A (es) 2015-08-14
MX362858B true MX362858B (es) 2019-02-20

Family

ID=47018368

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015001712A MX362858B (es) 2012-08-08 2013-08-08 Proceso para la preparacion de pemetrexed y sal de lisina del mismo.

Country Status (24)

Country Link
EP (1) EP2882753B1 (es)
KR (1) KR102288417B1 (es)
CN (1) CN104736540B (es)
AU (1) AU2013301156B2 (es)
BR (1) BR112015002429A8 (es)
CY (1) CY1118514T1 (es)
DK (1) DK2882753T3 (es)
ES (1) ES2607890T3 (es)
HK (1) HK1209426A1 (es)
HR (1) HRP20170011T1 (es)
HU (1) HUE032304T2 (es)
IN (1) IN2015DN00833A (es)
IT (1) ITRM20120398A1 (es)
LT (1) LT2882753T (es)
MX (1) MX362858B (es)
PL (1) PL2882753T3 (es)
PT (1) PT2882753T (es)
RS (1) RS55515B1 (es)
RU (1) RU2609006C2 (es)
SI (1) SI2882753T1 (es)
SM (1) SMT201600474B (es)
TW (1) TWI609017B (es)
WO (1) WO2014024164A1 (es)
ZA (1) ZA201501549B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107641124A (zh) * 2016-07-22 2018-01-30 上海创诺制药有限公司 一种培美曲塞二酸新晶型及其制备方法
CN109836425B (zh) * 2017-11-24 2023-01-24 江苏创诺制药有限公司 一种合成培美酸的制备工艺
CN110128427A (zh) * 2018-02-09 2019-08-16 鲁南制药集团股份有限公司 培美曲塞缬氨酸盐
CN110128428A (zh) * 2018-02-09 2019-08-16 鲁南制药集团股份有限公司 培美曲塞丙氨酸盐
CN110128426B (zh) * 2018-02-09 2021-12-14 鲁南制药集团股份有限公司 培美曲塞谷氨酸盐
CN111333658A (zh) * 2020-05-06 2020-06-26 贵州联科中贝制药科技有限公司 一种培美曲塞二钠水合物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0440795B1 (en) 1988-10-31 1994-10-19 MITSUI TOATSU CHEMICALS, Inc. Process for preparing organic group-substituted sodium aluminum hydride
KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
IL96531A (en) 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
RU2127274C1 (ru) * 1992-09-25 1999-03-10 Эли Лилли Энд Компани СПОСОБ ПОЛУЧЕНИЯ 5-ЗАМЕЩЕННЫХ ПИРРОЛО (2,3-α)ПИРИМИДИНОВ
US5416211A (en) 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
DE19725647A1 (de) 1997-06-18 1998-12-24 Basf Ag Cyclopenta[I]phenanthren-Metallkomplex-Katalysatorsysteme
ZA987550B (en) 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
ES2206403T3 (es) 2000-02-25 2004-05-16 Eli Lilly And Company Nueva forma cristalina de acido n-(4-(2-(2-amino-4,7dihidro-4.oxo-3h-pirrolo(2,3-d)pirimidin-5-il)etil(benzoil)-l-glutamico y procedimiento de preparacion.
JP2008543975A (ja) * 2006-08-14 2008-12-04 シコール インコーポレイティド 高度に純粋なペメトレキセド二酸およびその調製方法
TWI374886B (en) * 2006-08-14 2012-10-21 Sicor Inc Processes for preparing intermediates of pemetrexed
CN101591247B (zh) * 2008-05-30 2012-09-05 上海希迪制药有限公司 合成4-(4-甲酯基苯基)丁醛的方法
IT1401677B1 (it) * 2010-07-22 2013-08-02 Chemi Spa Nuovo processo per la sintesi di pemetrexed sale disodico
JP2013540104A (ja) 2010-07-28 2013-10-31 イーグル・ファーマシューティカルズ・インコーポレーテッド 延長された保存安定性を有するペメトレキセドを含有する医薬組成物
WO2012056285A1 (en) * 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed

Also Published As

Publication number Publication date
CN104736540A (zh) 2015-06-24
CY1118514T1 (el) 2017-07-12
KR20150045458A (ko) 2015-04-28
PL2882753T3 (pl) 2017-04-28
ITRM20120398A1 (it) 2014-02-09
RS55515B1 (sr) 2017-05-31
SI2882753T1 (sl) 2017-02-28
LT2882753T (lt) 2016-12-12
IN2015DN00833A (es) 2015-06-12
ZA201501549B (en) 2016-01-27
WO2014024164A1 (en) 2014-02-13
MX2015001712A (es) 2015-08-14
BR112015002429A2 (pt) 2017-07-04
RU2609006C2 (ru) 2017-01-30
PT2882753T (pt) 2016-12-27
RU2015108042A (ru) 2016-09-27
HK1209426A1 (zh) 2016-04-01
EP2882753A1 (en) 2015-06-17
HRP20170011T1 (hr) 2017-03-10
EP2882753B1 (en) 2016-10-05
AU2013301156A1 (en) 2015-02-05
TW201412741A (zh) 2014-04-01
DK2882753T3 (en) 2017-01-16
HUE032304T2 (en) 2017-09-28
CN104736540B (zh) 2017-08-25
TWI609017B (zh) 2017-12-21
AU2013301156B2 (en) 2017-08-31
SMT201600474B (it) 2017-03-08
ES2607890T3 (es) 2017-04-04
BR112015002429A8 (pt) 2019-07-30
KR102288417B1 (ko) 2021-08-11

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