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MX362271B - Nueva forma cristalina de ciclosporina a, metodos de preparacion y metodos para su uso. - Google Patents

Nueva forma cristalina de ciclosporina a, metodos de preparacion y metodos para su uso.

Info

Publication number
MX362271B
MX362271B MX2013013855A MX2013013855A MX362271B MX 362271 B MX362271 B MX 362271B MX 2013013855 A MX2013013855 A MX 2013013855A MX 2013013855 A MX2013013855 A MX 2013013855A MX 362271 B MX362271 B MX 362271B
Authority
MX
Mexico
Prior art keywords
methods
cyclosporine
preparation
crystalline form
crystalline forms
Prior art date
Application number
MX2013013855A
Other languages
English (en)
Other versions
MX2013013855A (es
Inventor
Karami Kiomars
s graham Richard
V Gore Anuradha
W Smith Scott
Wu Ke
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46178866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX362271(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of MX2013013855A publication Critical patent/MX2013013855A/es
Publication of MX362271B publication Critical patent/MX362271B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se relaciona generalmente con formas cristalinas de ciclosporina A y particularmente con una forma nueva identificada de ciclosporina A. la invención se relaciona con métodos para su preparación y métodos para tratar algunos trastornos aculares.
MX2013013855A 2011-05-27 2012-05-25 Nueva forma cristalina de ciclosporina a, metodos de preparacion y metodos para su uso. MX362271B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161490887P 2011-05-27 2011-05-27
PCT/US2012/039611 WO2012166610A1 (en) 2011-05-27 2012-05-25 A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof

Publications (2)

Publication Number Publication Date
MX2013013855A MX2013013855A (es) 2014-02-17
MX362271B true MX362271B (es) 2019-01-10

Family

ID=46178866

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013855A MX362271B (es) 2011-05-27 2012-05-25 Nueva forma cristalina de ciclosporina a, metodos de preparacion y metodos para su uso.

Country Status (19)

Country Link
US (4) US8772245B2 (es)
EP (2) EP3521302A1 (es)
JP (1) JP6163482B2 (es)
KR (1) KR102079402B1 (es)
CN (1) CN103649108B (es)
AR (1) AR086586A1 (es)
AU (4) AU2012262513B2 (es)
BR (1) BR112013030554B1 (es)
CA (1) CA2836946C (es)
CL (1) CL2013003400A1 (es)
IL (2) IL229475A0 (es)
MX (1) MX362271B (es)
MY (1) MY180581A (es)
RU (1) RU2602062C2 (es)
SG (1) SG10201607344UA (es)
TW (1) TWI554522B (es)
UA (1) UA113627C2 (es)
WO (1) WO2012166610A1 (es)
ZA (1) ZA201308665B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104039813B (zh) 2011-11-15 2017-08-29 阿勒根公司 环孢菌素a形式2及其制备方法
AU2012339701B8 (en) * 2011-11-15 2017-11-16 Allergan, Inc. Autoclavable suspensions of cyclosporin A Form 2
BR112014011744A2 (pt) * 2011-11-15 2017-05-02 Allergan Inc formulação de ação sustentável da forma 2 de ciclosporina
JP6363506B2 (ja) * 2011-11-15 2018-07-25 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ２型の懸濁剤
EP3263587A1 (en) 2012-06-01 2018-01-03 Allergan, Inc. Cyclosporin a analogs
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
US10524661B2 (en) * 2013-06-12 2020-01-07 Proactive Live, Inc. Sleep monitoring and stimulation
KR20170030093A (ko) 2014-07-18 2017-03-16 알레간 인코포레이티드 결막하 및 눈주위 주사를 위한 사이클로스포린 a의 현탁액 조성물
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
US10443292B2 (en) * 2016-04-25 2019-10-15 Magna Closures, Inc. Non-contact obstacle detection system for motor vehicles
ES2982308T3 (es) * 2017-05-17 2024-10-15 Yuyu Pharma Inc Péptido novedoso y composición farmacéutica para tratar una enfermedad ocular que comprende el mismo como un ingrediente farmacéutico activo
US11613558B2 (en) 2018-11-14 2023-03-28 Yuyu Pharma, Inc. Peptides and pharmaceutical compositions for treating eye diseases
WO2024085235A1 (ja) * 2022-10-20 2024-04-25 中外製薬株式会社 環状ペプチドの結晶の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US5474979A (en) * 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
RU2009144186A (ru) * 2007-05-04 2011-06-10 Аллерган, Инк. (Us) Применение циклоспоринов при лечении пациентов с интраокулярными линзами
US20090286718A1 (en) * 2008-01-04 2009-11-19 Sirion Therapeutics, Inc. Stable Aqueous Cyclosporin Compositions

Also Published As

Publication number Publication date
US20210269484A1 (en) 2021-09-02
IL290158A (en) 2022-03-01
US8772245B2 (en) 2014-07-08
CN103649108A (zh) 2014-03-19
BR112013030554B1 (pt) 2020-12-15
KR20140047054A (ko) 2014-04-21
CA2836946A1 (en) 2012-12-06
JP2014515372A (ja) 2014-06-30
UA113627C2 (xx) 2017-02-27
ZA201308665B (en) 2014-07-30
RU2013155033A (ru) 2015-07-20
CN103649108B (zh) 2017-03-29
MX2013013855A (es) 2014-02-17
BR112013030554A2 (pt) 2016-09-06
NZ618213A (en) 2016-05-27
AU2019204192B2 (en) 2021-02-04
US20130023482A1 (en) 2013-01-24
AR086586A1 (es) 2014-01-08
US20140315827A1 (en) 2014-10-23
EP3521302A1 (en) 2019-08-07
NZ719272A (en) 2017-10-27
AU2012262513A1 (en) 2013-12-12
AU2016203990A1 (en) 2016-06-30
CL2013003400A1 (es) 2014-08-18
RU2602062C2 (ru) 2016-11-10
CA2836946C (en) 2017-08-01
KR102079402B1 (ko) 2020-02-19
US20160083432A1 (en) 2016-03-24
EP2714720A1 (en) 2014-04-09
WO2012166610A1 (en) 2012-12-06
AU2012262513B2 (en) 2016-03-17
AU2019204192A1 (en) 2019-07-04
TW201311730A (zh) 2013-03-16
SG10201607344UA (en) 2016-10-28
AU2017265008A1 (en) 2017-12-07
MY180581A (en) 2020-12-02
IL229475A0 (en) 2014-01-30
US9206228B2 (en) 2015-12-08
TWI554522B (zh) 2016-10-21
EP2714720B1 (en) 2018-12-26
JP6163482B2 (ja) 2017-07-12

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