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MX361916B - Inhibidores de mtor cinasa para indicadores de oncología y enfermedades asociadas con la trayectoria mtor/pi3k/akt. - Google Patents

Inhibidores de mtor cinasa para indicadores de oncología y enfermedades asociadas con la trayectoria mtor/pi3k/akt.

Info

Publication number
MX361916B
MX361916B MX2014000653A MX2014000653A MX361916B MX 361916 B MX361916 B MX 361916B MX 2014000653 A MX2014000653 A MX 2014000653A MX 2014000653 A MX2014000653 A MX 2014000653A MX 361916 B MX361916 B MX 361916B
Authority
MX
Mexico
Prior art keywords
mtor
kinase inhibitors
diseases associated
akt pathway
oncology indications
Prior art date
Application number
MX2014000653A
Other languages
English (en)
Inventor
Elsner Jan
L Harris Roy
Lee Branden
Mortensen Deborah
Packard Garrick
Papa Patrick
Perrin-Ninkovic Sophie
Riggs Jennifer
Sankar Sabita
Sapienza John
Shevlin Graziella
Tehrani Lida
Xu Weiming
Zhao Jingjing
Parnes Jason
Madakamutil Loui
Fultz Kimberly
K Narla Rama
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41490345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX361916(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of MX361916B publication Critical patent/MX361916B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)

Abstract

En la presente se proporcionan Compuestos Heteroarilo que tienen la siguiente estructura: R2 N (I) o (II) donde R1-R4 son como se definen en la presente, composiciones que comprenden una cantidad efectiva de un Compuesto Heteroarilo y métodos para tratar o prevenir cáncer, padecimientos inflamatorios, padecimientos inmunológicos, enfermedades neurodegenerativas, diabetes, obesidad, trastornos neurológicos, enfermedades relacionadas con la edad, o padecimientos cardiovasculares, que comprenden administrar una cantidad efectiva de un Compuesto Heteroarilo a un paciente que lo necesita.
MX2014000653A 2008-10-27 2009-10-27 Inhibidores de mtor cinasa para indicadores de oncología y enfermedades asociadas con la trayectoria mtor/pi3k/akt. MX361916B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10862708P 2008-10-27 2008-10-27
PCT/US2009/062143 WO2010062571A1 (en) 2008-10-27 2009-10-27 Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway

Publications (1)

Publication Number Publication Date
MX361916B true MX361916B (es) 2018-12-19

Family

ID=41490345

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2011004401A MX2011004401A (es) 2008-10-27 2009-10-27 Inhibidores de mtor cinasa para indicadores de oncologia y enfermedades asociadas con la trayectoria mtor/pi3k/akt.
MX2014000653A MX361916B (es) 2008-10-27 2009-10-27 Inhibidores de mtor cinasa para indicadores de oncología y enfermedades asociadas con la trayectoria mtor/pi3k/akt.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2011004401A MX2011004401A (es) 2008-10-27 2009-10-27 Inhibidores de mtor cinasa para indicadores de oncologia y enfermedades asociadas con la trayectoria mtor/pi3k/akt.

Country Status (35)

Country Link
US (10) US8110578B2 (es)
EP (5) EP3660020B1 (es)
JP (3) JP5689420B2 (es)
KR (2) KR101815604B1 (es)
CN (3) CN102245611B (es)
AR (2) AR073995A1 (es)
AU (1) AU2009320137C1 (es)
BR (1) BRPI0920254A2 (es)
CA (1) CA2740975C (es)
CO (1) CO6501147A2 (es)
CR (1) CR20110223A (es)
CY (2) CY1117272T1 (es)
DK (2) DK2740732T3 (es)
EC (1) ECSP11011084A (es)
ES (4) ES2562803T3 (es)
HK (3) HK1154858A1 (es)
HR (2) HRP20160084T1 (es)
HU (1) HUE026834T2 (es)
IL (1) IL212440A (es)
LT (1) LT2740732T (es)
MX (2) MX2011004401A (es)
MY (1) MY159235A (es)
NI (1) NI201100080A (es)
NZ (4) NZ619458A (es)
PE (3) PE20141197A1 (es)
PL (2) PL2740732T3 (es)
PT (1) PT2740732T (es)
RU (2) RU2692796C2 (es)
SG (3) SG10201402267VA (es)
SI (2) SI2740733T1 (es)
SM (1) SMT201600089B (es)
TW (3) TWI605047B (es)
UA (1) UA108601C2 (es)
WO (1) WO2010062571A1 (es)
ZA (1) ZA201102813B (es)

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