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MX365647B - El uso de compuestos antisentido dirigidos al factor de crecimiento del tejido conectivo (ctgf) para tratar queloides o cicatrices hipertroficas. - Google Patents

El uso de compuestos antisentido dirigidos al factor de crecimiento del tejido conectivo (ctgf) para tratar queloides o cicatrices hipertroficas.

Info

Publication number
MX365647B
MX365647B MX2013008963A MX2013008963A MX365647B MX 365647 B MX365647 B MX 365647B MX 2013008963 A MX2013008963 A MX 2013008963A MX 2013008963 A MX2013008963 A MX 2013008963A MX 365647 B MX365647 B MX 365647B
Authority
MX
Mexico
Prior art keywords
ctgf
growth factor
hypertrophic scars
connective tissue
antisense compounds
Prior art date
Application number
MX2013008963A
Other languages
English (en)
Other versions
MX2013008963A (es
Inventor
Nicholas M Dean
Lincoln Krochmal
Gregory Hardee
J Gordon Foulkes
Niall O'donnell
Leroy Young
Mark Jewell
Original Assignee
Excaliard Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Excaliard Pharmaceuticals Inc filed Critical Excaliard Pharmaceuticals Inc
Publication of MX2013008963A publication Critical patent/MX2013008963A/es
Publication of MX365647B publication Critical patent/MX365647B/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2320/00—Applications; Uses
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  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
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  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a una composición que comprende un olignucleótido antisentido modificado que consiste de 12-30 nucleósidos ligados, al menos una porción de secuencia de 12 nucleobases de la cual es complementaria a los nucleótidos presentes dentro de una región seleccionada de los nucleótidos 1388-1423, 1394-1423 y 1399-1423 de la SEQ ID NO. 9, o una sal o éster del mismo, para usarse en el tratamiento de un queloide, o prevención de la formación, reformación, o crecimiento de un queloide después de una lesión en la piel, en un sujeto en necesidad del mismo, en donde la composición está adaptada para ser administrable al sujeto por medio de una o más inyecciones lineales en el sitio del queloide o de la lesión en la piel, en una cantidad efectiva para tratar, o par aprevenir la formación reformación, o crecimiento del queloide, en donde la cantidad efectiva es de 01. A 50 mg del olignucleótido modificado por inyección por centímetro lineal del queloide o de la lesión de la piel.
MX2013008963A 2011-02-02 2012-02-02 El uso de compuestos antisentido dirigidos al factor de crecimiento del tejido conectivo (ctgf) para tratar queloides o cicatrices hipertroficas. MX365647B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161438879P 2011-02-02 2011-02-02
US201161488666P 2011-05-20 2011-05-20
US201161527821P 2011-08-26 2011-08-26
PCT/US2012/023620 WO2012106508A1 (en) 2011-02-02 2012-02-02 Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (ctgf)

Publications (2)

Publication Number Publication Date
MX2013008963A MX2013008963A (es) 2014-01-08
MX365647B true MX365647B (es) 2019-06-10

Family

ID=46603079

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008963A MX365647B (es) 2011-02-02 2012-02-02 El uso de compuestos antisentido dirigidos al factor de crecimiento del tejido conectivo (ctgf) para tratar queloides o cicatrices hipertroficas.

Country Status (19)

Country Link
US (3) US9173894B2 (es)
EP (1) EP2670411B1 (es)
JP (3) JP6177692B2 (es)
KR (1) KR101697396B1 (es)
CN (1) CN103635197A (es)
AU (4) AU2012212110A1 (es)
BR (1) BR112013019803A2 (es)
CA (1) CA2825059A1 (es)
DK (1) DK2670411T3 (es)
ES (1) ES2729956T3 (es)
HU (1) HUE044178T2 (es)
IL (1) IL227714B (es)
MX (1) MX365647B (es)
PL (1) PL2670411T3 (es)
PT (1) PT2670411T (es)
RU (1) RU2608655C2 (es)
SI (1) SI2670411T1 (es)
TW (1) TWI593416B (es)
WO (1) WO2012106508A1 (es)

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MX365647B (es) * 2011-02-02 2019-06-10 Excaliard Pharmaceuticals Inc El uso de compuestos antisentido dirigidos al factor de crecimiento del tejido conectivo (ctgf) para tratar queloides o cicatrices hipertroficas.
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CN105960265A (zh) * 2013-12-04 2016-09-21 阿克赛医药公司 利用经化学修饰的寡核苷酸处理伤口愈合的方法
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CN108251420B (zh) * 2016-12-28 2024-08-02 苏州瑞博生物技术股份有限公司 抑制人和动物中CTGF基因表达的siRNA、包含其的组合物及其应用
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JP2022532078A (ja) * 2019-05-08 2022-07-13 アストラゼネカ アクチボラグ 皮膚及び創傷のための組成物並びにその使用の方法
KR102100163B1 (ko) 2019-09-24 2020-04-13 테고사이언스 (주) 켈로이드 또는 비후성 반흔 예방 또는 치료용 조성물
CN110840894B (zh) * 2019-12-19 2020-06-02 温州医科大学附属第一医院 一种复合抗疤痕硅酮喷雾剂及其制备方法
CN111208223B (zh) * 2020-01-13 2023-01-17 浙江大学 心脏死亡后捐献受体术前预警移植肾延迟复功的代谢物
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CN114807127A (zh) * 2021-01-19 2022-07-29 陈璞 用于结缔组织生长因子的小干扰rna及其应用
CN115282262B (zh) * 2022-08-16 2024-07-12 四川大学华西医院 一种用于皮肤缺损治疗的组合物

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HUE044178T4 (hu) 2019-10-28
AU2018260886A1 (en) 2018-11-29
HUE044178T2 (hu) 2019-10-28
KR20130120537A (ko) 2013-11-04
CN103635197A (zh) 2014-03-12
TW201244724A (en) 2012-11-16
JP2018150351A (ja) 2018-09-27
IL227714A0 (en) 2013-09-30
US20170022501A1 (en) 2017-01-26
KR101697396B1 (ko) 2017-01-17
MX2013008963A (es) 2014-01-08
EP2670411A4 (en) 2014-07-16
US20200190521A1 (en) 2020-06-18
JP6177692B2 (ja) 2017-08-09
AU2012212110A1 (en) 2013-08-01
PT2670411T (pt) 2019-06-18
EP2670411A1 (en) 2013-12-11
SI2670411T1 (sl) 2019-06-28
AU2017202852A1 (en) 2017-05-18
TWI593416B (zh) 2017-08-01
RU2013134403A (ru) 2015-03-10
CA2825059A1 (en) 2012-08-09
JP2014505704A (ja) 2014-03-06
EP2670411B1 (en) 2019-04-10
BR112013019803A2 (pt) 2019-06-11
WO2012106508A1 (en) 2012-08-09
PL2670411T3 (pl) 2019-09-30
JP2017137325A (ja) 2017-08-10

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