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MX357289B - Diacuerpos covalentes y sus usos. - Google Patents

Diacuerpos covalentes y sus usos.

Info

Publication number
MX357289B
MX357289B MX2014009493A MX2014009493A MX357289B MX 357289 B MX357289 B MX 357289B MX 2014009493 A MX2014009493 A MX 2014009493A MX 2014009493 A MX2014009493 A MX 2014009493A MX 357289 B MX357289 B MX 357289B
Authority
MX
Mexico
Prior art keywords
same
diabody
molecules
molecule
antigens
Prior art date
Application number
MX2014009493A
Other languages
English (en)
Inventor
s johnson Leslie
Huang Ling
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of MX357289B publication Critical patent/MX357289B/es

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Abstract

La presente invención se refiere a moléculas de diacuerpo y sus usos en el tratamiento de una variedad de enfermedades y trastornos, que incluyen trastornos inmunolágicos, enfermedad infecciosa, intoxicación, y cánceres. Las moléculas de diacuerpo de la invención comprenden dos cadenas de polipéptido que se asocian para formar al menos dos sitios de unión de epítopo, que pueden reconocer el mismo o diferentes epítopos en el mismo o diferentes antígenos. Adicionalmente, los antígenos pueden formar la misma o diferentes moléculas. Las cadenas de polipéptido individuales de la molécula de diacuerpo pueden covalentemente unirse a través de enlaces covalente de unión no de péptido, tales como, pero no limitándose a el enlace de disulfuro de residuos de cisteína localizados dentro de cada cadena de polipéptido. En modalidades particulares, las moléculas de diacuerpo de la presente invención además comprenden una región Fc, que permite la funcionalidad de tipo anticuerpo para modificarse dentro de la molécula.
MX2014009493A 2008-12-19 2009-12-17 Diacuerpos covalentes y sus usos. MX357289B (es)

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JP6282717B2 (ja) 2018-02-21
JP2012512894A (ja) 2012-06-07
EP3482769A1 (en) 2019-05-15
ES2732191T3 (es) 2019-11-21
EP2786762A2 (en) 2014-10-08
EP2786762B1 (en) 2019-01-30
BRPI0918122A2 (pt) 2015-11-24
EP2786762A3 (en) 2015-07-29
DK2786762T3 (da) 2019-05-06
JP2015157833A (ja) 2015-09-03
RU2016127552A (ru) 2018-12-06
EP3482769B1 (en) 2024-05-29
RU2593720C2 (ru) 2016-08-10
HRP20190740T1 (hr) 2019-06-28
IL253751B (en) 2019-10-31
BRPI0918122A8 (pt) 2017-01-24
IL269454B (en) 2021-05-31
CN106432503A (zh) 2017-02-22
CN106220734A (zh) 2016-12-14
MX348166B (es) 2017-06-01
IL213348A0 (en) 2011-07-31
IL213348A (en) 2017-08-31
AU2009335798A1 (en) 2010-07-15
JP6059761B2 (ja) 2017-01-11
ES2733067T3 (es) 2019-11-27
SG172254A1 (en) 2011-07-28
KR20170090525A (ko) 2017-08-07
CN102369021A (zh) 2012-03-07
CY1122412T1 (el) 2021-01-27
WO2010080538A1 (en) 2010-07-15
HUE043084T2 (hu) 2019-08-28
LT2786762T (lt) 2019-06-10
CN102369021B (zh) 2016-09-07
ZA201103699B (en) 2012-04-25
ES2986435T3 (es) 2024-11-11
EP2376109A1 (en) 2011-10-19
IL253751A0 (en) 2017-09-28
KR101940059B1 (ko) 2019-01-18
CA2745460C (en) 2021-07-13
MX2011006416A (es) 2011-07-12
SG10201407908VA (en) 2015-01-29
JP2017105779A (ja) 2017-06-15
KR20110104032A (ko) 2011-09-21
CA2745460A1 (en) 2010-07-15
RU2016127552A3 (es) 2020-06-30
CL2011001449A1 (es) 2012-04-20
RU2744176C2 (ru) 2021-03-03

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