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MX354373B - Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales. - Google Patents

Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales.

Info

Publication number
MX354373B
MX354373B MX2014013855A MX2014013855A MX354373B MX 354373 B MX354373 B MX 354373B MX 2014013855 A MX2014013855 A MX 2014013855A MX 2014013855 A MX2014013855 A MX 2014013855A MX 354373 B MX354373 B MX 354373B
Authority
MX
Mexico
Prior art keywords
salts
making
compounds
cyclopentapyrimidine compounds
hydroxylated cyclopentapyrimidine
Prior art date
Application number
MX2014013855A
Other languages
English (en)
Other versions
MX2014013855A (es
Inventor
Srinivasan Babu
Francis Gosselin
Yingqing Ran
Travis Remarchuk
Scott J Savage
Jeffrey Stults
Herbert Yajima
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2014013855A publication Critical patent/MX2014013855A/es
Publication of MX354373B publication Critical patent/MX354373B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a nuevos procesos para elaborar y purificar sales de compuestos de ciclopentapirimidina hidroxilada, mismas que son útiles como inhibidores de AKT usados en el tratamiento de enfermedades como el cáncer, que incluyen la sal de monohidrocloruro de (S) -2- (4-clorofenil) -1- (4- ((5R, 7R) -7-hidroxi-5-metil-6,7-dihidro-5H-ciclopenta[d]pirimidin-4-il) piperazin-1-il) -3-(isopropilamino) propan-1-ona.
MX2014013855A 2012-05-17 2013-05-17 Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales. MX354373B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261648535P 2012-05-17 2012-05-17
PCT/US2013/041695 WO2013173784A1 (en) 2012-05-17 2013-05-17 Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof

Publications (2)

Publication Number Publication Date
MX2014013855A MX2014013855A (es) 2016-03-21
MX354373B true MX354373B (es) 2018-02-28

Family

ID=48534508

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013855A MX354373B (es) 2012-05-17 2013-05-17 Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales.

Country Status (18)

Country Link
US (1) US9315471B2 (es)
EP (1) EP2850200A1 (es)
JP (1) JP6355625B2 (es)
KR (1) KR102123131B1 (es)
CN (1) CN104471070B (es)
AU (1) AU2013262521B2 (es)
BR (1) BR112014028573B1 (es)
CA (1) CA2873661C (es)
HK (1) HK1208500A1 (es)
IL (1) IL235699B (es)
MA (1) MA37647A1 (es)
MX (1) MX354373B (es)
MY (1) MY169029A (es)
NZ (1) NZ702950A (es)
RU (1) RU2642311C2 (es)
SG (1) SG11201407591PA (es)
WO (1) WO2013173784A1 (es)
ZA (1) ZA201409226B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9278917B2 (en) 2012-05-17 2016-03-08 Genentech, Inc. Process for making amino acid compounds
EP2861583B1 (en) 2012-05-17 2016-06-29 Array Biopharma, Inc. Process for making hydroxylated cyclopentylpyrimidine compounds
KR20210095238A (ko) 2012-05-17 2021-07-30 제넨테크, 인크. 무정형 형태의 akt 저해성 피리미디닐 - 사이클로펜탄 화합물, 조성물 및 이들의 방법
MY169028A (en) 2012-05-17 2019-02-04 Genentech Inc Process for making hydroxylated cyclopentylpyrimidine compounds
CN110590606B (zh) 2013-11-15 2023-02-17 豪夫迈·罗氏有限公司 用于制备嘧啶基环戊烷化合物的方法
ES2749100T3 (es) 2014-09-26 2020-03-19 Hoffmann La Roche Procesos para preparar compuestos de (ciclopentil[d]pirimidin-4-il)piperazina
BR112019002007B1 (pt) 2016-08-10 2024-01-16 F. Hoffmann-La Roche Ag Composição farmacêutica e uso de uma composição farmacêutica
US20220025424A1 (en) * 2016-08-16 2022-01-27 Imago Biosciences, Inc. Compositions and methods for producing stereoisomerically pure aminocyclopropanes
WO2019122421A1 (en) * 2017-12-22 2019-06-27 Astrazeneca Ab Stereoselective ketone reduction using a ketoreductase enzyme
US20230271958A1 (en) * 2020-07-22 2023-08-31 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE
CA3186565A1 (en) * 2020-07-22 2022-01-27 Lei Miao Unit dosage composition of akt inhibitor
WO2023043869A1 (en) 2021-09-15 2023-03-23 Teva Pharmaceuticals International Gmbh Solid state forms of ipatasertib citrate

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WO1995015684A1 (en) 1993-12-12 1995-06-15 Agrogene, Ltd. A novel method to protect plants from fungal infection
WO1998044797A1 (en) 1997-04-07 1998-10-15 Merck & Co., Inc. A method of treating cancer
US6201023B1 (en) 1997-06-10 2001-03-13 Agrogene Ltd. Methods and compositions to protect crops against plant parasitic nematodes
AU1302999A (en) 1997-11-04 1999-05-24 Eli Lilly And Company Ketoreductase gene and protein from yeast
EP0982300A3 (en) 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
WO2000052134A2 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU7715300A (en) 1999-09-27 2001-04-30 Merck & Co., Inc. Method of preventing osteoporosis
DE10119274A1 (de) * 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
US7582766B2 (en) 2003-06-09 2009-09-01 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus
EP1898903B8 (en) * 2005-06-10 2013-05-15 Merck Sharp & Dohme Corp. Inhibitors of akt activity
US8927546B2 (en) 2006-02-28 2015-01-06 Dart Neuroscience (Cayman) Ltd. Therapeutic piperazines
UA95641C2 (en) 2006-07-06 2011-08-25 Эррей Биофарма Инк. Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
WO2009036404A2 (en) * 2007-09-13 2009-03-19 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
WO2009047255A1 (en) 2007-10-09 2009-04-16 Ucb Pharma, S.A. Heterobicyclic compounds as histamine h4-receptor antagonists
NZ586720A (en) 2008-01-09 2012-11-30 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
MX2011010905A (es) 2009-04-15 2011-11-01 Abbott Lab Compuestos antivirales.
US8436002B2 (en) 2009-10-23 2013-05-07 Eli Lilly And Company AKT inhibitors
PT2592933T (pt) 2010-07-16 2017-05-23 Gaweco Anderson Inibidores de mif e suas utilizações
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EP2861583B1 (en) 2012-05-17 2016-06-29 Array Biopharma, Inc. Process for making hydroxylated cyclopentylpyrimidine compounds
MY169028A (en) 2012-05-17 2019-02-04 Genentech Inc Process for making hydroxylated cyclopentylpyrimidine compounds
US9278917B2 (en) 2012-05-17 2016-03-08 Genentech, Inc. Process for making amino acid compounds
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Also Published As

Publication number Publication date
NZ702950A (en) 2016-09-30
MA37647A1 (fr) 2016-03-31
RU2014151014A (ru) 2016-07-10
JP6355625B2 (ja) 2018-07-11
AU2013262521A1 (en) 2015-01-22
WO2013173784A1 (en) 2013-11-21
CN104471070A (zh) 2015-03-25
CA2873661C (en) 2020-07-21
SG11201407591PA (en) 2015-01-29
BR112014028573A2 (pt) 2018-04-24
US20150099880A1 (en) 2015-04-09
KR20150018579A (ko) 2015-02-23
US9315471B2 (en) 2016-04-19
CA2873661A1 (en) 2013-11-21
EP2850200A1 (en) 2015-03-25
IL235699B (en) 2018-12-31
HK1208500A1 (en) 2016-03-04
ZA201409226B (en) 2017-09-27
RU2642311C2 (ru) 2018-01-24
MY169029A (en) 2019-02-04
BR112014028573B1 (pt) 2021-11-16
KR102123131B1 (ko) 2020-06-15
MX2014013855A (es) 2016-03-21
JP2015518715A (ja) 2015-07-06
IL235699A0 (en) 2015-01-29
CN104471070B (zh) 2018-09-25
AU2013262521B2 (en) 2017-03-02

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