[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

MX341690B - Conjugados de oligomero-calciomimetico y compuestos relacionados. - Google Patents

Conjugados de oligomero-calciomimetico y compuestos relacionados.

Info

Publication number
MX341690B
MX341690B MX2012003775A MX2012003775A MX341690B MX 341690 B MX341690 B MX 341690B MX 2012003775 A MX2012003775 A MX 2012003775A MX 2012003775 A MX2012003775 A MX 2012003775A MX 341690 B MX341690 B MX 341690B
Authority
MX
Mexico
Prior art keywords
calcimimetic
oligomer
conjugates
related compounds
conjugate
Prior art date
Application number
MX2012003775A
Other languages
English (en)
Other versions
MX2012003775A (es
Inventor
Jennifer Riggs-Sauthier
Lin Cheng
David Martin
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of MX2012003775A publication Critical patent/MX2012003775A/es
Publication of MX341690B publication Critical patent/MX341690B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/04—Calcium compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a un conjugado que comprende un calciomimético, incluido el cinacalcet, unido covalentemente mediante un conector a un oligómero o polímero hidrosoluble no peptídico, preferentemente a poli(etilenglicol).
MX2012003775A 2009-09-29 2010-09-29 Conjugados de oligomero-calciomimetico y compuestos relacionados. MX341690B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24693109P 2009-09-29 2009-09-29
PCT/US2010/050761 WO2011056325A2 (en) 2009-09-29 2010-09-29 Oligomer-calcimimetic conjugates and related compounds

Publications (2)

Publication Number Publication Date
MX2012003775A MX2012003775A (es) 2012-06-12
MX341690B true MX341690B (es) 2016-08-29

Family

ID=43901165

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012003775A MX341690B (es) 2009-09-29 2010-09-29 Conjugados de oligomero-calciomimetico y compuestos relacionados.

Country Status (9)

Country Link
EP (1) EP2482855B1 (es)
JP (1) JP5792175B2 (es)
KR (1) KR101828613B1 (es)
CN (1) CN102573921B (es)
AU (1) AU2010315805B2 (es)
CA (1) CA2773353C (es)
IL (1) IL218869A (es)
MX (1) MX341690B (es)
WO (1) WO2011056325A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8722732B2 (en) 2009-09-29 2014-05-13 Nektar Therapeutics Oligomer-calcimimetic conjugates and related compounds
JP2020105072A (ja) * 2017-03-24 2020-07-09 協和キリン株式会社 ポリエチレングリコール誘導体
WO2020067507A1 (ja) * 2018-09-28 2020-04-02 生化学工業株式会社 第１級アミン化合物又は第２級アミン化合物－酸性多糖コンジュゲートとその製造方法
JP7440132B2 (ja) * 2020-09-10 2024-02-28 シャンシー・ミコ・テクノロジー・カンパニー・リミテッド 二重特異性融合ポリペプチド化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966988A (en) 1989-02-17 1990-10-30 Chevron Research Company Process for preparing acetonitrile 3-trifluoromethyl benzene
US6011068A (en) 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
CZ290670B6 (cs) 1994-10-21 2002-09-11 Nps Pharmaceuticals, Inc. Sloučeniny modulující receptory anorganických iontů a farmaceutický prostředek, který je obsahuje
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US5648541A (en) 1995-09-28 1997-07-15 Nps Pharmaceuticals, Inc. Chiral reductions of imines leading to the syntheses of optically active amines
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
CN102895666B (zh) * 2003-12-16 2015-08-19 尼克塔治疗公司 化学改性的小分子
ATE443038T1 (de) 2005-05-16 2009-10-15 Teva Pharma Verfahren zur herstellung von cinacalcet hydrochlorid
PT2279758E (pt) 2005-06-16 2015-05-27 Nektar Therapeutics Conjugados possuindo uma ligação degradável e reagentes poliméricos úteis na preparação de tais conjugados
US7563930B2 (en) 2005-11-22 2009-07-21 Teva Pharmaceutical Industries Ltd Crystal forms of Cinacalcet HCI and processes for their preparation
CA2649245A1 (en) 2006-04-27 2007-11-08 Teva Pharmaceutical Industries Ltd. Process for the preparation of cinacalcet base
WO2008121386A2 (en) * 2007-03-30 2008-10-09 Amgen Inc. Calcimimetic compounds for use in the treatment of bowel disorders
WO2009151590A2 (en) * 2008-06-09 2009-12-17 Nektar Therapeutics Methods of treating cyp2d6 alternative metabolizers

Also Published As

Publication number Publication date
WO2011056325A2 (en) 2011-05-12
AU2010315805B2 (en) 2015-09-17
EP2482855B1 (en) 2017-12-27
CN102573921B (zh) 2015-11-25
KR101828613B1 (ko) 2018-02-12
CN102573921A (zh) 2012-07-11
WO2011056325A3 (en) 2011-09-29
EP2482855A2 (en) 2012-08-08
AU2010315805A1 (en) 2012-03-15
CA2773353C (en) 2018-02-27
MX2012003775A (es) 2012-06-12
JP2013505966A (ja) 2013-02-21
IL218869A0 (en) 2012-06-28
CA2773353A1 (en) 2011-05-12
IL218869A (en) 2016-12-29
JP5792175B2 (ja) 2015-10-07
KR20120090961A (ko) 2012-08-17

Similar Documents

Publication Publication Date Title
WO2011062965A3 (en) Targeting monomers and polymers having targeting blocks
WO2006138572A3 (en) Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
WO2017112825A3 (en) Polymer conjugates having reduced antigenicity and methods of using the same
EP2151461A3 (en) Benzylated polyalkylene polyamines and uses thereof
WO2010149484A3 (en) Oral care compositions comprising a dye polymer
WO2013173337A3 (en) Self-stabilizing linker conjugates
IL217392A (en) Asparaginase conjugates - l that have been pegilated, preparations containing them and uses
HK1198485A1 (en) Molecular conjugate
IL217828A0 (en) Biosphonic acid-comprising molecular complexes, compositions comprising the same and uses thereof
WO2011059326A3 (en) Hydrogels based on polymers of dextran tyramine and tyramine conjugates of natural polymers
IL202554A0 (en) Adducts, adducts and oligomers, or adducts, oligomers and low molecular weight polymers, and their preparation
WO2009120893A3 (en) Polypeptide-polymer conjugates and methods of use thereof
WO2010033240A3 (en) Carbohydrate-based drug delivery polymers and conjugates thereof
NZ588884A (en) Cross-linkers and their uses
WO2010062416A8 (en) Coupling agents and compositions produced using them
WO2009123969A3 (en) Deoxybenzoin-derived anti-flammable polymers
AP2012006062A0 (en) Pesticide compositions including polymeric adjuvants.
SG158060A1 (en) Compositions comprising an ultraviolet radiation-absorbing polymer
MX2010004400A (es) Polimeros de multiples brazos dirigidos a la hidroxiapatita y conjugados de estos.
WO2009010842A3 (en) Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
IL215722A0 (en) Pelletized low molecular weight brominated aromatic polymer compositions
MX341690B (es) Conjugados de oligomero-calciomimetico y compuestos relacionados.
MX2012010448A (es) Conjugados de carbohidrato-poli aminoacido-farmaco.
IL215721A0 (en) Pelletized low molecular weight brominated aromatic polymer compositions
IL209337A (en) Polymer couplers and cholinesterase group, preparations containing them and methods for making them

Legal Events

Date Code Title Description
FG Grant or registration