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MX347348B - Sintesis de derivados de 2-carboxamida-cicloamino-urea. - Google Patents

Sintesis de derivados de 2-carboxamida-cicloamino-urea.

Info

Publication number
MX347348B
MX347348B MX2013010132A MX2013010132A MX347348B MX 347348 B MX347348 B MX 347348B MX 2013010132 A MX2013010132 A MX 2013010132A MX 2013010132 A MX2013010132 A MX 2013010132A MX 347348 B MX347348 B MX 347348B
Authority
MX
Mexico
Prior art keywords
synthesis
urea derivatives
carboxamide cycloamino
cycloamino urea
carboxamide
Prior art date
Application number
MX2013010132A
Other languages
English (en)
Other versions
MX2013010132A (es
Inventor
Erb Bernhard
Sylvie Gallou Isabelle
Karl Kleinbeck Florian
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45787206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX347348(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2013010132A publication Critical patent/MX2013010132A/es
Publication of MX347348B publication Critical patent/MX347348B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26Radicals substituted by halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

En la presente se proporcionan procesos y compuestos intermediarios útiles para la preparación de los derivados de 2-carboxamida-cicloamino-urea de la fórmula (X): (Ver Formula) y de los intermediarios útiles para los mismos.
MX2013010132A 2011-03-03 2012-03-01 Sintesis de derivados de 2-carboxamida-cicloamino-urea. MX347348B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161448774P 2011-03-03 2011-03-03
PCT/EP2012/053559 WO2012117071A1 (en) 2011-03-03 2012-03-01 Synthesis of 2-carboxamide cycloamino urea derivatives

Publications (2)

Publication Number Publication Date
MX2013010132A MX2013010132A (es) 2013-10-30
MX347348B true MX347348B (es) 2017-04-17

Family

ID=45787206

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013010132A MX347348B (es) 2011-03-03 2012-03-01 Sintesis de derivados de 2-carboxamida-cicloamino-urea.
MX2017005292A MX351740B (es) 2011-03-03 2012-03-01 Sintesis de derivados de 2-carboxamida-cicloamino-urea.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2017005292A MX351740B (es) 2011-03-03 2012-03-01 Sintesis de derivados de 2-carboxamida-cicloamino-urea.

Country Status (32)

Country Link
US (3) US9650373B2 (es)
EP (1) EP2681192B1 (es)
JP (1) JP6022485B2 (es)
KR (1) KR101851421B1 (es)
CN (2) CN106083840B (es)
AR (2) AR088714A1 (es)
AU (1) AU2012222346B2 (es)
BR (1) BR112013021882A2 (es)
CA (1) CA2828509C (es)
CL (1) CL2013002521A1 (es)
CO (1) CO6751286A2 (es)
DK (1) DK2681192T3 (es)
EA (4) EA032802B1 (es)
EC (1) ECSP13012914A (es)
ES (1) ES2663717T3 (es)
GT (1) GT201300211A (es)
HU (1) HUE036319T2 (es)
IL (1) IL228023A (es)
MA (1) MA34982B1 (es)
MX (2) MX347348B (es)
MY (1) MY163214A (es)
NO (1) NO2681192T3 (es)
PE (1) PE20140917A1 (es)
PL (1) PL2681192T3 (es)
PT (1) PT2681192T (es)
SG (1) SG192793A1 (es)
SI (1) SI2681192T1 (es)
TN (1) TN2013000354A1 (es)
TW (2) TWI607994B (es)
UA (1) UA112539C2 (es)
WO (1) WO2012117071A1 (es)
ZA (1) ZA201306174B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA112539C2 (uk) * 2011-03-03 2016-09-26 Новартіс Аг Спосіб одержання похідних 2-карбоксамідциклоаміносечовини
BR112017009876A2 (pt) * 2014-11-14 2017-12-19 Gemphire Therapeutics Inc processos e intermediários para a preparação de éteres de dialcano terminados em ácido alfa,ômega-dicarboxílico
JP7014737B2 (ja) 2017-01-20 2022-02-01 株式会社ペーターズ スケートボード用ハンドル及びハンドル付きスケートボード
CN112961090A (zh) * 2019-12-13 2021-06-15 武汉九州钰民医药科技有限公司 合成Alpelisib的关键中间体及其制备方法
CN111057051A (zh) * 2019-12-16 2020-04-24 武汉九州钰民医药科技有限公司 PI3K抑制剂Alpelisib的新合成方法
CN110964005A (zh) * 2019-12-16 2020-04-07 武汉九州钰民医药科技有限公司 一种Alpelisib的制备工艺
KR20220125753A (ko) 2021-03-05 2022-09-14 배성륭 기능성 풍력 발전시스템

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3534056A (en) * 1967-03-02 1970-10-13 Pennwalt Corp Fluoro-alkyl pyridines and their preparation
UA60365C2 (uk) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
DE60023926T2 (de) 1999-09-10 2006-07-20 Merck & Co., Inc. Tyrosin kinase inhibitoren
AR044519A1 (es) * 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
WO2007087427A2 (en) * 2006-01-25 2007-08-02 Synta Pharmaceuticals Corp. Thiazole and thiadiazole compounds for inflammation and immune-related uses
TWI428091B (zh) 2007-10-23 2014-03-01 Du Pont 殺真菌劑混合物
PA8809001A1 (es) * 2007-12-20 2009-07-23 Novartis Ag Compuestos organicos
WO2009080649A2 (en) * 2007-12-21 2009-07-02 Telefonaktiebolaget Lm Ericsson (Publ) Improvements in or relating to wireless mobility
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
UA112539C2 (uk) * 2011-03-03 2016-09-26 Новартіс Аг Спосіб одержання похідних 2-карбоксамідциклоаміносечовини

Also Published As

Publication number Publication date
PT2681192T (pt) 2018-04-02
MX351740B (es) 2017-10-26
US10059670B2 (en) 2018-08-28
US9650373B2 (en) 2017-05-16
TN2013000354A1 (en) 2015-01-20
BR112013021882A2 (pt) 2016-07-19
SI2681192T1 (en) 2018-04-30
TWI607994B (zh) 2017-12-11
MA34982B1 (fr) 2014-03-01
KR101851421B1 (ko) 2018-04-23
IL228023A0 (en) 2013-09-30
ZA201306174B (en) 2014-05-28
IL228023A (en) 2017-04-30
UA112539C2 (uk) 2016-09-26
US20130331579A1 (en) 2013-12-12
NO2681192T3 (es) 2018-05-26
JP6022485B2 (ja) 2016-11-09
EA201792068A2 (ru) 2018-01-31
CN103402982A (zh) 2013-11-20
TWI597279B (zh) 2017-09-01
PL2681192T3 (pl) 2018-06-29
CL2013002521A1 (es) 2014-02-14
AR123584A2 (es) 2022-12-21
AR088714A1 (es) 2014-07-02
EA201792068A3 (ru) 2018-05-31
TW201722916A (zh) 2017-07-01
EP2681192B1 (en) 2017-12-27
NZ614173A (en) 2015-04-24
ECSP13012914A (es) 2013-11-29
PE20140917A1 (es) 2014-08-14
EA025381B1 (ru) 2016-12-30
EP2681192A1 (en) 2014-01-08
JP2014511387A (ja) 2014-05-15
MX2013010132A (es) 2013-10-30
DK2681192T3 (en) 2018-04-16
AU2012222346B2 (en) 2015-05-07
TW201247660A (en) 2012-12-01
ES2663717T3 (es) 2018-04-16
AU2012222346A1 (en) 2013-08-29
CN106083840B (zh) 2020-01-03
EA201892052A1 (ru) 2019-02-28
KR20140009432A (ko) 2014-01-22
WO2012117071A1 (en) 2012-09-07
GT201300211A (es) 2014-12-30
SG192793A1 (en) 2013-09-30
CO6751286A2 (es) 2013-09-16
US9776966B2 (en) 2017-10-03
US20170240509A1 (en) 2017-08-24
MY163214A (en) 2017-08-30
CN103402982B (zh) 2016-07-13
US20170355677A1 (en) 2017-12-14
EA201691331A1 (ru) 2017-01-30
CA2828509A1 (en) 2012-09-07
EA032802B1 (ru) 2019-07-31
EA201391267A1 (ru) 2014-01-30
CA2828509C (en) 2018-11-20
HUE036319T2 (hu) 2018-06-28
CN106083840A (zh) 2016-11-09

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