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MX2024004437A - Composiciones de inhibidor de la angiotensina-receptor neprilisina (arni) de administracion extrahepatica y metodos de uso de las mismas. - Google Patents

Composiciones de inhibidor de la angiotensina-receptor neprilisina (arni) de administracion extrahepatica y metodos de uso de las mismas.

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Publication number
MX2024004437A
MX2024004437A MX2024004437A MX2024004437A MX2024004437A MX 2024004437 A MX2024004437 A MX 2024004437A MX 2024004437 A MX2024004437 A MX 2024004437A MX 2024004437 A MX2024004437 A MX 2024004437A MX 2024004437 A MX2024004437 A MX 2024004437A
Authority
MX
Mexico
Prior art keywords
methods
extra
strand
antisense strand
complementary
Prior art date
Application number
MX2024004437A
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English (en)
Inventor
Martin A Maier
Ivan Zlatev
Vasant R Jadhav
Elena Castellanos-Rizaldos
Lucas D Bondurant
Karyn Schmidt
Jayaprakash K Nair
Justin Pierson
Yesseinia Anglero-Rodriguez
Kevin Dooley
Masaaki Nakata
Alexander Kel’In
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2024004437A publication Critical patent/MX2024004437A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12Y207/11017—Ca2+/Calmodulin-dependent protein kinase (2.7.11.17)

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Abstract

La presente invención proporciona agentes de ácido ribonucleico de cadena doble (ARNcd) para inhibir la expresión de un gen diana, que comprende una cadena antisentido que es complementaria al gen diana; una cadena homosentido que es complementaria a la cadena antisentido y forma una región de doble cadena con la cadena antisentido; y una o más cadenas de hidrocarburos C22 conjugadas con una o más posiciones internas en al menos una cadena, composiciones que comprenden los agentes de ARNcd, y métodos de uso de los mismos para tratar a un sujeto que tiene un trastorno del músculo esquelético, un trastorno del músculo cardíaco o un trastorno del tejido adiposo.
MX2024004437A 2021-10-15 2022-10-14 Composiciones de inhibidor de la angiotensina-receptor neprilisina (arni) de administracion extrahepatica y metodos de uso de las mismas. MX2024004437A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163255984P 2021-10-15 2021-10-15
PCT/US2022/046668 WO2023064530A1 (en) 2021-10-15 2022-10-14 Extra-hepatic delivery irna compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2024004437A true MX2024004437A (es) 2024-07-01

Family

ID=84360072

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2024004437A MX2024004437A (es) 2021-10-15 2022-10-14 Composiciones de inhibidor de la angiotensina-receptor neprilisina (arni) de administracion extrahepatica y metodos de uso de las mismas.

Country Status (10)

Country Link
US (1) US20240360455A1 (es)
EP (1) EP4416284A1 (es)
JP (1) JP2024539629A (es)
KR (1) KR20240101590A (es)
CN (1) CN118369427A (es)
AU (1) AU2022364838A1 (es)
CA (1) CA3234887A1 (es)
IL (1) IL311864A (es)
MX (1) MX2024004437A (es)
WO (1) WO2023064530A1 (es)

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