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MX2022007905A - Administracion transitoria basada en temperatura de acidos nucleicos y proteinas a celulas y tejidos. - Google Patents

Administracion transitoria basada en temperatura de acidos nucleicos y proteinas a celulas y tejidos.

Info

Publication number
MX2022007905A
MX2022007905A MX2022007905A MX2022007905A MX2022007905A MX 2022007905 A MX2022007905 A MX 2022007905A MX 2022007905 A MX2022007905 A MX 2022007905A MX 2022007905 A MX2022007905 A MX 2022007905A MX 2022007905 A MX2022007905 A MX 2022007905A
Authority
MX
Mexico
Prior art keywords
temperature
cells
subject
sensitive
methods
Prior art date
Application number
MX2022007905A
Other languages
English (en)
Inventor
Minoru S H Ko
Original Assignee
Elixirgen Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elixirgen Therapeutics Inc filed Critical Elixirgen Therapeutics Inc
Publication of MX2022007905A publication Critical patent/MX2022007905A/es

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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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Abstract

La presente descripción se refiere a métodos para activar transitoriamente agentes sensibles a la temperatura en una o más células, por ejemplo, al poner en contacto una o más células con un agente sensible a la temperatura y al incubar transitoriamente las células a una temperatura permisiva para inducir en las células una actividad del agente sensible a la temperatura. Adicionalmente, la presente descripción se refiere a métodos para poner en contacto una o más células en un sujeto con un agente sensible a la temperatura y luego reducir la temperatura corporal central del sujeto a una temperatura permisiva para inducir una actividad del agente sensible a la temperatura en las células. La descripción también se refiere a métodos para poner en contacto una o más células en un sujeto con un agente sensible a la temperatura, manteniendo la temperatura corporal superficial del sujeto a una temperatura permisiva para inducir en las células una actividad del agente sensible a la temperatura. Se describen adicionalmente métodos para tratar a un sujeto con un agente terapéutico sensible a la temperatura.
MX2022007905A 2019-12-31 2020-12-30 Administracion transitoria basada en temperatura de acidos nucleicos y proteinas a celulas y tejidos. MX2022007905A (es)

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