MX2020012503A - Métodos de tratamiento de neoplasias mieloproliferativas. - Google Patents
Métodos de tratamiento de neoplasias mieloproliferativas.Info
- Publication number
- MX2020012503A MX2020012503A MX2020012503A MX2020012503A MX2020012503A MX 2020012503 A MX2020012503 A MX 2020012503A MX 2020012503 A MX2020012503 A MX 2020012503A MX 2020012503 A MX2020012503 A MX 2020012503A MX 2020012503 A MX2020012503 A MX 2020012503A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitor
- treating
- methods
- mpn
- formula
- Prior art date
Links
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 title abstract 4
- 208000032027 Essential Thrombocythemia Diseases 0.000 abstract 2
- 208000017733 acquired polycythemia vera Diseases 0.000 abstract 2
- 208000037244 polycythemia vera Diseases 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 229940126638 Akt inhibitor Drugs 0.000 abstract 1
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 229940122245 Janus kinase inhibitor Drugs 0.000 abstract 1
- 239000012270 PD-1 inhibitor Substances 0.000 abstract 1
- 239000012668 PD-1-inhibitor Substances 0.000 abstract 1
- 239000012271 PD-L1 inhibitor Substances 0.000 abstract 1
- 239000012272 PD-L2 inhibitor Substances 0.000 abstract 1
- 239000012828 PI3K inhibitor Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 229940124302 mTOR inhibitor Drugs 0.000 abstract 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 abstract 1
- 206010028537 myelofibrosis Diseases 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 229940121655 pd-1 inhibitor Drugs 0.000 abstract 1
- 229940121656 pd-l1 inhibitor Drugs 0.000 abstract 1
- 229940121654 pd-l2 inhibitor Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 abstract 1
- 239000003197 protein kinase B inhibitor Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/804—Blood cells [leukemia, lymphoma]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen métodos terapéuticos y composiciones farmacéuticas para tratar una neoplasia mieloproliferativa (MPN), que incluye policitemia vera (PV), trombocitemia esencial (ET) y mielofibrosis. En ciertas modalidades, la invención incluye métodos terapéuticos para tratar una MPN mediante el uso de una combinación de un compuesto de Fórmula (I) o Fórmula (II) con un agente terapéutico seleccionado del grupo que consiste en un inhibidor de JAK, un inhibidor de IDH, un inhibidor de PD-1, un inhibidor de PD-L1, un inhibidor de PD-L2, un interferón, un inhibidor de PI3K, un inhibidor de AKT, un inhibidor de mTOR, un análogo de nucleósido y sus combinaciones.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862676495P | 2018-05-25 | 2018-05-25 | |
| US201862781923P | 2018-12-19 | 2018-12-19 | |
| US201962814781P | 2019-03-06 | 2019-03-06 | |
| US201962835311P | 2019-04-17 | 2019-04-17 | |
| PCT/IB2019/095002 WO2019224803A2 (en) | 2018-05-25 | 2019-05-25 | Methods of treating myeloproliferative neoplasms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020012503A true MX2020012503A (es) | 2021-08-11 |
Family
ID=68615938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020012503A MX2020012503A (es) | 2018-05-25 | 2019-05-25 | Métodos de tratamiento de neoplasias mieloproliferativas. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12268681B2 (es) |
| EP (1) | EP3801476A4 (es) |
| JP (2) | JP2021525795A (es) |
| KR (1) | KR20210043499A (es) |
| CN (1) | CN112804994A (es) |
| AU (2) | AU2019273850B2 (es) |
| CA (1) | CA3100973A1 (es) |
| MX (1) | MX2020012503A (es) |
| WO (1) | WO2019224803A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022003129A (es) * | 2019-09-16 | 2022-04-06 | Novartis Ag | Uso de un inhibidor de mdm2 para el tratamiento de la mielofibrosis. |
| EP4171512A1 (en) * | 2020-06-24 | 2023-05-03 | Novartis AG | Oral liquid formulations of ruxolitinib |
| CN114507234A (zh) * | 2020-10-13 | 2022-05-17 | 上海健康医学院 | 11c标记osi-027化合物及其制备方法及应用 |
| US20250092035A1 (en) * | 2022-01-25 | 2025-03-20 | The Wistar Institute Of Anatomy And Biology | Isocitrate dehydrogenase 1 inhibitors and methods of use thereof |
| WO2024031406A1 (en) * | 2022-08-10 | 2024-02-15 | Xiang Li | Idh mutations as biomarkers for zotiraciclib therapy |
| WO2024124240A1 (en) * | 2022-12-09 | 2024-06-13 | Kartos Therapeutics | Methods of treating myeloproliferative neoplasms |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE029188T2 (en) * | 2007-03-12 | 2017-03-28 | Ym Biosciences Australia Pty | Phenylamino-pyrimidine compounds and their use |
| KR20120108042A (ko) * | 2008-03-11 | 2012-10-04 | 인사이트 코포레이션 | Ｊａｋ 억제제로서의 아제티딘 및 시클로부탄 유도체 |
| IL317233A (en) | 2012-12-07 | 2025-01-01 | Geron Corp | Use of telomerase inhibitors to treat bone marrow culture disorders and bone marrow culture tumors |
| MX368703B (es) | 2013-02-28 | 2019-10-11 | Amgen Inc | Un inhibidor de mdm2 derivado de acido benzoico para el tratamiento del cancer. |
| US20140327948A1 (en) * | 2013-05-06 | 2014-11-06 | Pixtronix, Inc. | Display elements incorporating asymmetric apertures |
| JOP20200296A1 (ar) * | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| CA2930244A1 (en) * | 2013-11-11 | 2015-05-14 | Amgen Inc. | Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers |
| US20160331754A1 (en) * | 2014-01-20 | 2016-11-17 | Gilead Sciences, Inc. | Therapies for treating cancers |
| TW201613576A (en) * | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
| WO2017011371A1 (en) * | 2015-07-10 | 2017-01-19 | Arvinas, Inc | Mdm2-based modulators of proteolysis and associated methods of use |
-
2019
- 2019-05-25 WO PCT/IB2019/095002 patent/WO2019224803A2/en active IP Right Grant
- 2019-05-25 KR KR1020207036963A patent/KR20210043499A/ko active Pending
- 2019-05-25 US US17/057,913 patent/US12268681B2/en active Active
- 2019-05-25 MX MX2020012503A patent/MX2020012503A/es unknown
- 2019-05-25 EP EP19807406.4A patent/EP3801476A4/en active Pending
- 2019-05-25 AU AU2019273850A patent/AU2019273850B2/en active Active
- 2019-05-25 CN CN201980049262.8A patent/CN112804994A/zh active Pending
- 2019-05-25 CA CA3100973A patent/CA3100973A1/en active Pending
- 2019-05-25 JP JP2021515308A patent/JP2021525795A/ja active Pending
-
2025
- 2025-01-30 JP JP2025013469A patent/JP2025072429A/ja active Pending
- 2025-02-06 AU AU2025200802A patent/AU2025200802A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019224803A3 (en) | 2020-06-11 |
| WO2019224803A2 (en) | 2019-11-28 |
| EP3801476A2 (en) | 2021-04-14 |
| JP2021525795A (ja) | 2021-09-27 |
| JP2025072429A (ja) | 2025-05-09 |
| KR20210043499A (ko) | 2021-04-21 |
| CN112804994A (zh) | 2021-05-14 |
| AU2025200802A1 (en) | 2025-03-06 |
| AU2019273850B2 (en) | 2024-11-14 |
| US12268681B2 (en) | 2025-04-08 |
| AU2019273850A1 (en) | 2021-01-07 |
| US20220054472A1 (en) | 2022-02-24 |
| EP3801476A4 (en) | 2022-07-06 |
| CA3100973A1 (en) | 2019-11-28 |
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