MX2020006365A - Quinazolinonas como inhibidores de poli(adenosin difosfato-ribosa)polimerasa 14 (parp14). - Google Patents
Quinazolinonas como inhibidores de poli(adenosin difosfato-ribosa)polimerasa 14 (parp14).Info
- Publication number
- MX2020006365A MX2020006365A MX2020006365A MX2020006365A MX2020006365A MX 2020006365 A MX2020006365 A MX 2020006365A MX 2020006365 A MX2020006365 A MX 2020006365A MX 2020006365 A MX2020006365 A MX 2020006365A MX 2020006365 A MX2020006365 A MX 2020006365A
- Authority
- MX
- Mexico
- Prior art keywords
- quinazolinones
- parp14
- inhibitors
- parp14 inhibitors
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se relaciona con quinazolinonas y compuestos relacionados que son inhibidores de PARP14 y que son útiles, por ejemplo, en el tratamiento de cáncer y enfermedades inflamatorias.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762608747P | 2017-12-21 | 2017-12-21 | |
| US201862691025P | 2018-06-28 | 2018-06-28 | |
| PCT/US2018/066700 WO2019126443A1 (en) | 2017-12-21 | 2018-12-20 | Quinazolinones as parp14 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020006365A true MX2020006365A (es) | 2020-10-12 |
Family
ID=65013795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020006365A MX2020006365A (es) | 2017-12-21 | 2018-12-20 | Quinazolinonas como inhibidores de poli(adenosin difosfato-ribosa)polimerasa 14 (parp14). |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US10562891B2 (es) |
| EP (2) | EP4212515A1 (es) |
| JP (2) | JP7381485B2 (es) |
| KR (1) | KR20200103760A (es) |
| CN (1) | CN111699176A (es) |
| AU (2) | AU2018392616B2 (es) |
| BR (1) | BR112020012197A2 (es) |
| CA (1) | CA3085353A1 (es) |
| DK (1) | DK3728207T3 (es) |
| ES (1) | ES2941818T3 (es) |
| FI (1) | FI3728207T3 (es) |
| HR (1) | HRP20230183T1 (es) |
| HU (1) | HUE061595T2 (es) |
| IL (2) | IL314670A (es) |
| LT (1) | LT3728207T (es) |
| MD (1) | MD3728207T2 (es) |
| MX (1) | MX2020006365A (es) |
| PL (1) | PL3728207T3 (es) |
| PT (1) | PT3728207T (es) |
| RS (1) | RS64183B1 (es) |
| SI (1) | SI3728207T1 (es) |
| TW (1) | TWI813611B (es) |
| WO (1) | WO2019126443A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020012197A2 (pt) | 2017-12-21 | 2020-11-24 | Ribon Therapeutics Inc. | quinazolinonas como inibidores de parp14 |
| ES2980410T3 (es) | 2018-08-27 | 2024-10-01 | Univ Oregon Health & Science | Inhibidores de PARP para el tratamiento del cáncer y del asma |
| WO2021198191A1 (en) * | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| CN111423373B (zh) * | 2020-05-19 | 2024-01-19 | 瑞阳制药股份有限公司 | 硫酸羟氯喹的制备方法 |
| JP2024505228A (ja) | 2021-01-29 | 2024-02-05 | ライボン・セラピューティクス・インコーポレイテッド | 炎症性疾患を処置する方法 |
| CN115260164B (zh) * | 2021-05-01 | 2024-03-26 | 杭州星鳌生物科技有限公司 | 新型4(3h)-喹唑啉酮类似物的制备方法、结构组成及其在抗肿瘤药物中的应用 |
| TW202342463A (zh) | 2022-02-09 | 2023-11-01 | 美商律幫治療股份有限公司 | Parp14抑制劑之固體形式 |
| CN114634496B (zh) * | 2022-02-27 | 2024-04-19 | 复旦大学 | 吲哚酮取代-1,3-噻唑烷酮类衍生物及其制备方法和应用 |
| TW202417435A (zh) | 2022-07-29 | 2024-05-01 | 美商律幫治療股份有限公司 | 用於治療之parp14之靶向蛋白質降解 |
| TW202417434A (zh) | 2022-07-29 | 2024-05-01 | 美商律幫治療股份有限公司 | 用於治療之parp14之靶向蛋白質降解 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2607506B1 (fr) | 1986-12-02 | 1989-01-06 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| AUPR201600A0 (en) * | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
| GB0030708D0 (en) | 2000-12-15 | 2001-01-31 | Imperial College | Single channel proteomics concepts |
| AUPR975601A0 (en) * | 2001-12-24 | 2002-01-31 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivatives |
| US7452893B2 (en) | 2003-08-15 | 2008-11-18 | Merck & Co., Inc. | 4-cycloakylaminopyrazolo pyrimidine NMDA/NR2B antagonists |
| UY29161A1 (es) | 2004-10-15 | 2006-04-28 | Bayer Pharmaceuticals Corp | Nuevos heterociclos |
| GB0914767D0 (en) | 2009-08-24 | 2009-09-30 | Sterix Ltd | Compound |
| EP2480551A1 (en) | 2009-09-23 | 2012-08-01 | Pfizer Inc. | Gpr 119 modulators |
| EP2794608B1 (en) | 2011-12-22 | 2016-09-14 | Merck Patent GmbH | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
| ES2595240T3 (es) * | 2012-07-09 | 2016-12-28 | Lupin Limited | Derivados de tetrahidroquinazolinona como inhibidores de PARP |
| US9505749B2 (en) * | 2012-08-29 | 2016-11-29 | Amgen Inc. | Quinazolinone compounds and derivatives thereof |
| WO2014128655A1 (en) | 2013-02-25 | 2014-08-28 | Aurigene Discovery Technologies Limited | Substituted imidazo[4,5-c]quinoline derivatives as bromodomain inhibitors |
| LT3027598T (lt) * | 2013-07-31 | 2017-06-12 | Merck Patent Gmbh | Oksochinazolinil-butanamido dariniai |
| US10689651B2 (en) | 2013-11-14 | 2020-06-23 | The Brigham And Women's Hospital, Inc. | Method of inhibiting macrophage activation using an inhibitor of PARP9 |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| CA2946731C (en) | 2014-04-23 | 2022-06-07 | Incyte Corporation | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
| WO2017042380A1 (en) | 2015-09-11 | 2017-03-16 | Universite De Lille 2 Droit Et Sante | Novel 5-amino-2-thioimidazole compounds and their use |
| WO2017197056A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Bromodomain targeting degronimers for target protein degradation |
| GB201615282D0 (en) | 2016-09-08 | 2016-10-26 | Univ Bath | Tankyrase inhibitors |
| JP7260521B2 (ja) | 2017-07-12 | 2023-04-18 | ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド | タウタンパク質分解の化合物 |
| US11623932B2 (en) | 2017-09-22 | 2023-04-11 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| BR112020012197A2 (pt) | 2017-12-21 | 2020-11-24 | Ribon Therapeutics Inc. | quinazolinonas como inibidores de parp14 |
| US20200407700A1 (en) | 2018-02-26 | 2020-12-31 | President And Fellows Of Harvard College | Compositions of parp14 modulators and/or mutants and therapeutic use thereof |
| ES2980410T3 (es) | 2018-08-27 | 2024-10-01 | Univ Oregon Health & Science | Inhibidores de PARP para el tratamiento del cáncer y del asma |
| CA3142002A1 (en) * | 2019-06-19 | 2020-12-24 | Ribon Therapeutics, Inc. | Targeted protein degradation of parp14 for use in therapy |
| JP2024505228A (ja) | 2021-01-29 | 2024-02-05 | ライボン・セラピューティクス・インコーポレイテッド | 炎症性疾患を処置する方法 |
| TW202342463A (zh) * | 2022-02-09 | 2023-11-01 | 美商律幫治療股份有限公司 | Parp14抑制劑之固體形式 |
-
2018
- 2018-12-20 BR BR112020012197-5A patent/BR112020012197A2/pt unknown
- 2018-12-20 FI FIEP18833588.9T patent/FI3728207T3/fi active
- 2018-12-20 KR KR1020207021282A patent/KR20200103760A/ko not_active Application Discontinuation
- 2018-12-20 RS RS20230284A patent/RS64183B1/sr unknown
- 2018-12-20 JP JP2020554054A patent/JP7381485B2/ja active Active
- 2018-12-20 HR HRP20230183TT patent/HRP20230183T1/hr unknown
- 2018-12-20 EP EP22212226.9A patent/EP4212515A1/en active Pending
- 2018-12-20 LT LTEPPCT/US2018/066700T patent/LT3728207T/lt unknown
- 2018-12-20 DK DK18833588.9T patent/DK3728207T3/da active
- 2018-12-20 MD MDE20201102T patent/MD3728207T2/ro unknown
- 2018-12-20 MX MX2020006365A patent/MX2020006365A/es unknown
- 2018-12-20 EP EP18833588.9A patent/EP3728207B1/en active Active
- 2018-12-20 PT PT188335889T patent/PT3728207T/pt unknown
- 2018-12-20 US US16/227,132 patent/US10562891B2/en active Active
- 2018-12-20 CN CN201880088833.4A patent/CN111699176A/zh active Pending
- 2018-12-20 WO PCT/US2018/066700 patent/WO2019126443A1/en active Application Filing
- 2018-12-20 SI SI201830904T patent/SI3728207T1/sl unknown
- 2018-12-20 ES ES18833588T patent/ES2941818T3/es active Active
- 2018-12-20 PL PL18833588.9T patent/PL3728207T3/pl unknown
- 2018-12-20 TW TW107146131A patent/TWI813611B/zh active
- 2018-12-20 HU HUE18833588A patent/HUE061595T2/hu unknown
- 2018-12-20 IL IL314670A patent/IL314670A/en unknown
- 2018-12-20 CA CA3085353A patent/CA3085353A1/en active Pending
- 2018-12-20 AU AU2018392616A patent/AU2018392616B2/en active Active
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2020
- 2020-01-06 US US16/734,840 patent/US11008308B2/en active Active
- 2020-06-14 IL IL275331A patent/IL275331A/en unknown
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2021
- 2021-04-14 US US17/230,099 patent/US11958837B2/en active Active
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2023
- 2023-09-19 AU AU2023233066A patent/AU2023233066A1/en active Pending
- 2023-11-02 JP JP2023188422A patent/JP2024023224A/ja active Pending
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