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MX2020004538A - Moduladores de la vía de estrés integrada. - Google Patents

Moduladores de la vía de estrés integrada.

Info

Publication number
MX2020004538A
MX2020004538A MX2020004538A MX2020004538A MX2020004538A MX 2020004538 A MX2020004538 A MX 2020004538A MX 2020004538 A MX2020004538 A MX 2020004538A MX 2020004538 A MX2020004538 A MX 2020004538A MX 2020004538 A MX2020004538 A MX 2020004538A
Authority
MX
Mexico
Prior art keywords
modulators
integrated stress
stress pathway
integrated
pathway
Prior art date
Application number
MX2020004538A
Other languages
English (en)
Inventor
Zhang Qingwei
Lei Shi
Marina A Pliushchev
Michael J Dart
Yunsong Tong
Xiangdong Xu
Jennifer M Frost
Carmela Sidrauski
Kathleen Ann Martin
Zhaoming Xiong
Kathleen Murauski
Ramzi Farah Sweis
Original Assignee
Calico Life Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calico Life Sciences Llc filed Critical Calico Life Sciences Llc
Publication of MX2020004538A publication Critical patent/MX2020004538A/es

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/68—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/38—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing five carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/40—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
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Abstract

Se proporcionan en la presente compuestos de fórmula (I) y (II), composiciones y métodos de utilidad para modular la respuesta al estrés integrada (ISR) y para tratar enfermedades, trastornos y condiciones relacionados.
MX2020004538A 2017-11-02 2018-11-02 Moduladores de la vía de estrés integrada. MX2020004538A (es)

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MX2020006115A (es) 2017-12-13 2020-11-09 Praxis Biotech LLC Inhibidores de la vía de respuesta al estrés integrada.
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US11166942B2 (en) 2018-06-05 2021-11-09 Praxis Biotech LLC Inhibitors of integrated stress response pathway
TWI771621B (zh) 2018-10-11 2022-07-21 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
JP2022520236A (ja) 2019-02-13 2022-03-29 デナリ セラピューティクス インコーポレイテッド 化合物、組成物、及び、方法
MA54959A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
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AU2018360855B2 (en) 2023-04-06
CA3080804A1 (en) 2019-05-09
BR112020008817A2 (pt) 2020-10-13
SG11202004074TA (en) 2020-05-28
JP2021501790A (ja) 2021-01-21
AU2018360855A1 (en) 2020-06-04
BR112020008817B1 (pt) 2020-10-13
KR20200092332A (ko) 2020-08-03
WO2019090074A1 (en) 2019-05-09
CN112204006B (zh) 2023-11-28
IL274367B2 (en) 2023-10-01
IL274367A (en) 2020-06-30
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US20210393599A1 (en) 2021-12-23
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