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MX2018015251A - Derivados de 2-amino-4-(amino sustituido)fenil carbamato fluorinado. - Google Patents

Derivados de 2-amino-4-(amino sustituido)fenil carbamato fluorinado.

Info

Publication number
MX2018015251A
MX2018015251A MX2018015251A MX2018015251A MX2018015251A MX 2018015251 A MX2018015251 A MX 2018015251A MX 2018015251 A MX2018015251 A MX 2018015251A MX 2018015251 A MX2018015251 A MX 2018015251A MX 2018015251 A MX2018015251 A MX 2018015251A
Authority
MX
Mexico
Prior art keywords
amino
fluorinated
phenyl carbamate
carbamate derivatives
substituted amino
Prior art date
Application number
MX2018015251A
Other languages
English (en)
Inventor
C Askew Ben
Scott Edwards D
Furuya Takeru
Original Assignee
Scifluor Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scifluor Life Sciences Inc filed Critical Scifluor Life Sciences Inc
Publication of MX2018015251A publication Critical patent/MX2018015251A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La solicitud se refiere a derivados de 2-amino-4-(amino sustituido)fenil carbamato o sales o solvatos farmaceuticamente aceptables de los mismos como moduladores del canal de potasio de KCNQ2/3 y metodos de sus usos.
MX2018015251A 2016-06-10 2017-06-09 Derivados de 2-amino-4-(amino sustituido)fenil carbamato fluorinado. MX2018015251A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662348481P 2016-06-10 2016-06-10
PCT/US2017/036802 WO2017214539A1 (en) 2016-06-10 2017-06-09 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives

Publications (1)

Publication Number Publication Date
MX2018015251A true MX2018015251A (es) 2019-04-25

Family

ID=60572305

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018015251A MX2018015251A (es) 2016-06-10 2017-06-09 Derivados de 2-amino-4-(amino sustituido)fenil carbamato fluorinado.

Country Status (12)

Country Link
US (2) US20170355679A1 (es)
EP (1) EP3468947A4 (es)
JP (1) JP2019518754A (es)
KR (1) KR20190008411A (es)
CN (1) CN109641836A (es)
AU (1) AU2017278093B8 (es)
BR (1) BR112018075597A2 (es)
CA (1) CA3023340A1 (es)
IL (1) IL262855A (es)
MX (1) MX2018015251A (es)
RU (1) RU2018147263A (es)
WO (1) WO2017214539A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3023340A1 (en) 2016-06-10 2017-12-14 Scifluor Life Sciences, Inc. Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives
WO2019118657A1 (en) * 2017-12-13 2019-06-20 Scifluor Life Sciences, Inc. Fluorinated 4-(substituted amino)phenyl carbamate derivatives
UY38540A (es) 2019-01-14 2020-08-31 Pi Industries Ltd Compuestos de fenilamidina 3-sustituida, preparación y uso
EP4250926A1 (en) 2020-11-30 2023-10-04 PI Industries Ltd. Agrochemical composition comprising 3-substituted phenylamidine compounds and use thereof
WO2022198115A1 (en) * 2021-03-19 2022-09-22 Xyzagen, Inc. Prodrugs of kv7 channel openers
JP7294734B2 (ja) * 2021-10-27 2023-06-20 シャンハイ ジムン バイオファーマ，インコーポレーテッド カリウムチャネル調節剤としての化合物ならびにその調製および応用
CN113698345B (zh) * 2021-10-27 2022-02-01 上海挚盟医药科技有限公司 作为钾通道调节剂的化合物及其制备和应用
TW202333693A (zh) * 2021-12-31 2023-09-01 大陸商上海翰森生物醫藥科技有限公司 苯并哌啶衍生物調節劑、其製備方法和應用
CN116478068A (zh) * 2022-01-14 2023-07-25 中国科学院上海药物研究所 一种高选择性kcnq4钾通道激动剂、其制备方法和用途
CN116535353A (zh) * 2022-01-25 2023-08-04 上海挚盟医药科技有限公司 作为钾通道调节剂的酰胺类化合物及其制备和应用
TW202430510A (zh) * 2022-09-30 2024-08-01 大陸商上海翰森生物醫藥科技有限公司 含哌啶多環類衍生物調節劑、其製備方法和應用

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
GB9915414D0 (en) 1999-07-01 1999-09-01 Glaxo Group Ltd Medical use
AU2001270167A1 (en) 2000-06-30 2002-01-14 Fmc Corporation Steam injection heater and method
WO2003106454A1 (en) * 2002-06-12 2003-12-24 Orchid Chemicals & Pharmaceuticals Ltd 1h-isoquinoline-oxazolidinone derivaties and their use as antibacterial agents
UA89503C2 (uk) 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
US8790623B2 (en) 2005-01-18 2014-07-29 Il'Oreal Composition for treating keratin fibers, comprising at least one aromatic alcohol, at least one aromatic carboxylic acid, and at least one protecting agent
US8993593B2 (en) 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
DK2061465T3 (da) * 2006-08-23 2013-07-08 Valeant Pharmaceuticals Int Derivater af 4-(N-azacycloalkyl)anilider som kaliumkanalmodulatorer
EP2185149A1 (en) * 2007-08-01 2010-05-19 H. Lundbeck A/S Use of kncq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted
AU2008300827B2 (en) * 2007-09-19 2013-04-04 4Sc Ag Novel tetrahydrofusedpyridines as histone deacetylase inhibitors
CN103073455B (zh) * 2011-10-25 2015-08-19 中国科学院上海药物研究所 一类新型的kcnq钾通道激动剂、其制备方法和用途
CN103373941B (zh) * 2012-04-11 2016-08-17 浙江九洲药物科技有限公司 瑞替加滨及其中间体的制备方法
US8916133B2 (en) * 2012-04-30 2014-12-23 Scifluor Life Sciences, Llc Fluorinated 2-amino-4-(benzylamino)phenylcarbamate derivatives
CN108250128A (zh) 2012-09-27 2018-07-06 江苏先声药业有限公司 作为钾通道调节剂的化合物
CN105017085B (zh) 2014-04-28 2018-06-29 中国科学院上海药物研究所 一类kcnq钾通道激动剂、其制备方法和用途
US10526280B2 (en) * 2014-11-13 2020-01-07 University of Pittsburgh—of the Commonwealth System of Higher Education (2-amino-4-(arylamino)phenyl carbamates
CA3023340A1 (en) 2016-06-10 2017-12-14 Scifluor Life Sciences, Inc. Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives
WO2019118657A1 (en) 2017-12-13 2019-06-20 Scifluor Life Sciences, Inc. Fluorinated 4-(substituted amino)phenyl carbamate derivatives

Also Published As

Publication number Publication date
JP2019518754A (ja) 2019-07-04
EP3468947A1 (en) 2019-04-17
KR20190008411A (ko) 2019-01-23
US11858900B2 (en) 2024-01-02
AU2017278093B2 (en) 2021-12-16
IL262855A (en) 2018-12-31
BR112018075597A2 (pt) 2019-03-26
AU2017278093A1 (en) 2018-11-22
EP3468947A4 (en) 2020-01-08
CA3023340A1 (en) 2017-12-14
RU2018147263A (ru) 2020-07-10
AU2017278093B8 (en) 2021-12-23
US20170355679A1 (en) 2017-12-14
US20210309612A1 (en) 2021-10-07
CN109641836A (zh) 2019-04-16
WO2017214539A1 (en) 2017-12-14

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