MX2018009369A - Regulacion de expresion genica mediante control mediado por aptameros de ribozimas de autocorte. - Google Patents
Regulacion de expresion genica mediante control mediado por aptameros de ribozimas de autocorte.Info
- Publication number
- MX2018009369A MX2018009369A MX2018009369A MX2018009369A MX2018009369A MX 2018009369 A MX2018009369 A MX 2018009369A MX 2018009369 A MX2018009369 A MX 2018009369A MX 2018009369 A MX2018009369 A MX 2018009369A MX 2018009369 A MX2018009369 A MX 2018009369A
- Authority
- MX
- Mexico
- Prior art keywords
- gene expression
- aptamer
- regulation
- self
- cleaving ribozymes
- Prior art date
Links
- 108091023037 Aptamer Proteins 0.000 title abstract 5
- 108090000994 Catalytic RNA Proteins 0.000 title abstract 2
- 102000053642 Catalytic RNA Human genes 0.000 title abstract 2
- 230000014493 regulation of gene expression Effects 0.000 title abstract 2
- 108091092562 ribozyme Proteins 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title 1
- 230000014509 gene expression Effects 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 3
- 108020004422 Riboswitch Proteins 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/52—Vector systems having a special element relevant for transcription encoding ribozyme for self-inactivation
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La invención proporciona construcciones de polinucleótidos para regular la expresión génica mediante modulación a base de aptámeros de ribozimas de autocorte, así como métodos para utilizar las construcciones para regular la expresión génica en respuesta a la presencia o ausencia de un ligando que se una al aptámero. La invención proporciona adicionalmente métodos para realizar y utilizar riborreguladores que disminuyen la expresión del gen objetivo en respuesta a un ligando del aptámero, así como riborreguladores que aumentan la expresión del gen objetivo en respuesta a un ligando del aptámero.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662290187P | 2016-02-02 | 2016-02-02 | |
| US201662290209P | 2016-02-02 | 2016-02-02 | |
| PCT/US2017/016303 WO2017136608A2 (en) | 2016-02-02 | 2017-02-02 | Regulation of gene expression via aptamer-mediated control of self-cleaving ribozymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018009369A true MX2018009369A (es) | 2019-01-10 |
Family
ID=59500184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018009369A MX2018009369A (es) | 2016-02-02 | 2017-02-02 | Regulacion de expresion genica mediante control mediado por aptameros de ribozimas de autocorte. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US11512310B2 (es) |
| EP (1) | EP3411506B1 (es) |
| JP (1) | JP7222715B2 (es) |
| KR (1) | KR20180118650A (es) |
| CN (1) | CN109476697B (es) |
| AU (1) | AU2017213845B2 (es) |
| CA (1) | CA3048625A1 (es) |
| DK (1) | DK3411506T3 (es) |
| ES (1) | ES2954929T3 (es) |
| FI (1) | FI3411506T3 (es) |
| HR (1) | HRP20231119T1 (es) |
| HU (1) | HUE063465T2 (es) |
| IL (1) | IL260842B2 (es) |
| LT (1) | LT3411506T (es) |
| MX (1) | MX2018009369A (es) |
| MY (1) | MY198399A (es) |
| PH (1) | PH12018501651A1 (es) |
| PL (1) | PL3411506T3 (es) |
| PT (1) | PT3411506T (es) |
| RS (1) | RS64585B1 (es) |
| SG (1) | SG11201806589UA (es) |
| SI (1) | SI3411506T1 (es) |
| SM (1) | SMT202300302T1 (es) |
| WO (1) | WO2017136608A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019018240A2 (pt) * | 2017-03-02 | 2020-07-28 | MEIRAGTX, UK II Limited | regulação de expressão gene por clivagem de rnase p modulada por aptâmero |
| US20230265441A1 (en) | 2020-03-24 | 2023-08-24 | Meiragtx Uk Ii Limited | Aptamers That Bind Thiamine Analogs and Derivatives |
| WO2022150311A1 (en) * | 2021-01-05 | 2022-07-14 | University Of Washington | Modular kinetically-controlled functional rna constructs and related compositions, systems, and methods |
| WO2022150773A2 (en) * | 2021-01-11 | 2022-07-14 | The Regents Of The University Of California | Ribozyme-activated rna constructs and uses thereof |
| EP4448555A2 (en) | 2021-12-15 | 2024-10-23 | Meiragtx UK II Limited | Polycistronic expression of gut peptides |
| US20250101436A1 (en) * | 2021-12-15 | 2025-03-27 | Meiragtx Uk Ii Limited | Aptamers and small molecule ligands |
| CN114908095B (zh) * | 2022-06-09 | 2025-01-14 | 南开大学 | 一种基于核酶的靶向抑制靶标rna的方法和应用 |
| WO2024256870A1 (en) | 2023-06-14 | 2024-12-19 | Meiragtx Uk Ii Limited | Small molecule ligands and aptamers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050136035A1 (en) | 2003-06-03 | 2005-06-23 | Derek Ko | Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site |
| US20050158741A1 (en) | 2003-11-14 | 2005-07-21 | Children's Hospital | Self-cleaving ribozymes and uses thereof |
| WO2012065143A1 (en) * | 2010-11-12 | 2012-05-18 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| US9222093B2 (en) | 2011-06-30 | 2015-12-29 | The University Of Hong Kong | Two-way, portable riboswitch mediated gene expression control device |
-
2017
- 2017-02-02 ES ES17748194T patent/ES2954929T3/es active Active
- 2017-02-02 WO PCT/US2017/016303 patent/WO2017136608A2/en active Application Filing
- 2017-02-02 US US16/074,681 patent/US11512310B2/en active Active
- 2017-02-02 PT PT177481942T patent/PT3411506T/pt unknown
- 2017-02-02 RS RS20230822A patent/RS64585B1/sr unknown
- 2017-02-02 MY MYPI2018001382A patent/MY198399A/en unknown
- 2017-02-02 FI FIEP17748194.2T patent/FI3411506T3/fi active
- 2017-02-02 SG SG11201806589UA patent/SG11201806589UA/en unknown
- 2017-02-02 LT LTEPPCT/US2017/016303T patent/LT3411506T/lt unknown
- 2017-02-02 CA CA3048625A patent/CA3048625A1/en active Pending
- 2017-02-02 PL PL17748194.2T patent/PL3411506T3/pl unknown
- 2017-02-02 EP EP17748194.2A patent/EP3411506B1/en active Active
- 2017-02-02 DK DK17748194.2T patent/DK3411506T3/da active
- 2017-02-02 HU HUE17748194A patent/HUE063465T2/hu unknown
- 2017-02-02 KR KR1020187025104A patent/KR20180118650A/ko active Pending
- 2017-02-02 HR HRP20231119TT patent/HRP20231119T1/hr unknown
- 2017-02-02 CN CN201780021411.0A patent/CN109476697B/zh active Active
- 2017-02-02 AU AU2017213845A patent/AU2017213845B2/en active Active
- 2017-02-02 JP JP2018559687A patent/JP7222715B2/ja active Active
- 2017-02-02 MX MX2018009369A patent/MX2018009369A/es unknown
- 2017-02-02 SM SM20230302T patent/SMT202300302T1/it unknown
- 2017-02-02 SI SI201731412T patent/SI3411506T1/sl unknown
-
2018
- 2018-07-29 IL IL260842A patent/IL260842B2/en unknown
- 2018-08-02 PH PH12018501651A patent/PH12018501651A1/en unknown
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