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MX2018007319A - Imidazoquinolinas pegiladas como agonistas tlr7 y tlr8. - Google Patents

Imidazoquinolinas pegiladas como agonistas tlr7 y tlr8.

Info

Publication number
MX2018007319A
MX2018007319A MX2018007319A MX2018007319A MX2018007319A MX 2018007319 A MX2018007319 A MX 2018007319A MX 2018007319 A MX2018007319 A MX 2018007319A MX 2018007319 A MX2018007319 A MX 2018007319A MX 2018007319 A MX2018007319 A MX 2018007319A
Authority
MX
Mexico
Prior art keywords
imidazoquinolines
tlr7
pegylated
tlr8 agonists
tlr8
Prior art date
Application number
MX2018007319A
Other languages
English (en)
Inventor
G Bazin-Lee Helene
A Johnson David
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of MX2018007319A publication Critical patent/MX2018007319A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención proporciona nuevas imidazoquinolinas fosfolipidadas como agonistas de TLR7 y TLR8, composiciones farmacéuticas, usos terapéuticos y procedimientos para la preparación de las mismas.
MX2018007319A 2015-12-14 2016-12-12 Imidazoquinolinas pegiladas como agonistas tlr7 y tlr8. MX2018007319A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562266880P 2015-12-14 2015-12-14
PCT/EP2016/080645 WO2017102652A1 (en) 2015-12-14 2016-12-12 Pegylated imidazoquinolines as tlr7 and tlr8 agonists

Publications (1)

Publication Number Publication Date
MX2018007319A true MX2018007319A (es) 2018-09-06

Family

ID=57543038

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018007319A MX2018007319A (es) 2015-12-14 2016-12-12 Imidazoquinolinas pegiladas como agonistas tlr7 y tlr8.

Country Status (10)

Country Link
US (2) US10351582B2 (es)
EP (1) EP3390417B1 (es)
JP (1) JP2019500360A (es)
CN (1) CN108368140A (es)
BE (1) BE1024097B1 (es)
BR (1) BR112018011929A2 (es)
CA (1) CA3008055A1 (es)
ES (1) ES2848648T3 (es)
MX (1) MX2018007319A (es)
WO (1) WO2017102652A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018007319A (es) * 2015-12-14 2018-09-06 Glaxosmithkline Biologicals Sa Imidazoquinolinas pegiladas como agonistas tlr7 y tlr8.
JP2019505489A (ja) 2015-12-14 2019-02-28 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム イミダゾキノリン及びオキソアデニンのリン脂質化
ES2893166T3 (es) * 2016-09-07 2022-02-08 Glaxosmithkline Biologicals Sa Derivados de imidazoquinolina y su uso en terapia
EP3774806A1 (en) 2018-04-13 2021-02-17 GlaxoSmithKline Biologicals SA Tlr7 and / or tlr8 agonists
US20220096526A1 (en) * 2019-01-22 2022-03-31 Tufts Medical Center, Inc. Methods and compositions for the treatment and prevention of ocular diseases and conditions
KR102217403B1 (ko) 2019-01-30 2021-02-19 고려대학교 산학협력단 연속 결정학을 위한 메쉬 기반 결정 시료 홀더
JP7287708B2 (ja) * 2019-02-08 2023-06-06 プロジェニア インコーポレイテッド Ｔｏｌｌ－ｌｉｋｅ受容体７または８アゴニストとコレステロールの結合体およびその用途
MX2021012201A (es) 2019-04-05 2022-01-06 Sumitomo Pharma Co Ltd Adyuvante soluble en agua.
US20220241410A1 (en) * 2019-05-23 2022-08-04 The University Of Montana Vaccine adjuvants based on tlr receptor ligands
US11339159B2 (en) * 2019-07-17 2022-05-24 Pfizer Inc. Toll-like receptor agonists
CN112778372A (zh) * 2019-11-11 2021-05-11 苏州泽璟生物制药股份有限公司 咪唑并喹啉取代磷酸酯类激动剂及其制备方法和应用
US20230100429A1 (en) 2020-03-02 2023-03-30 Progeneer Inc. Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof
WO2022031011A1 (ko) 2020-08-04 2022-02-10 성균관대학교산학협력단 동력학적으로 작용하는 아주번트 앙상블
US20230346924A1 (en) 2020-08-04 2023-11-02 Progeneer Inc. Mrna vaccine comprising adjuvant capable of kinetic control
US20230277525A1 (en) 2020-08-04 2023-09-07 Progeneer Inc Conjugate of functional drug and toll-like receptor 7 or 8 agonist of which active site is temporarily inactivated and use thereof
WO2023249996A1 (en) * 2022-06-21 2023-12-28 Virovax Llc Vaccine adjuvants
CN116731015B (zh) * 2023-05-18 2024-09-27 深圳威科森生物医药科技有限公司 咪唑并喹啉化合物及其制备方法、应用和组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007113557A1 (en) * 2006-04-05 2007-10-11 Astrazeneca Ab Substituted quinazolines with anti-cancer activity
ES2667054T3 (es) * 2008-03-24 2018-05-09 Biontech Ag Nuevas imidazoquinolinas sustituidas
NO2341933T3 (es) 2008-10-24 2018-04-21
ES2617451T3 (es) 2010-08-17 2017-06-19 3M Innovative Properties Company Composiciones lipidadas de compuestos modificadores de la respuesta inmunitaria, formulaciones, y métodos
CN102372711B (zh) * 2010-08-18 2014-09-17 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
EP2674170B1 (en) * 2012-06-15 2014-11-19 Invivogen Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids
PT3134402T (pt) * 2014-04-22 2020-07-02 Hoffmann La Roche Compostos de 4-amino-imidazoquinolina
MX2018007319A (es) * 2015-12-14 2018-09-06 Glaxosmithkline Biologicals Sa Imidazoquinolinas pegiladas como agonistas tlr7 y tlr8.

Also Published As

Publication number Publication date
CA3008055A1 (en) 2017-06-22
EP3390417A1 (en) 2018-10-24
EP3390417B1 (en) 2020-08-26
US10351582B2 (en) 2019-07-16
ES2848648T3 (es) 2021-08-11
CN108368140A (zh) 2018-08-03
US20190375772A1 (en) 2019-12-12
US20180362560A1 (en) 2018-12-20
US10882876B2 (en) 2021-01-05
WO2017102652A1 (en) 2017-06-22
BR112018011929A2 (pt) 2018-11-27
BE1024097A1 (fr) 2017-11-14
JP2019500360A (ja) 2019-01-10
BE1024097B1 (fr) 2017-11-16

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