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MX2017011418A - Metodos para manipular geneticamente celula t alogenica para aumentar su persistencia y/o injerto en pacientes. - Google Patents

Metodos para manipular geneticamente celula t alogenica para aumentar su persistencia y/o injerto en pacientes.

Info

Publication number
MX2017011418A
MX2017011418A MX2017011418A MX2017011418A MX2017011418A MX 2017011418 A MX2017011418 A MX 2017011418A MX 2017011418 A MX2017011418 A MX 2017011418A MX 2017011418 A MX2017011418 A MX 2017011418A MX 2017011418 A MX2017011418 A MX 2017011418A
Authority
MX
Mexico
Prior art keywords
engraftment
persistence
methods
patients
cell
Prior art date
Application number
MX2017011418A
Other languages
English (en)
Inventor
Duchateau Philippe
Pierre Cabaniols Jean
Poirot Laurent
Valton Julien
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Publication of MX2017011418A publication Critical patent/MX2017011418A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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Abstract

La presente invención se refiere a métodos para el desarrollo de células inmunitarias genéticamente manipuladas, tales como células T para inmunoterapia que tienen un mayor potencial de persistencia y/o injerto en el organismo hospedero. En particular, este método implica una inactivación de al menos un gen implicado en el auto /no auto-reconocimiento, en combinación con un paso de contacto con al menos un polipéptido inmunosupresor no endógeno. La invención permite la posibilidad de una inmunoterapia adoptiva estándar y asequible, por lo que se reduce el riesgo de GvH.
MX2017011418A 2015-03-11 2016-03-11 Metodos para manipular geneticamente celula t alogenica para aumentar su persistencia y/o injerto en pacientes. MX2017011418A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201570138 2015-03-11
PCT/EP2016/055332 WO2016142532A1 (en) 2015-03-11 2016-03-11 Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients

Publications (1)

Publication Number Publication Date
MX2017011418A true MX2017011418A (es) 2017-12-14

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MX2017011418A MX2017011418A (es) 2015-03-11 2016-03-11 Metodos para manipular geneticamente celula t alogenica para aumentar su persistencia y/o injerto en pacientes.

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Country Link
US (1) US11186824B2 (es)
EP (1) EP3268388A1 (es)
JP (1) JP2018509148A (es)
KR (1) KR20170137079A (es)
CN (1) CN107683333A (es)
AU (1) AU2016231061B2 (es)
BR (1) BR112017018224A2 (es)
CA (1) CA2978840A1 (es)
IL (1) IL253879A0 (es)
MX (1) MX2017011418A (es)
RU (1) RU2017134441A (es)
WO (1) WO2016142532A1 (es)

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DK3693384T5 (da) * 2014-03-11 2024-08-26 Cellectis Fremgangsmåde til at generere T-celler med kompatibilitet for allogen transplantation
AU2016296741A1 (en) 2015-07-21 2018-02-22 The Children's Medical Center Corporation PD-L1 expressing hematopoietic stem cells and uses
AU2016362129A1 (en) 2015-12-04 2018-06-14 Intellia Therapeutics, Inc. Compositions and methods for immunooncology
AU2017330423A1 (en) * 2016-09-23 2019-04-11 University Of Southern California Chimeric antigen receptors and compositions and methods of use thereof
WO2018115189A1 (en) 2016-12-21 2018-06-28 Cellectis Stably enginereed proteasome inhibitor resistant immune cells for immunotherapy
MX2019008413A (es) * 2017-01-13 2019-09-13 Univ California Celulas pluripotentes inmunodiseñadas.
JP2020513832A (ja) 2017-03-22 2020-05-21 ノバルティス アーゲー 免疫腫瘍学のための組成物および方法
CA3057265A1 (en) * 2017-04-19 2018-10-25 Allogene Therapeutics, Inc. Improved t cell compositions and methods
CN107177632B (zh) * 2017-05-27 2020-02-07 上海优卡迪生物医药科技有限公司 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用
WO2019060708A1 (en) 2017-09-22 2019-03-28 The Children's Medical Center Corporation TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS
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