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MX2017006437A - Compuestos espiroisoquinolin-1,4'-piperidinicos con actividad multimodal contra el dolor. - Google Patents

Compuestos espiroisoquinolin-1,4'-piperidinicos con actividad multimodal contra el dolor.

Info

Publication number
MX2017006437A
MX2017006437A MX2017006437A MX2017006437A MX2017006437A MX 2017006437 A MX2017006437 A MX 2017006437A MX 2017006437 A MX2017006437 A MX 2017006437A MX 2017006437 A MX2017006437 A MX 2017006437A MX 2017006437 A MX2017006437 A MX 2017006437A
Authority
MX
Mexico
Prior art keywords
isoquinoline
spiro
piperidine compounds
activity against
against pain
Prior art date
Application number
MX2017006437A
Other languages
English (en)
Inventor
Almansa-Rosales Carmen
GARCIA-LOPEZ Mónica
María CAAMANO-MOURE Ana
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of MX2017006437A publication Critical patent/MX2017006437A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos espiroisoquinolin-1,4'-piperidínicos que presentan una actividad farmacológica dual hacia tanto el receptor sigma (s) como el receptor opioide µ, a procesos para preparar tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia, en particular para el tratamiento del dolor.
MX2017006437A 2014-11-21 2015-11-20 Compuestos espiroisoquinolin-1,4'-piperidinicos con actividad multimodal contra el dolor. MX2017006437A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14382465 2014-11-21
PCT/EP2015/002332 WO2016078770A1 (en) 2014-11-21 2015-11-20 Spiro-isoquinoline-1,4'-piperidine compounds having multimodal activity against pain

Publications (1)

Publication Number Publication Date
MX2017006437A true MX2017006437A (es) 2017-08-08

Family

ID=51932303

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017006437A MX2017006437A (es) 2014-11-21 2015-11-20 Compuestos espiroisoquinolin-1,4'-piperidinicos con actividad multimodal contra el dolor.

Country Status (10)

Country Link
US (1) US10407428B2 (es)
EP (1) EP3221314B1 (es)
JP (1) JP2017535545A (es)
CN (1) CN107001369A (es)
AR (1) AR102731A1 (es)
CA (1) CA2967097A1 (es)
ES (1) ES2748694T3 (es)
MX (1) MX2017006437A (es)
TW (1) TW201632522A (es)
WO (1) WO2016078770A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017535566A (ja) * 2014-11-21 2017-11-30 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ 疼痛に対する多様な活性を有する１，９−ジアザスピロウンデカン化合物
WO2018153545A1 (en) * 2017-02-27 2018-08-30 Laboratorios Del Dr. Esteve, S.A. Piperidine methanone derivatives having multimodal activity against pain
WO2019180189A1 (en) 2018-03-23 2019-09-26 Esteve Pharmaceuticals, S.A. Aminopropoxyphenyl and benzyl 3,4-dihydro-2h-spiro[isoquinoline-1,4'-piperidin]-1'-yl derivatives having multimodal activity against pain
WO2019206800A1 (en) * 2018-04-24 2019-10-31 Phenex Discovery Verwaltungs-GmbH Spirocyclic compounds as modulators of indoleamine 2,3-dioxygenase
US11618746B2 (en) 2018-12-17 2023-04-04 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
EP3858438A1 (en) 2020-02-03 2021-08-04 Esteve Pharmaceuticals, S.A. 3,4-dihydro-2h-spiro[isoquinoline-1,4'-piperidin]amide derivatives having multimodal activity against pain
KR20230057386A (ko) 2020-08-26 2023-04-28 버텍스 파마슈티칼스 인코포레이티드 Apol1 억제제 및 사용 방법
AU2023218940A1 (en) * 2022-02-08 2024-08-22 Vertex Pharmaceuticals Incorporated Spiro piperidine derivatives as inhibitors of apol1 and methods of using same
WO2023190663A1 (ja) * 2022-03-30 2023-10-05 参天製薬株式会社 高純度化合物の製造方法および精製方法
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3301857A (en) * 1963-08-26 1967-01-31 Hoffmann La Roche Spiro
EP0702681A1 (en) * 1993-06-07 1996-03-27 Merck & Co. Inc. Spiro-substituted azacycles as neurokinin antagonists
AU2223495A (en) * 1994-04-15 1995-11-10 Yamanouchi Pharmaceutical Co., Ltd. Spiro compound and medicinal composition thereof
US6013652A (en) 1997-12-04 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
PE20040749A1 (es) * 2002-06-27 2004-10-23 Schering Corp Piperidinas espirosustituidas como antagonistas selectivos del receptor de la hormona concentradora de melanina
WO2005016913A1 (en) 2003-08-19 2005-02-24 Pfizer Japan, Inc. Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders
GB0504556D0 (en) * 2005-03-04 2005-04-13 Pfizer Ltd Novel pharmaceuticals
US8193208B2 (en) * 2005-09-09 2012-06-05 Purdue Pharma L.P. Fused and spirocycle compounds and the use thereof
EP1847542A1 (en) * 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor
EP1982987A1 (en) * 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Spiro-pyrano-pyrazole derivatives
US8393093B2 (en) * 2009-07-07 2013-03-12 Susan K. Cleveland Method and tool for forming picots

Also Published As

Publication number Publication date
WO2016078770A1 (en) 2016-05-26
TW201632522A (zh) 2016-09-16
AR102731A1 (es) 2017-03-22
CN107001369A (zh) 2017-08-01
EP3221314B1 (en) 2019-07-03
US20180111935A1 (en) 2018-04-26
US10407428B2 (en) 2019-09-10
ES2748694T3 (es) 2020-03-17
CA2967097A1 (en) 2016-05-26
JP2017535545A (ja) 2017-11-30
EP3221314A1 (en) 2017-09-27

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