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MX2017006412A - Forma cristalina de sulfato acido de (s)-n-(5-((r)-2-(2,5-difluoro fenil)-pirrolidin-1-il)-pirazolo[1,5-a]-pirimidin-3-il)-3-hidroxi pirrolidina-1-carboxamida. - Google Patents

Forma cristalina de sulfato acido de (s)-n-(5-((r)-2-(2,5-difluoro fenil)-pirrolidin-1-il)-pirazolo[1,5-a]-pirimidin-3-il)-3-hidroxi pirrolidina-1-carboxamida.

Info

Publication number
MX2017006412A
MX2017006412A MX2017006412A MX2017006412A MX2017006412A MX 2017006412 A MX2017006412 A MX 2017006412A MX 2017006412 A MX2017006412 A MX 2017006412A MX 2017006412 A MX2017006412 A MX 2017006412A MX 2017006412 A MX2017006412 A MX 2017006412A
Authority
MX
Mexico
Prior art keywords
crystalline form
hydroxypyrrolidine
pyrazolo
difluorophenyl
pyrimidin
Prior art date
Application number
MX2017006412A
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English (en)
Inventor
B Arrigo Alisha
Shah Khalid
Juengst Derrick
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Array Biopharma Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54848892&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017006412(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of MX2017006412A publication Critical patent/MX2017006412A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • G01N2333/91205—Phosphotransferases in general
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Abstract

La presente invención se refiere a una novedosa forma cristalina de (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-iI)-pirazolo[1 ,5-a]-pirimidin-3-iI)-3-hidroxipirrolidina-1-carboxamida, a composiciones farmacéuticas que contienen dicha forma cristalina, y al uso de la forma cristalina en el tratamiento del dolor, cáncer, inflamación, enfermedad neurodegenerativa o infección por Trypanosoma cruzi. En algunas modalidades, la novedosa forma cristalina comprende una forma polimórfica estable de sulfato ácido de (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-iI)-pira zolo[1,5-a]-pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida. La presente invención se refiere además a un proceso para la preparación de la novedosa forma cristalina.
MX2017006412A 2014-11-16 2015-11-16 Forma cristalina de sulfato acido de (s)-n-(5-((r)-2-(2,5-difluoro fenil)-pirrolidin-1-il)-pirazolo[1,5-a]-pirimidin-3-il)-3-hidroxi pirrolidina-1-carboxamida. MX2017006412A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462080374P 2014-11-16 2014-11-16
US201562169545P 2015-06-01 2015-06-01
PCT/US2015/060953 WO2016077841A1 (en) 2014-11-16 2015-11-16 Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate

Publications (1)

Publication Number Publication Date
MX2017006412A true MX2017006412A (es) 2017-09-12

Family

ID=54848892

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Application Number Title Priority Date Filing Date
MX2017006412A MX2017006412A (es) 2014-11-16 2015-11-16 Forma cristalina de sulfato acido de (s)-n-(5-((r)-2-(2,5-difluoro fenil)-pirrolidin-1-il)-pirazolo[1,5-a]-pirimidin-3-il)-3-hidroxi pirrolidina-1-carboxamida.
MX2020011079A MX2020011079A (es) 2014-11-16 2017-05-16 Forma cristalina de sulfato acido de (s)-n-(5-((r)-2-(2,5-difluoro fenil)-pirrolidin-1-il)-pirazolo[1,5-a]-pirimidin-3-il)-3-hidroxi pirrolidina-1-carboxamida.

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MX2020011079A MX2020011079A (es) 2014-11-16 2017-05-16 Forma cristalina de sulfato acido de (s)-n-(5-((r)-2-(2,5-difluoro fenil)-pirrolidin-1-il)-pirazolo[1,5-a]-pirimidin-3-il)-3-hidroxi pirrolidina-1-carboxamida.

Country Status (30)

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US (5) US10799505B2 (es)
EP (2) EP3699181B1 (es)
JP (2) JP6914834B2 (es)
KR (1) KR102649887B1 (es)
CN (2) CN113354649A (es)
AU (1) AU2015346046B2 (es)
BR (1) BR112017010141A2 (es)
CA (1) CA2967951C (es)
CL (1) CL2017001249A1 (es)
CO (1) CO2017005483A2 (es)
CR (1) CR20170263A (es)
DK (1) DK3699181T3 (es)
ES (1) ES2941630T3 (es)
FI (1) FI3699181T3 (es)
HK (1) HK1244483A1 (es)
HR (1) HRP20230271T1 (es)
HU (1) HUE061448T2 (es)
IL (2) IL290905B2 (es)
LT (1) LT3699181T (es)
MX (2) MX2017006412A (es)
PH (2) PH12017500900A1 (es)
PL (1) PL3699181T3 (es)
PT (1) PT3699181T (es)
RS (1) RS64122B1 (es)
SG (1) SG11201703962XA (es)
SI (1) SI3699181T1 (es)
TW (2) TWI767858B (es)
UA (1) UA123044C2 (es)
WO (1) WO2016077841A1 (es)
ZA (1) ZA201703501B (es)

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