[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

MX2017005659A - Nuevos compuestos de metil-piperidina utiles para inhibir la sintasa-1 de prostaglandina microsomal e2. - Google Patents

Nuevos compuestos de metil-piperidina utiles para inhibir la sintasa-1 de prostaglandina microsomal e2.

Info

Publication number
MX2017005659A
MX2017005659A MX2017005659A MX2017005659A MX2017005659A MX 2017005659 A MX2017005659 A MX 2017005659A MX 2017005659 A MX2017005659 A MX 2017005659A MX 2017005659 A MX2017005659 A MX 2017005659A MX 2017005659 A MX2017005659 A MX 2017005659A
Authority
MX
Mexico
Prior art keywords
synthase
compounds useful
piperidine compounds
microsomal prostaglandin
novel methyl
Prior art date
Application number
MX2017005659A
Other languages
English (en)
Inventor
Joseph Fisher Matthew
Lee Kuklish Steven
Allen Schiffler Matthew
Schulenburg York Jeremy
Rudolph Manninen Peter
M Warshawsky Alan
Marie Partridge Katherine
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54478248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017005659(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2017005659A publication Critical patent/MX2017005659A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (1), o una sal farmacéuticamente aceptable del mismo, donde R, R1 y G son como se describen en la presente; métodos para preparar los compuestos; y uso de los compuestos para tratar dolor y/o inflamación asociada con artritis u osteoartritis. (ver Fórmula).
MX2017005659A 2014-10-29 2015-10-22 Nuevos compuestos de metil-piperidina utiles para inhibir la sintasa-1 de prostaglandina microsomal e2. MX2017005659A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462072196P 2014-10-29 2014-10-29
PCT/US2015/056960 WO2016069376A1 (en) 2014-10-29 2015-10-22 Novel methyl-piperidine compounds useful for inhibiting microsomal prostaglandin e2 synthase-1

Publications (1)

Publication Number Publication Date
MX2017005659A true MX2017005659A (es) 2017-06-26

Family

ID=54478248

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005659A MX2017005659A (es) 2014-10-29 2015-10-22 Nuevos compuestos de metil-piperidina utiles para inhibir la sintasa-1 de prostaglandina microsomal e2.

Country Status (26)

Country Link
US (2) US9962375B2 (es)
EP (1) EP3230278B1 (es)
JP (1) JP6393830B2 (es)
KR (1) KR101898829B1 (es)
CN (1) CN107074829B (es)
AR (1) AR102362A1 (es)
AU (1) AU2015339644B2 (es)
CA (1) CA2963321C (es)
CL (1) CL2017001017A1 (es)
CY (1) CY1122534T1 (es)
DK (1) DK3230278T3 (es)
EA (1) EA032428B1 (es)
ES (1) ES2773439T3 (es)
HR (1) HRP20200216T1 (es)
HU (1) HUE047895T2 (es)
JO (1) JO3581B1 (es)
LT (1) LT3230278T (es)
MX (1) MX2017005659A (es)
NZ (1) NZ730724A (es)
PL (1) PL3230278T3 (es)
PT (1) PT3230278T (es)
RS (1) RS59783B1 (es)
SI (1) SI3230278T1 (es)
TW (1) TWI605039B (es)
WO (1) WO2016069376A1 (es)
ZA (1) ZA201702198B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR102361A1 (es) 2014-10-29 2017-02-22 Lilly Co Eli Compuestos de metil-quinolina útiles para inhibir la sintasa-1 de prostaglandina microsomal e2
JP7305654B2 (ja) * 2018-01-09 2023-07-10 ブリガム・ヤング・ユニバーシティ ウォゴニンで疼痛を治療するための組成物および方法
CN108558806B (zh) * 2018-05-31 2020-04-17 南京药石科技股份有限公司 一种5-氧代-四氢吡喃-3-羧酸酯的关键中间体及其制备方法
WO2020061475A2 (en) * 2018-09-21 2020-03-26 The Johns Hopkins University Compositions and methods for treating metabolic disorders
AU2020301161B2 (en) 2019-06-25 2023-10-26 Gilead Sciences, Inc. FLT3L-Fc fusion proteins and methods of use
CN114555123B (zh) 2019-10-18 2024-04-02 四十七公司 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法
MX2022005123A (es) 2019-10-31 2022-05-30 Forty Seven Inc Tratamiento basado en anti-cd47 y anti-cd20 para cancer hematologico.
TWI778443B (zh) 2019-11-12 2022-09-21 美商基利科學股份有限公司 Mcl1抑制劑
CR20220303A (es) 2019-12-24 2022-09-02 Gilead Sciences Inc Compuestos moduladores de la diacilglicerol quinasa
CN117964757A (zh) 2020-02-14 2024-05-03 吉利德科学公司 与ccr8结合的抗体和融合蛋白及其用途
IL297327A (en) 2020-05-01 2022-12-01 Gilead Sciences Inc 4,2-deoxypyrimidine compounds that inhibit cd73
WO2022039563A1 (en) * 2020-08-21 2022-02-24 Kanaph Therapeutics Inc. Novel compounds having inhibitory activity on prostaglandin e2 receptor and uses thereof
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
WO2022245671A1 (en) 2021-05-18 2022-11-24 Gilead Sciences, Inc. Methods of using flt3l-fc fusion proteins
AU2022297373A1 (en) 2021-06-23 2024-01-04 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
AU2022299051A1 (en) 2021-06-23 2023-12-07 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
JP2024522594A (ja) 2021-06-23 2024-06-21 ギリアード サイエンシーズ, インコーポレイテッド ジアシルグリセロールキナーゼ調節化合物
WO2022271659A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3234909A1 (en) 2021-10-28 2023-05-04 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
KR20240097895A (ko) 2021-10-29 2024-06-27 길리애드 사이언시즈, 인코포레이티드 Cd73 화합물
EP4452414A2 (en) 2021-12-22 2024-10-30 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
CA3237577A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
IL313831A (en) 2021-12-28 2024-08-01 Nippon Shinyaku Co Ltd Indazole compound and pharmaceutical preparation
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
WO2023178181A1 (en) 2022-03-17 2023-09-21 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
US20230355796A1 (en) 2022-03-24 2023-11-09 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
TW202345901A (zh) 2022-04-05 2023-12-01 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
WO2023205719A1 (en) 2022-04-21 2023-10-26 Gilead Sciences, Inc. Kras g12d modulating compounds
US20240116928A1 (en) 2022-07-01 2024-04-11 Gilead Sciences, Inc. Cd73 compounds
US20240091351A1 (en) 2022-09-21 2024-03-21 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY
WO2024137852A1 (en) 2022-12-22 2024-06-27 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2024215754A1 (en) 2023-04-11 2024-10-17 Gilead Sciences, Inc. Kras modulating compounds
WO2024220917A1 (en) 2023-04-21 2024-10-24 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355010B1 (en) * 1999-03-31 2002-03-12 Coaxia, Inc. Intravascular spinal perfusion and cooling for use during aortic surgery
ATE556067T1 (de) * 2003-05-20 2012-05-15 Ajinomoto Kk Modulatoren des vanilloid rezeptors
US20050239921A1 (en) * 2004-04-27 2005-10-27 Birmingham John N Preparation of organic additive-treated, pyrogenic silica-encapsulated titanium dioxide particles
UY32470A (es) * 2009-03-05 2010-10-29 Boehringer Ingelheim Int Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones
WO2011023812A1 (en) 2009-08-27 2011-03-03 Novasaid Ab Microsomal prostaglandin e synthase-1 (mpges1) inhibitors
WO2011048004A1 (en) * 2009-10-23 2011-04-28 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin e2 synthase-1
WO2013146970A1 (ja) * 2012-03-29 2013-10-03 第一三共株式会社 新規キノリン誘導体
CA2916101A1 (en) * 2013-06-20 2014-12-24 Novasaid Ab Piperidinyl benzoimidazole derivatives as mpge-1 inhibitors
AR102361A1 (es) 2014-10-29 2017-02-22 Lilly Co Eli Compuestos de metil-quinolina útiles para inhibir la sintasa-1 de prostaglandina microsomal e2

Also Published As

Publication number Publication date
PL3230278T3 (pl) 2020-06-01
RS59783B1 (sr) 2020-02-28
NZ730724A (en) 2018-09-28
SI3230278T1 (sl) 2020-02-28
DK3230278T3 (da) 2020-01-20
EA032428B1 (ru) 2019-05-31
ES2773439T3 (es) 2020-07-13
EP3230278B1 (en) 2019-12-11
BR112017007011A2 (pt) 2017-12-26
EA201790766A1 (ru) 2017-12-29
HRP20200216T1 (hr) 2020-05-15
PT3230278T (pt) 2020-02-20
US20170326128A1 (en) 2017-11-16
JP6393830B2 (ja) 2018-09-19
AU2015339644A1 (en) 2017-04-20
JP2017537073A (ja) 2017-12-14
ZA201702198B (en) 2018-12-19
CN107074829A (zh) 2017-08-18
WO2016069376A1 (en) 2016-05-06
US20180250282A1 (en) 2018-09-06
AR102362A1 (es) 2017-02-22
US9962375B2 (en) 2018-05-08
CA2963321C (en) 2020-01-14
JO3581B1 (ar) 2020-07-05
CA2963321A1 (en) 2016-05-06
EP3230278A1 (en) 2017-10-18
HUE047895T2 (hu) 2020-05-28
CN107074829B (zh) 2020-11-13
CL2017001017A1 (es) 2017-12-11
TWI605039B (zh) 2017-11-11
KR101898829B1 (ko) 2018-09-13
KR20170055025A (ko) 2017-05-18
CY1122534T1 (el) 2021-01-27
LT3230278T (lt) 2020-03-10
TW201627285A (zh) 2016-08-01
AU2015339644B2 (en) 2018-03-29

Similar Documents

Publication Publication Date Title
NZ730724A (en) Novel methyl-piperidine compounds useful for inhibiting microsomal prostaglandin e2 synthase-1
NZ730730A (en) Novel carboxylic acid compounds useful for inhibiting microsomal prostaglandin e2 synthase-1
PH12018502102A1 (en) Pyrrolotriazine compounds as tam inhibitors
PH12016502382A1 (en) Substituted indazole compounds as irak4 inhibitors
MX2017006266A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas al receptor de interleucina 1(irak) y sus usos.
SG10201811384TA (en) Mnk inhibitors and methods related thereto
JO3466B1 (ar) مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
MX2020011449A (es) Oxiesteroles y metodos de uso de los mismos.
MY197698A (en) Oxysterols and methods of use thereof
AU2018253590A1 (en) Imidazopyridazine compounds
NZ746825A (en) Oxysterols and methods of use thereof
MX2020006237A (es) Compuestos para el tratamiento de enfermedades relacionadas con la expresion de dux4.
MX2016005128A (es) Derivados de 5,6,7,8-tetahidro-5,8-metanocinolina como moduladores del receptor huerfano y relacionado con acido retinoico (rorc) para el tratamiento de enfermedades autoinmunes.
EA201792425A1 (ru) Трициклические соединения и их применение в качестве ингибиторов фосфодиэстераз
MX2016002718A (es) Derivados de ceto-imidazopiridina como moduladores del receptor huerfano relacionado con receptor retinoide (porc).
PH12014501712B1 (en) Novel morpholinyl derivatives useful as mogat-2-inhibitors
PH12016501997B1 (en) Cycloalkyl-linked diheterocycle derivatives
MY184366A (en) Pyrazines modulators of gpr6
PH12019500370A1 (en) Triazolopyrazinone derivative useful as a human pde1 inhibitor
AU2016330503A8 (en) Therapeutic compounds and methods of use thereof
MX2018015269A (es) Derivados de tailanstatina a, metodos de tratamiento y metodos de sintesis de los mismos.
PH12017500492A1 (en) Crystalline bace inhibitors

Legal Events

Date Code Title Description
FG Grant or registration