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MX2013014109A - Proteina de fusion que comprende el mutante crm197 no toxico de toxina de difteria. - Google Patents

Proteina de fusion que comprende el mutante crm197 no toxico de toxina de difteria.

Info

Publication number
MX2013014109A
MX2013014109A MX2013014109A MX2013014109A MX2013014109A MX 2013014109 A MX2013014109 A MX 2013014109A MX 2013014109 A MX2013014109 A MX 2013014109A MX 2013014109 A MX2013014109 A MX 2013014109A MX 2013014109 A MX2013014109 A MX 2013014109A
Authority
MX
Mexico
Prior art keywords
fragment
protein
fusion protein
crm197
diphtheria toxin
Prior art date
Application number
MX2013014109A
Other languages
English (en)
Other versions
MX346245B (es
Inventor
Ying Gu
Shaowei Li
Cuiling Song
Chunyan Yang
Wenxin Luo
Ningshao Xia
Original Assignee
Univ Xiamen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Xiamen filed Critical Univ Xiamen
Publication of MX2013014109A publication Critical patent/MX2013014109A/es
Publication of MX346245B publication Critical patent/MX346245B/es

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    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • A61K2039/6031—Proteins
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Abstract

Se proporciona en la presente invención un mutante CRM197 no tóxico de la toxina de difteria o uno de sus fragmentos como un adyuvante en una proteína de fusión y su uso para mejorar la inmunogenicidad de una proteína de fusión fusionada con la misma, por ejemplo, una proteína cápside HEV, o una proteína M2 del virus de influenza o uno de sus fragmentos inmunogénicos. También se proporciona un método para mejorar la inmunogenicidad de una proteína de fusión, que comprende la expresión de la fusión de CRM197 o uno de sus fragmentos con la proteína objetivo para formar una proteína de fusión. Además se provee una proteína de fusión que comprende CRM197 o uno de sus fragmentos y una proteína objetivo, CRM197 o uno de sus fragmentos mejoran la inmunogenicidad de la proteína objetivo. La presente invención también proporciona un ácido nucleico aislado que codifica la proteína de fusión, un constructo y un vector que comprenden el ácido nucleico, y una cálula hospedera que comprende el ácido nucleico.
MX2013014109A 2011-06-01 2012-06-01 Proteina de fusion que comprende el mutante crm197 no toxico de toxina de difteria. MX346245B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201110145419 2011-06-01
PCT/CN2012/076378 WO2012163289A1 (zh) 2011-06-01 2012-06-01 包含白喉毒素无毒突变体crm197或其片段的融合蛋白

Publications (2)

Publication Number Publication Date
MX2013014109A true MX2013014109A (es) 2014-06-05
MX346245B MX346245B (es) 2017-03-13

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MX2013014109A MX346245B (es) 2011-06-01 2012-06-01 Proteina de fusion que comprende el mutante crm197 no toxico de toxina de difteria.

Country Status (10)

Country Link
US (3) US9512185B2 (es)
EP (1) EP2716661B1 (es)
JP (1) JP6048845B2 (es)
KR (2) KR101839496B1 (es)
CN (2) CN102807621B (es)
AU (1) AU2012265320B2 (es)
BR (1) BR112013030963B1 (es)
MX (1) MX346245B (es)
WO (1) WO2012163289A1 (es)
ZA (1) ZA201400047B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2716661B1 (en) 2011-06-01 2018-03-07 Xiamen University Fusion protein comprising diphtheria toxin non-toxic mutant crm197 or fragment thereof
ES2924914T3 (es) * 2013-03-15 2022-10-11 Glaxosmithkline Biologicals Sa Vacuna contra rinovirus humano
CN104140972B (zh) * 2013-05-07 2018-01-23 上海惠盾生物技术有限公司 白喉毒素突变体crm197的制备方法
CN105705522B (zh) * 2013-05-14 2020-09-15 上海亨臻实业有限公司 针对低免疫原性蛋白的表位疫苗及其制法和用途
CN103540616B (zh) * 2013-10-23 2015-08-12 中国人民解放军南京军区福州总医院 表达白喉毒素a片段的慢病毒载体系统及其制备与应用
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BR112013030963A2 (pt) 2016-09-06
JP6048845B2 (ja) 2016-12-21
AU2012265320B2 (en) 2016-11-03
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US9512185B2 (en) 2016-12-06
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