[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

MX2011013879A - 4-hidroxipirimidina-5-carboxamidas sustituidas. - Google Patents

4-hidroxipirimidina-5-carboxamidas sustituidas.

Info

Publication number
MX2011013879A
MX2011013879A MX2011013879A MX2011013879A MX2011013879A MX 2011013879 A MX2011013879 A MX 2011013879A MX 2011013879 A MX2011013879 A MX 2011013879A MX 2011013879 A MX2011013879 A MX 2011013879A MX 2011013879 A MX2011013879 A MX 2011013879A
Authority
MX
Mexico
Prior art keywords
hydroxypyrimidine
substituted
carboxamides
conditions
relates
Prior art date
Application number
MX2011013879A
Other languages
English (en)
Inventor
Matthew J Clements
John S Debenham
Jeffrey J Hale
Christina Madsen-Duggan
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2011013879A publication Critical patent/MX2011013879A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a 4-hidroxipirimidina-5-carboxami das sustituidas útiles como inhibidores de HIF prolil hidroxilasa para tratar la anemia y condiciones similares.
MX2011013879A 2009-06-30 2010-06-21 4-hidroxipirimidina-5-carboxamidas sustituidas. MX2011013879A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22183809P 2009-06-30 2009-06-30
US23746709P 2009-08-27 2009-08-27
PCT/US2010/039292 WO2011002624A1 (en) 2009-06-30 2010-06-21 Substituted 4-hydroxypyrimidine-5-carboxamides

Publications (1)

Publication Number Publication Date
MX2011013879A true MX2011013879A (es) 2012-02-01

Family

ID=43411373

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011013879A MX2011013879A (es) 2009-06-30 2010-06-21 4-hidroxipirimidina-5-carboxamidas sustituidas.

Country Status (8)

Country Link
US (1) US8372857B2 (es)
EP (1) EP2448584B1 (es)
JP (1) JP2012532128A (es)
CN (1) CN102802628A (es)
AU (1) AU2010266559A1 (es)
CA (1) CA2766139A1 (es)
MX (1) MX2011013879A (es)
WO (1) WO2011002624A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201400458A (zh) 2012-03-30 2014-01-01 Daiichi Sankyo Co Ltd （２－雜芳基胺基）琥珀酸衍生物
AU2016205030B2 (en) 2015-01-09 2021-04-01 The Board Of Trustees Of The University Of Illinois Restoring physiology in iron-deficient organisms using small molecules
WO2020156571A1 (zh) * 2019-02-02 2020-08-06 杭州华东医药集团新药研究院有限公司 一种哒嗪衍生物及其制备方法和医药用途
WO2024222893A1 (en) * 2023-04-28 2024-10-31 Insilico Medicine Ip Limited Crystalline prolyl hydroxylase domain-containing protein (phd) inhibitor and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4464280B2 (ja) * 2002-12-06 2010-05-19 興和株式会社 エリスロポエチン産生促進剤
WO2007038571A2 (en) 2005-09-26 2007-04-05 Smithkline Beecham Corporation Prolyl hydroxylase antagonists
US7588924B2 (en) * 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
TW200845994A (en) * 2007-01-12 2008-12-01 Smithkline Beecham Corp N-substituted glycine derivatives: prolyl hydroxylase inhibitors
US8409473B2 (en) 2007-01-30 2013-04-02 Evident Technologies, Inc. Group II alloyed I-III-VI semiconductor nanocrystal compositions and methods of making same
WO2009117269A1 (en) * 2008-03-18 2009-09-24 Merck & Co., Inc. Substituted 4-hydroxypyrimidine-5-carboxamides
JP2012532127A (ja) * 2009-06-30 2012-12-13 メルク・シャープ・エンド・ドーム・コーポレイション 置換４−ヒドロキシピリミジン−５−カルボキサミド

Also Published As

Publication number Publication date
CN102802628A (zh) 2012-11-28
EP2448584A1 (en) 2012-05-09
WO2011002624A1 (en) 2011-01-06
US8372857B2 (en) 2013-02-12
EP2448584A4 (en) 2012-12-19
JP2012532128A (ja) 2012-12-13
AU2010266559A1 (en) 2011-12-15
US20120142694A1 (en) 2012-06-07
EP2448584B1 (en) 2014-12-31
CA2766139A1 (en) 2011-01-06

Similar Documents

Publication Publication Date Title
MX2010010209A (es) 4-hidroxipirimidina-5-carboxamidas sustituidas.
JO2788B1 (en) Amido phenoxyendazole compounds beneficial as C-MET inhibitors
ZA201401310B (en) Polymorphic forms of compounds as prolyl hydroxylase inhibitor,and uses thereof
HK1190334A1 (en) Prolyl hydroxylase inhibitors
AU2012289429A8 (en) Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof
MX2010009765A (es) Moleculas pequeñas que contienen boro como agentes anti-inflamatorios.
HRP20141038T1 (en) Benzoimidazoles as prolyl hydroxylase inhibitors
IL212762A0 (en) Thiochromene derivatives as hif hydroxylase inhibitors
MX2011014019A (es) Derivados de diazahomoadamantano y sus metodos de uso.
GB2471806A (en) Compositions and methods for treating viral infections
ME01858B (me) Jedinjenje triazolopiridina i njegovo dejstvo kao inhibitora prolil hidroksilaze i induktora proizvodnje eritropoetina
MY167126A (en) Novel modified release dosage forms of xanthine oxidoreductase inhibitor or xanthine oxidase inhibitors
WO2008130600A3 (en) Quinolones and azaquinolones that inhibit prolyl hydroxylase
EP2326178A4 (en) INHIBITORS OF PROLYL-HYDROXYLASE
MX2011013878A (es) 4-hidroxipirimidina-5-carboxamidas sustituidas.
EP2273879A4 (en) PROLYLHYDROXYLASEHEMMER
EP2326179A4 (en) PROLYLHYDROXYLASEHEMMER
MY161868A (en) Anti-bv8 antibodies and uses thereof
EP2306828A4 (en) INHIBITORS OF PROLYL HYDROXYLASES
WO2009137291A3 (en) Spiroazaindoles
MX2011013879A (es) 4-hidroxipirimidina-5-carboxamidas sustituidas.
UA99332C2 (en) Herbicidal combinations having diflufenican and pinoxaden and use thereof
TN2011000013A1 (en) Amidophenoxyindazoles useful as inhibitors of c-met
UA36194U (en) Use of quercetin as hepatoprotector
SI2496236T1 (sl) Prolilhidroksilazni inhibitorji

Legal Events

Date Code Title Description
GB Transfer or rights
HC Change of company name or juridical status
FG Grant or registration