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MX2010008685A - Farmacoforos duales-antagonistas muscarinicos de pde4. - Google Patents

Farmacoforos duales-antagonistas muscarinicos de pde4.

Info

Publication number
MX2010008685A
MX2010008685A MX2010008685A MX2010008685A MX2010008685A MX 2010008685 A MX2010008685 A MX 2010008685A MX 2010008685 A MX2010008685 A MX 2010008685A MX 2010008685 A MX2010008685 A MX 2010008685A MX 2010008685 A MX2010008685 A MX 2010008685A
Authority
MX
Mexico
Prior art keywords
pde4
antagonistics
muscarinic
pharmacophores
dual
Prior art date
Application number
MX2010008685A
Other languages
English (en)
Inventor
Zehong Wan
Hongxing Yan
James Francis Callahan
Guoliang Lin
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MX2010008685A publication Critical patent/MX2010008685A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a nuevos compuestos de Fórmula (I) (ver fórmula (I)) y a su uso en el tratamiento de enfermedades respiratorias, incluyendo enfermedades anti-inflamatorias y alérgicas tales como enfermedad pulmonar obstructiva crónica (COPD), asma, rinitis (por ejemplo, rinitis alérgica), dermatitis atópica o psoriasis.
MX2010008685A 2008-02-06 2009-02-05 Farmacoforos duales-antagonistas muscarinicos de pde4. MX2010008685A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2656808P 2008-02-06 2008-02-06
PCT/US2009/033129 WO2009100167A1 (en) 2008-02-06 2009-02-05 Dual pharmacophores-pde4-muscarinic antagonistics

Publications (1)

Publication Number Publication Date
MX2010008685A true MX2010008685A (es) 2010-08-30

Family

ID=40935341

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008685A MX2010008685A (es) 2008-02-06 2009-02-05 Farmacoforos duales-antagonistas muscarinicos de pde4.

Country Status (19)

Country Link
US (1) US8071588B2 (es)
EP (1) EP2247184A4 (es)
JP (1) JP2011511083A (es)
KR (1) KR20100125295A (es)
CN (1) CN101983009A (es)
AR (1) AR070563A1 (es)
AU (1) AU2009212409A1 (es)
BR (1) BRPI0907519A2 (es)
CA (1) CA2714418A1 (es)
CL (1) CL2009000249A1 (es)
CR (1) CR11666A (es)
DO (1) DOP2010000239A (es)
EA (1) EA201070917A1 (es)
IL (1) IL207346A0 (es)
MX (1) MX2010008685A (es)
PE (1) PE20091563A1 (es)
TW (1) TW200946525A (es)
UY (1) UY31636A1 (es)
WO (1) WO2009100167A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR081377A1 (es) 2010-05-10 2012-08-29 Gilead Sciences Inc Compuestos de pirazolopiridina bifuncionales
EP3072943B1 (en) 2015-03-26 2018-05-02 Idemitsu Kosan Co., Ltd. Dibenzofuran/carbazole-substituted benzonitriles
WO2016198691A1 (en) 2015-06-11 2016-12-15 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

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WO2003032989A1 (en) * 2001-10-18 2003-04-24 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors
US7544675B2 (en) 2002-04-18 2009-06-09 Ucb, S.A. Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions
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Also Published As

Publication number Publication date
EA201070917A1 (ru) 2011-02-28
EP2247184A1 (en) 2010-11-10
CL2009000249A1 (es) 2009-09-11
CN101983009A (zh) 2011-03-02
CR11666A (es) 2011-04-28
CA2714418A1 (en) 2009-08-13
DOP2010000239A (es) 2011-03-31
JP2011511083A (ja) 2011-04-07
IL207346A0 (en) 2010-12-30
EP2247184A4 (en) 2012-07-18
KR20100125295A (ko) 2010-11-30
TW200946525A (en) 2009-11-16
PE20091563A1 (es) 2009-11-05
AR070563A1 (es) 2010-04-21
BRPI0907519A2 (pt) 2015-07-28
AU2009212409A1 (en) 2009-08-13
WO2009100167A1 (en) 2009-08-13
US20090203677A1 (en) 2009-08-13
US8071588B2 (en) 2011-12-06
UY31636A1 (es) 2009-08-03

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