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MX2010001938A - Metodos para preparar compuestos basados en 4-fenil-6-(2,2,2-trifl uoro-1-feniletoxi)pirimidina. - Google Patents

Metodos para preparar compuestos basados en 4-fenil-6-(2,2,2-trifl uoro-1-feniletoxi)pirimidina.

Info

Publication number
MX2010001938A
MX2010001938A MX2010001938A MX2010001938A MX2010001938A MX 2010001938 A MX2010001938 A MX 2010001938A MX 2010001938 A MX2010001938 A MX 2010001938A MX 2010001938 A MX2010001938 A MX 2010001938A MX 2010001938 A MX2010001938 A MX 2010001938A
Authority
MX
Mexico
Prior art keywords
preparing
methods
yrimidine
phenylethoxy
trifluoro
Prior art date
Application number
MX2010001938A
Other languages
English (en)
Inventor
Wenxue Wu
Ramanaiah C Kanamarlapudi
Jie Yan
Haiming Zhang
Shinya Iimura
Qiuling Song
Mark Stephen Bednarz
Hugh Alfred Burgoon Jr
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of MX2010001938A publication Critical patent/MX2010001938A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen métodos útiles para preparar compuestos de la fórmula l: (ver fórmula I) y sus sales. También se describen intermediarios útiles en la preparación de estos compuestos.
MX2010001938A 2007-08-24 2008-08-22 Metodos para preparar compuestos basados en 4-fenil-6-(2,2,2-trifl uoro-1-feniletoxi)pirimidina. MX2010001938A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95774407P 2007-08-24 2007-08-24
PCT/US2008/073950 WO2009029499A1 (en) 2007-08-24 2008-08-22 Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds

Publications (1)

Publication Number Publication Date
MX2010001938A true MX2010001938A (es) 2010-03-11

Family

ID=40040082

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001938A MX2010001938A (es) 2007-08-24 2008-08-22 Metodos para preparar compuestos basados en 4-fenil-6-(2,2,2-trifl uoro-1-feniletoxi)pirimidina.

Country Status (16)

Country Link
US (3) US20090062540A1 (es)
EP (3) EP2529740A1 (es)
JP (1) JP5553752B2 (es)
KR (1) KR101582697B1 (es)
CN (1) CN101801384B (es)
AU (1) AU2008293679B2 (es)
BR (1) BRPI0815754B1 (es)
CA (1) CA2697368C (es)
ES (2) ES2656798T3 (es)
HK (1) HK1143749A1 (es)
IL (2) IL203669A (es)
MX (1) MX2010001938A (es)
NZ (1) NZ583017A (es)
RU (1) RU2493156C2 (es)
WO (1) WO2009029499A1 (es)
ZA (1) ZA201000785B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
TWI439457B (zh) * 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法
MX2010010799A (es) * 2008-03-31 2011-03-25 Univ Columbia Metodo de diagnostico, prevencion y tratamiento de las enfermedades de la masa osea.
WO2011053977A1 (en) 2009-11-02 2011-05-05 The Trustees Of Columbia University In The City Of New York Compounds and methods for inhibiting serotonin synthesis
TW201245183A (en) 2010-11-05 2012-11-16 Lexicon Pharmaceuticals Inc Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
JP6221148B2 (ja) * 2012-02-09 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング カルボキサミジン化合物の調製方法
WO2018060949A1 (en) 2016-09-30 2018-04-05 Roivant Sciences Gmbh Tryptophan hydroxylase inhibitors for use in the treatment of liver diseases
CN116496496B (zh) * 2023-04-27 2024-11-05 中国石油大学(华东) 一种基于三嗪共价框架材料（CTFs）制备单位点催化剂的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866181A (en) * 1986-08-29 1989-09-12 Aldrich-Boranes, Inc. Process for producing optically active alcohols
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
ATE168671T1 (de) * 1991-03-21 1998-08-15 Solutia Europ Nv Sa Verbessertes katalytisches verfahren zur selektiven alkylierung von aromatischen kohlenwasserstoffen
DE4131924A1 (de) * 1991-09-25 1993-07-08 Hoechst Ag Substituierte 4-alkoxypyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
WO1998014436A1 (en) * 1996-10-02 1998-04-09 Dupont Pharmaceuticals Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same
US6388084B1 (en) * 1999-12-06 2002-05-14 Hoffmann-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
FR2804427B1 (fr) * 2000-01-27 2002-09-06 Rhodia Chimie Sa Procede de preparation de cetones alpha-halogenees
MY129000A (en) * 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
GB0213122D0 (en) 2002-06-07 2002-07-17 Glaxo Group Ltd Compounds
TW200407310A (en) 2002-06-07 2004-05-16 Glaxo Group Ltd Compounds
AU2004232392A1 (en) * 2003-04-21 2004-11-04 Ustav Organicke Chemie A Biochemie Akademie Ved Ceske Republiky (Purin-6-yl) amino acid and production method thereof
AU2004249430B2 (en) * 2003-06-20 2011-08-18 Galderma Research & Development, S.N.C. Novel compounds that modulate PPARgamma type receptors, and use thereof in cosmetic or pharmaceutical compositions
BRPI0416238A (pt) * 2003-11-05 2007-01-02 Hoffmann La Roche compostos, processo para a sua preparação, composição farmacêutica que compreende os mesmos, uso dos compostos e métodos para o tratamento e/ou a prevenção de doenças que são moduladas por ppar(delta) e/ou agonistas ppar(alfa)
BRPI0620756B1 (pt) * 2005-12-29 2021-06-01 Tersera Therapeutics Llc Derivados de aminoácido multicíclicos, formulação farmacêutica compreendendo os mesmos e seus usos para inibir a atividade de triptofano hidroxilase 1 (tph1)
US7855291B2 (en) * 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
CN101801385A (zh) * 2007-07-26 2010-08-11 莱西肯医药有限公司 影响胃肠传输和胃排空的方法和可用于该方法的化合物
TWI439457B (zh) * 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法

Also Published As

Publication number Publication date
IL226441A (en) 2014-06-30
JP2010536879A (ja) 2010-12-02
ES2656798T3 (es) 2018-02-28
EP3318260A1 (en) 2018-05-09
ZA201000785B (en) 2011-04-28
BRPI0815754A2 (pt) 2017-05-30
EP2187887A1 (en) 2010-05-26
IL203669A (en) 2015-07-30
US7968729B2 (en) 2011-06-28
CA2697368A1 (en) 2009-03-05
US8575362B2 (en) 2013-11-05
AU2008293679A1 (en) 2009-03-05
JP5553752B2 (ja) 2014-07-16
RU2493156C2 (ru) 2013-09-20
BRPI0815754B1 (pt) 2022-03-22
IL226441A0 (en) 2013-06-27
WO2009029499A1 (en) 2009-03-05
CN101801384A (zh) 2010-08-11
KR101582697B1 (ko) 2016-01-05
NZ583017A (en) 2012-02-24
US20100240906A1 (en) 2010-09-23
US20110301349A1 (en) 2011-12-08
CN101801384B (zh) 2012-03-21
ES2848152T3 (es) 2021-08-05
EP3318260B1 (en) 2020-09-23
US20090062540A1 (en) 2009-03-05
HK1143749A1 (en) 2011-01-14
KR20100046026A (ko) 2010-05-04
EP2187887B1 (en) 2017-11-15
CA2697368C (en) 2016-06-21
AU2008293679B2 (en) 2013-09-12
EP2529740A1 (en) 2012-12-05
RU2010111125A (ru) 2011-09-27

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