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MX2010001746A - Pirimidinas biciclicas fusionadas. - Google Patents

Pirimidinas biciclicas fusionadas.

Info

Publication number
MX2010001746A
MX2010001746A MX2010001746A MX2010001746A MX2010001746A MX 2010001746 A MX2010001746 A MX 2010001746A MX 2010001746 A MX2010001746 A MX 2010001746A MX 2010001746 A MX2010001746 A MX 2010001746A MX 2010001746 A MX2010001746 A MX 2010001746A
Authority
MX
Mexico
Prior art keywords
fused bicyclic
bicyclic pyrimidines
pyrimidines
fused
pi3k
Prior art date
Application number
MX2010001746A
Other languages
English (en)
Inventor
Matthias Vennemann
Volker Gekeler
Thomas Beckers
Astrid Zimmermann
Swen Hoelder
Hemant Joshi
Gerrit Beneke
Armin Zuelch
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/en
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MX2010001746A publication Critical patent/MX2010001746A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de fórmula (I) (ver fórmula I) los tautómeros o los estereoisómeros de éstos, o las sales de éstos, donde el anillo 8 y la pirirnidina a la que está fusionado, R4, R5, R6, y R7 tienen los valores indicados en la descripción y las reivindicaciones, y son inhibidores eficaces de la vía P13K/Akt.
MX2010001746A 2007-08-14 2008-08-14 Pirimidinas biciclicas fusionadas. MX2010001746A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (en) 2007-10-18 2007-10-18 Novel fused pyrimidines
PCT/EP2008/060690 WO2009021992A2 (en) 2007-08-14 2008-08-14 Fused bicyclic pyrimidines

Publications (1)

Publication Number Publication Date
MX2010001746A true MX2010001746A (es) 2010-03-10

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001746A MX2010001746A (es) 2007-08-14 2008-08-14 Pirimidinas biciclicas fusionadas.

Country Status (38)

Country Link
US (2) US7776864B2 (es)
EP (1) EP2188291B1 (es)
JP (1) JP5344637B2 (es)
KR (1) KR20100053556A (es)
CN (1) CN101778851B (es)
AR (1) AR067945A1 (es)
AU (1) AU2008288392B2 (es)
BR (1) BRPI0815207A2 (es)
CA (1) CA2694058C (es)
CL (1) CL2008002398A1 (es)
CO (1) CO6260077A2 (es)
CR (1) CR11270A (es)
CY (1) CY1113486T1 (es)
DK (1) DK2188291T3 (es)
DO (1) DOP2010000058A (es)
EA (1) EA020996B1 (es)
EC (1) ECSP109964A (es)
ES (1) ES2396177T3 (es)
HK (1) HK1146273A1 (es)
HN (1) HN2010000313A (es)
HR (1) HRP20121022T1 (es)
IL (1) IL203163A (es)
MA (1) MA31608B1 (es)
MX (1) MX2010001746A (es)
MY (1) MY169738A (es)
NZ (1) NZ583267A (es)
PA (1) PA8793201A1 (es)
PE (1) PE20090944A1 (es)
PL (1) PL2188291T3 (es)
PT (1) PT2188291E (es)
RS (1) RS52559B (es)
SI (1) SI2188291T1 (es)
SV (1) SV2010003483A (es)
TN (1) TN2010000070A1 (es)
TW (1) TWI439272B (es)
UA (1) UA99735C2 (es)
UY (1) UY31293A1 (es)
WO (1) WO2009021992A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2508524A3 (en) * 2006-10-19 2012-10-24 Takeda Pharmaceutical Company Limited Indole compound
SI2188291T1 (sl) 2007-08-14 2013-01-31 Bayer Intellectual Property Gmbh Zliti biciklični pirimidini
US8415376B2 (en) 2008-05-30 2013-04-09 Amgen Inc. Inhibitors of PI3 kinase
CA2752114C (en) * 2009-02-13 2017-06-20 Bayer Pharma Aktiengesellschaft Fused pyrimidines as akt inhibitors
US8957064B2 (en) * 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
US20120071475A1 (en) 2009-04-27 2012-03-22 Shionogi & Co., Ltd. Urea derivatives having pi3k-inhibiting activity
CA2805015A1 (en) * 2010-07-13 2012-01-19 Stuart Ince Bicyclic pyrimidines
JP5926727B2 (ja) 2010-07-28 2016-05-25 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 置換イミダゾ［１，２−ｂ］ピリダジン
HUE026323T2 (en) 2011-04-07 2016-05-30 Bayer Ip Gmbh Imidazopyridazines as AKT kinase inhibitors
BR112015017331B1 (pt) 2013-01-23 2022-01-11 Astrazeneca Ab Compostos de formula i, forma cristalina, uso dos compostos, combinação e composição
WO2014146144A2 (en) * 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
TW201920185A (zh) 2017-09-15 2019-06-01 美商艾杜諾生物科技公司 吡唑并嘧啶酮化合物及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0112038A (pt) 2000-06-30 2003-04-01 Wyeth Corp Triazolopirimidinas substituìdas como agentes anticâncer
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
US7579355B2 (en) 2003-04-24 2009-08-25 Merck & Co., Inc. Inhibitors of Akt activity
DE602005026509D1 (de) 2004-04-09 2011-04-07 Merck Sharp & Dohme Hemmer der akt aktivität
TW200618800A (en) * 2004-08-03 2006-06-16 Uriach Y Compania S A J Heterocyclic compounds
AU2005290081B2 (en) 2004-08-23 2010-12-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US7910561B2 (en) 2004-12-15 2011-03-22 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
ATE543821T1 (de) 2004-12-28 2012-02-15 Exelixis Inc Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
JP2008530111A (ja) 2005-02-14 2008-08-07 メルク エンド カムパニー インコーポレーテッド Ａｋｔ活性の阻害剤
EP1898903B8 (en) 2005-06-10 2013-05-15 Merck Sharp & Dohme Corp. Inhibitors of akt activity
SI2188291T1 (sl) 2007-08-14 2013-01-31 Bayer Intellectual Property Gmbh Zliti biciklični pirimidini
US8957064B2 (en) * 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines

Also Published As

Publication number Publication date
HN2010000313A (es) 2013-03-18
EA201000298A1 (ru) 2010-10-29
US20090137607A1 (en) 2009-05-28
CR11270A (es) 2010-05-19
PL2188291T3 (pl) 2013-06-28
PT2188291E (pt) 2012-12-20
HRP20121022T1 (hr) 2013-01-31
AR067945A1 (es) 2009-10-28
CN101778851A (zh) 2010-07-14
NZ583267A (en) 2012-03-30
EP2188291B1 (en) 2012-09-19
WO2009021992A2 (en) 2009-02-19
KR20100053556A (ko) 2010-05-20
AU2008288392B2 (en) 2013-10-24
US20100184782A1 (en) 2010-07-22
ECSP109964A (es) 2010-03-31
DK2188291T3 (da) 2013-01-07
DOP2010000058A (es) 2010-02-28
MA31608B1 (fr) 2010-08-02
TW200922592A (en) 2009-06-01
JP5344637B2 (ja) 2013-11-20
CY1113486T1 (el) 2016-06-22
SV2010003483A (es) 2010-07-06
PE20090944A1 (es) 2009-08-09
CO6260077A2 (es) 2011-03-22
UA99735C2 (uk) 2012-09-25
CA2694058A1 (en) 2009-02-19
CL2008002398A1 (es) 2009-07-31
JP2010535848A (ja) 2010-11-25
UY31293A1 (es) 2009-03-31
MY169738A (en) 2019-05-14
RS52559B (en) 2013-04-30
AU2008288392A1 (en) 2009-02-19
ES2396177T3 (es) 2013-02-19
IL203163A (en) 2015-01-29
HK1146273A1 (en) 2011-05-20
EP2188291A2 (en) 2010-05-26
WO2009021992A3 (en) 2009-04-16
CN101778851B (zh) 2013-05-08
TWI439272B (zh) 2014-06-01
SI2188291T1 (sl) 2013-01-31
US8614218B2 (en) 2013-12-24
PA8793201A1 (es) 2009-04-23
TN2010000070A1 (en) 2011-09-26
BRPI0815207A2 (pt) 2017-03-28
CA2694058C (en) 2016-06-07
EA020996B1 (ru) 2015-03-31
US7776864B2 (en) 2010-08-17

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