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MX2009012716A - Nuevas fenilpirrolidinas disustituidas como moduladores de la neurotransmision catecolaminergica cortical. - Google Patents

Nuevas fenilpirrolidinas disustituidas como moduladores de la neurotransmision catecolaminergica cortical.

Info

Publication number
MX2009012716A
MX2009012716A MX2009012716A MX2009012716A MX2009012716A MX 2009012716 A MX2009012716 A MX 2009012716A MX 2009012716 A MX2009012716 A MX 2009012716A MX 2009012716 A MX2009012716 A MX 2009012716A MX 2009012716 A MX2009012716 A MX 2009012716A
Authority
MX
Mexico
Prior art keywords
modulators
phenylpyrrolidines
new disubstituted
cortical
catecholaminergic neurotransmission
Prior art date
Application number
MX2009012716A
Other languages
English (en)
Inventor
Lars Swanson
Nicholas Waters
Clas Sonesson
Fredrik Pettersson
Susanna Waters
Original Assignee
Nsab Af Neurosearch Sweden Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nsab Af Neurosearch Sweden Ab filed Critical Nsab Af Neurosearch Sweden Ab
Publication of MX2009012716A publication Critical patent/MX2009012716A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invención proporciona compuestos los cuales incrementan los niveles extracelulares de catecolaminas, dopamina y norepinefrina, en las áreas corticales del cerebro de mamíferos y más específicamente al uso de 3-(arilo disustituido)-pirrolidina s para el tratamiento de trastornos del sistema nervioso central.
MX2009012716A 2007-06-05 2008-06-04 Nuevas fenilpirrolidinas disustituidas como moduladores de la neurotransmision catecolaminergica cortical. MX2009012716A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94199307P 2007-06-05 2007-06-05
SE0701386 2007-06-05
PCT/EP2008/056912 WO2008148799A1 (en) 2007-06-05 2008-06-04 New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Publications (1)

Publication Number Publication Date
MX2009012716A true MX2009012716A (es) 2009-12-14

Family

ID=39672106

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012716A MX2009012716A (es) 2007-06-05 2008-06-04 Nuevas fenilpirrolidinas disustituidas como moduladores de la neurotransmision catecolaminergica cortical.

Country Status (11)

Country Link
US (1) US20100197760A1 (es)
EP (1) EP2155669B1 (es)
JP (1) JP2010529080A (es)
CN (1) CN101711234A (es)
AT (1) ATE508110T1 (es)
AU (1) AU2008258597A1 (es)
CA (1) CA2689692A1 (es)
DE (1) DE602008006720D1 (es)
MX (1) MX2009012716A (es)
NZ (1) NZ581363A (es)
WO (1) WO2008148799A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA98783C2 (en) 2007-06-05 2012-06-25 Нсаб, Филиал Аф Ньюросерч Свиден Аб, Свериге Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
JP5621087B2 (ja) 2008-11-24 2014-11-05 インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー 皮質のカテコールアミン作動性神経伝達のモジュレーターとして有用な新規な３−フェニル−アゼチジン誘導体
WO2010058019A1 (en) 2008-11-24 2010-05-27 Nsab, Filial Af Neurosearch Sweden Ab, Sverige 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
SG193576A1 (en) * 2011-03-31 2013-10-30 Chevron Usa Inc Novel process and catalyst system for improving dewaxing catalyst stability and lubricant oil yield

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2878264A (en) * 1959-03-17 Substituted amino alcohols
US364414A (en) * 1887-06-07 Gael hollweg
US3118907A (en) * 1961-08-14 1964-01-21 Mead Johnson & Co 3-substituted-3-pyrrolidinols
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
CA2105666C (en) 1991-04-17 2006-02-14 Kjell Anders Ivan Svensson New centrally acting substituted phenylazacycloalkanes
US5129962A (en) * 1991-10-22 1992-07-14 International Business Machines Corporation Tacky, no-clean thermally dissipated soldering flux
US20020169155A1 (en) * 1998-09-04 2002-11-14 Millennium Pharmaceuticals, Inc. Chemokine receptor anagonists and methods of use therefor
SE9904723D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
SE9904724D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
TWI308976B (en) * 2003-02-14 2009-04-21 Chunghwa Picture Tubes Ltd Process and structure of linquid crystal panel with one drop fill
WO2004096139A2 (en) * 2003-04-24 2004-11-11 Incyte Corporation Aza spiro alkane derivatives as inhibitors of metalloproteases
CN1902177A (zh) * 2003-09-22 2007-01-24 万有制药株式会社 新哌啶衍生物
TWI350168B (en) * 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
KR100690854B1 (ko) * 2005-11-08 2007-03-09 엘지전자 주식회사 멀티태스킹이 가능한 휴대용 단말기 및 그의 멀티태스킹처리방법
CN101341135B (zh) * 2005-12-21 2013-08-14 詹森药业有限公司 治疗mch-1介导的疾病的取代的吡嗪酮衍生物
US20080070649A1 (en) * 2006-09-06 2008-03-20 Uchida Toshi K Free Space Optical Interconnections in Cellular Telephone Handsets

Also Published As

Publication number Publication date
AU2008258597A1 (en) 2008-12-11
CA2689692A1 (en) 2008-12-11
ATE508110T1 (de) 2011-05-15
US20100197760A1 (en) 2010-08-05
DE602008006720D1 (de) 2011-06-16
EP2155669A1 (en) 2010-02-24
EP2155669B1 (en) 2011-05-04
NZ581363A (en) 2011-10-28
CN101711234A (zh) 2010-05-19
WO2008148799A1 (en) 2008-12-11
JP2010529080A (ja) 2010-08-26

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