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MX2009011579A - Pirimidinonas como moduladores de caseina cinasa ii (ck2). - Google Patents

Pirimidinonas como moduladores de caseina cinasa ii (ck2).

Info

Publication number
MX2009011579A
MX2009011579A MX2009011579A MX2009011579A MX2009011579A MX 2009011579 A MX2009011579 A MX 2009011579A MX 2009011579 A MX2009011579 A MX 2009011579A MX 2009011579 A MX2009011579 A MX 2009011579A MX 2009011579 A MX2009011579 A MX 2009011579A
Authority
MX
Mexico
Prior art keywords
casein kinase
pyrimidinones
modulators
fomula
pathways
Prior art date
Application number
MX2009011579A
Other languages
English (en)
Inventor
Wei Xu
Patrick Kearney
Naing Aay
Arlyn Arcalas
Wai Ki Vicky Chan
Hongwang Du
Brian Kane
Elena S Koltun
Michael Pack
Peiwen Zhou
Amy L Tsuhako
Ping Huang
Moon Hwan Kim
Jeffry Kimo Curtis
Cristiana A Zaharia
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of MX2009011579A publication Critical patent/MX2009011579A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describe un compuesto que tiene la fórmula I: (ver fórmula (I)) o una sal farmacéuticamente aceptable del mismo, en donde X, R1, R2 y R3 son como se define en la descripción; composiciones farmacéuticas del mismo y métodos de uso del mismo. Los compuestos de la fórmula I son inhibidores de las vías de Caseína cinasa II (CK2).
MX2009011579A 2007-04-25 2008-04-24 Pirimidinonas como moduladores de caseina cinasa ii (ck2). MX2009011579A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92635807P 2007-04-25 2007-04-25
PCT/US2008/005419 WO2008143759A1 (en) 2007-04-25 2008-04-24 Pyrimidinones as casein kinase ii (ck2) modulators

Publications (1)

Publication Number Publication Date
MX2009011579A true MX2009011579A (es) 2009-11-11

Family

ID=39645308

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011579A MX2009011579A (es) 2007-04-25 2008-04-24 Pirimidinonas como moduladores de caseina cinasa ii (ck2).

Country Status (9)

Country Link
US (1) US8324231B2 (es)
EP (1) EP2074114B1 (es)
JP (1) JP5330375B2 (es)
KR (1) KR20100017359A (es)
CN (1) CN102317281A (es)
AU (1) AU2008253684B2 (es)
HK (1) HK1133012A1 (es)
MX (1) MX2009011579A (es)
WO (1) WO2008143759A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102408380B (zh) * 2011-12-22 2014-04-16 浙江大学 5-氨基嘧啶硫酮类化合物及其制备方法
JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
SG10201912524QA (en) 2013-01-15 2020-04-29 Incyte Holdings Corp Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
JP2016528298A (ja) 2013-08-23 2016-09-15 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用なフロピリジン及びチエノピリジンカルボキシアミド化合物
CN103804312B (zh) * 2014-02-17 2016-04-20 四川百利药业有限责任公司 一类氮杂环化合物及其制备方法和用途
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US10280156B2 (en) * 2014-08-28 2019-05-07 Medizinische Universität Wien Heteroaromatic chalcone derivatives and their medical use
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
EP3474855B1 (en) * 2016-06-24 2022-01-26 Polaris Pharmaceuticals, Inc. Ck2 inhibitors, compositions and methods thereof
JP7092742B2 (ja) * 2016-07-13 2022-06-28 セントレ ナシオナル デ ラ ルシェルシェ シエンティフィーク ケモカインの生物活性を中和するためのピリミジノン誘導体およびその使用
CN111032656B (zh) * 2017-08-22 2022-12-02 捷思英达医药技术（上海）有限公司 杂环化合物激酶抑制剂及其药物组合物和应用
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
KR102337404B1 (ko) * 2020-01-03 2021-12-10 연세대학교 산학협력단 조직 재생용 조성물
CN111217862B (zh) * 2020-02-26 2023-01-31 陕西科技大学 一种4-芳基-6-二茂铁基-3,4-二氢嘧啶-2(1h)-酮的制备方法
EP4271673A1 (en) 2020-12-30 2023-11-08 Tyra Biosciences, Inc. Indazole compounds as kinase inhibitors
GB202213163D0 (en) * 2022-09-08 2022-10-26 Cambridge Entpr Ltd Novel compounds, compositions and therapeutic uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950526A (en) * 1970-04-20 1976-04-13 Sumitomo Chemical Company, Limited Quinazoline derivatives in pharmaceutical compositions for treating pain and inflammation
DE2118315C3 (de) * 1970-04-20 1975-04-03 Sumitomo Chemical Co., Ltd., Osaka (Japan) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
WO2001022950A2 (en) * 1999-09-24 2001-04-05 Shire Biochem Inc. Diosolane nucleoside analogs for the treatment or prevention of viral infection
WO2007048064A2 (en) 2005-10-21 2007-04-26 Exelixis, Inc. Amino-pyrimidines as casein kinase ii (ck2) modulators
CA2648809A1 (en) * 2006-04-19 2007-11-01 Novartis Ag Indazole compounds and methods for inhibition of cdc7
US8242129B2 (en) * 2007-04-25 2012-08-14 Exelixis, Inc. 6-phenylpyrimidinones as PIM modulators

Also Published As

Publication number Publication date
WO2008143759A1 (en) 2008-11-27
US8324231B2 (en) 2012-12-04
US20100144770A1 (en) 2010-06-10
AU2008253684B2 (en) 2014-02-27
JP2010525068A (ja) 2010-07-22
HK1133012A1 (en) 2010-03-12
EP2074114A1 (en) 2009-07-01
AU2008253684A1 (en) 2008-11-27
CN102317281A (zh) 2012-01-11
KR20100017359A (ko) 2010-02-16
JP5330375B2 (ja) 2013-10-30
EP2074114B1 (en) 2013-03-06

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