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MX2009010549A - Virus atenuados utiles para vacunas. - Google Patents

Virus atenuados utiles para vacunas.

Info

Publication number
MX2009010549A
MX2009010549A MX2009010549A MX2009010549A MX2009010549A MX 2009010549 A MX2009010549 A MX 2009010549A MX 2009010549 A MX2009010549 A MX 2009010549A MX 2009010549 A MX2009010549 A MX 2009010549A MX 2009010549 A MX2009010549 A MX 2009010549A
Authority
MX
Mexico
Prior art keywords
attenuated virus
subject
provides
genome
vaccines
Prior art date
Application number
MX2009010549A
Other languages
English (en)
Inventor
Eckhard Wimmer
Steve Skiena
Steffen Mueller
Bruce Futcher
Dimitris Papamichail
Coleman Jhon Robert
Cello Jeronimo
Original Assignee
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39808891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009010549(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found
Publication of MX2009010549A publication Critical patent/MX2009010549A/es

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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/13—Poliovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2770/00011—Details
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Abstract

La presente invención provee un virus atenuado el cual comprende un genoma viral modificado conteniendo sustituciones nucleótidas ingenieradas en múltiples localizaciones en el genoma, en donde las sustituciones introducen sinónimos de codones deoptimizados dentro del genoma. El virus atenuado instantáneo puede ser usado en una composición de vacuna para inducir una respuesta inmuno protectora en un sujeto. La invención también provee un método para sintetizar el virus atenuado instantáneo. Más aún, esta invención además provee un método para prevenir a un sujeto de ser afligido/infectado con una enfermedad asociada al virus comprendiendo administrar a el sujeto una dosis efectiva profiláctica de una composición de vacuna comprendiendo el virus atenuado instantáneo.
MX2009010549A 2007-03-30 2008-03-31 Virus atenuados utiles para vacunas. MX2009010549A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90938907P 2007-03-30 2007-03-30
US6866608P 2008-03-07 2008-03-07
PCT/US2008/058952 WO2008121992A2 (en) 2007-03-30 2008-03-31 Attenuated viruses useful for vaccines

Publications (1)

Publication Number Publication Date
MX2009010549A true MX2009010549A (es) 2010-03-15

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Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014010788A MX349825B (es) 2007-03-30 2008-03-31 Virus atenuados utiles para vacunas.
MX2009010549A MX2009010549A (es) 2007-03-30 2008-03-31 Virus atenuados utiles para vacunas.

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MX2014010788A MX349825B (es) 2007-03-30 2008-03-31 Virus atenuados utiles para vacunas.

Country Status (13)

Country Link
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