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MX2008013057A - Proteinas de enlace que comprenden regiones bisagra y regiones fc de inmunoglobulina que tienen funciones efectoras fc alteradas. - Google Patents

Proteinas de enlace que comprenden regiones bisagra y regiones fc de inmunoglobulina que tienen funciones efectoras fc alteradas.

Info

Publication number
MX2008013057A
MX2008013057A MX2008013057A MX2008013057A MX2008013057A MX 2008013057 A MX2008013057 A MX 2008013057A MX 2008013057 A MX2008013057 A MX 2008013057A MX 2008013057 A MX2008013057 A MX 2008013057A MX 2008013057 A MX2008013057 A MX 2008013057A
Authority
MX
Mexico
Prior art keywords
binding
binding proteins
hinge
domain
altered
Prior art date
Application number
MX2008013057A
Other languages
English (en)
Inventor
Baum Peter Robert
Erik Stephen Espling
Tan Phillip
Thompson Peter Armstrong
Original Assignee
Trubion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trubion Pharmaceuticals Inc filed Critical Trubion Pharmaceuticals Inc
Publication of MX2008013057A publication Critical patent/MX2008013057A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proveen proteínas de enlace que comprenden una o más de bisagra de inmunoglobulina de región Fc, y/o dominio CR3 y/o CR2 en donde una o más bisagras y/o región constante CH2 y/o dominio CH3 se modifica para alterar la afinidad de enlace de las proteínas de enlace y/o especificidad para un receptor cognado (e.g. un receptor Fc) y/o para proveer una o más especificidades de enlace nuevas a la bisagra y/o región constante que la inmunoglobulina sin modificar correspondiente no posee (e.g. afinidad para distintas clases de receptor cognado distinta de la clase de receptor cognado a la cual se enlaza específicamente la proteína de enlace sin modificar). Las proteínas de enlace de conformidad con la presente invención incluyen, por ejemplo, anticuerpos modificados, fragmentos de anticuerpos, proteínas de enlace recombinantes y proteínas de fusión dominio de enlace- inmunoglobulina molecularmente modificadas, incluyendo pequeños productos inmunofarmacéuticos modulares.
MX2008013057A 2006-04-14 2007-04-13 Proteinas de enlace que comprenden regiones bisagra y regiones fc de inmunoglobulina que tienen funciones efectoras fc alteradas. MX2008013057A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74489906P 2006-04-14 2006-04-14
PCT/US2007/066634 WO2007121354A2 (en) 2006-04-14 2007-04-13 Binding proteins comprising immunoglobulin hinge and fc regions having altered fc effector functions

Publications (1)

Publication Number Publication Date
MX2008013057A true MX2008013057A (es) 2009-04-07

Family

ID=38610404

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008013057A MX2008013057A (es) 2006-04-14 2007-04-13 Proteinas de enlace que comprenden regiones bisagra y regiones fc de inmunoglobulina que tienen funciones efectoras fc alteradas.

Country Status (9)

Country Link
US (1) US20080227958A1 (es)
EP (1) EP2007808A4 (es)
JP (1) JP2009538273A (es)
CN (1) CN101466733A (es)
AU (1) AU2007238034A1 (es)
BR (1) BRPI0710011A2 (es)
CA (1) CA2648849A1 (es)
MX (1) MX2008013057A (es)
WO (1) WO2007121354A2 (es)

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AT503889B1 (de) * 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F Multivalente immunglobuline
US7846434B2 (en) * 2006-10-24 2010-12-07 Trubion Pharmaceuticals, Inc. Materials and methods for improved immunoglycoproteins
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NZ774435A (en) 2009-11-02 2024-08-30 Univ Washington Therapeutic nuclease compositions and methods
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WO2012167011A1 (en) 2011-06-02 2012-12-06 Massachusetts Institute Of Technology Dsrna/dna hybrid genome replication intermediate of metakaryotic stem cells
FR2980271B1 (fr) * 2011-09-16 2013-10-11 Cisbio Bioassays Procede de determination de la glycosylation d'un anticorps
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EP2789630A1 (en) 2013-04-09 2014-10-15 EngMab AG Bispecific antibodies against CD3e and ROR1
EP3305916B1 (en) 2013-05-20 2019-06-26 BioVentures, LLC Gep5 model for multiple myeloma
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BR112016010025A2 (pt) 2013-11-11 2017-12-05 Chugai Pharmaceutical Co Ltd molécula de ligação de antígeno contendo região variável de anticorpo modificado
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US11952421B2 (en) 2014-10-09 2024-04-09 Bristol-Myers Squibb Company Bispecific antibodies against CD3EPSILON and ROR1
KR20180004094A (ko) * 2014-11-06 2018-01-10 칠드런스 내셔널 메디컬 센터 암 및 자가면역 질환을 위한 면역 요법
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EP3061826A1 (en) 2015-02-27 2016-08-31 Novartis AG Flavivirus replicons
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WO2019040674A1 (en) 2017-08-22 2019-02-28 Sanabio, Llc SOLUBLE INTERFERON RECEPTORS AND USES THEREOF
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Also Published As

Publication number Publication date
CN101466733A (zh) 2009-06-24
EP2007808A4 (en) 2010-07-21
BRPI0710011A2 (pt) 2011-08-02
EP2007808A2 (en) 2008-12-31
JP2009538273A (ja) 2009-11-05
AU2007238034A1 (en) 2007-10-25
US20080227958A1 (en) 2008-09-18
WO2007121354A3 (en) 2008-12-11
CA2648849A1 (en) 2007-10-25
WO2007121354A2 (en) 2007-10-25

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