MX2007012947A - Composiciones biomejoradas. - Google Patents
Composiciones biomejoradas.Info
- Publication number
- MX2007012947A MX2007012947A MX2007012947A MX2007012947A MX2007012947A MX 2007012947 A MX2007012947 A MX 2007012947A MX 2007012947 A MX2007012947 A MX 2007012947A MX 2007012947 A MX2007012947 A MX 2007012947A MX 2007012947 A MX2007012947 A MX 2007012947A
- Authority
- MX
- Mexico
- Prior art keywords
- arb
- composition
- solubility
- solubility enhancing
- present
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invencion, se relaciona con un metodo para aumentar la biodisponibilidad de Bloqueadores del Receptor de Angiotensina II (ARBs) al preparar una composicion de un ARB con al menos un agente para intensificar la solubilidad. En particular, la presente invencion se relaciona con agentes para intensificar la solubilidad que no solo actuen como intensificadores de solubilidad sino que tambien mejoran la velocidad de disolucion, particularmente en medios acidos o medianamente acidos, donde es minima la solubilidad del ARB. En la composicion, el ARB puede estar presente en la forma de una combinacion fisica, una dispersion, solucion o complejo de solidos con el agente para intensificar la solubilidad. La composicion de un ARB con el agente para intensificar la solubilidad se puede incorporar en una formulacion para liberacion inmediata o una liberacion controlada o cualquier otra liberacion modificada adecuada. Las formas de osificacion para liberacion inmediata que contienen la composicion de un ARB proporcionan una liberacion in vitro de al menos el 40% en medios acidos (pH < 3). Como resultado, la biodisponibilidad del ARB se puede aumentar en al menos un 20% segun se mide mediante Cmax, AUC0-t y AUCo-8.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN477MU2005 | 2005-04-18 | ||
IN315MU2006 | 2006-03-06 | ||
PCT/US2006/014422 WO2006113631A2 (en) | 2005-04-18 | 2006-04-18 | Bioenhanced compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007012947A true MX2007012947A (es) | 2008-04-09 |
Family
ID=37115820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007012947A MX2007012947A (es) | 2005-04-18 | 2006-04-18 | Composiciones biomejoradas. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1877042A4 (es) |
JP (1) | JP2008536929A (es) |
KR (1) | KR20080042039A (es) |
AU (1) | AU2006236497A1 (es) |
CA (1) | CA2605183A1 (es) |
IL (1) | IL186721A0 (es) |
MX (1) | MX2007012947A (es) |
WO (1) | WO2006113631A2 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007077581A2 (en) * | 2006-01-02 | 2007-07-12 | Rubicon Research Private Limited | Pharmaceutical compositions |
KR20090049089A (ko) * | 2006-09-05 | 2009-05-15 | 아스트라제네카 아베 | 칸데사르탄 실렉세틸을 포함하는 약학 조성물 |
US7923026B2 (en) | 2006-10-20 | 2011-04-12 | Solvay Pharmaceuticals B.V. | Embedded micellar nanoparticles |
EP2083799A1 (en) * | 2006-10-20 | 2009-08-05 | Solvay Pharmaceuticals B.V. | Micellar nanoparticles of chemical substances |
WO2008064338A2 (en) * | 2006-11-22 | 2008-05-29 | Rubicon Research Pvt. Ltd. | Valsartan formulation for pulsatile delivery |
US20100041644A1 (en) * | 2006-11-28 | 2010-02-18 | Laboratorios Liconsa, S. A. | Stabilized solid pharmaceutical composition of candesartan cilexetil |
AR064104A1 (es) * | 2006-12-05 | 2009-03-11 | Novartis Ag | Formas de dosificacion en microemulsion de valsartan, y metodos para elaborarlas |
WO2008076780A2 (en) * | 2006-12-14 | 2008-06-26 | Isp Investments Inc. | Amorphous valsartan and the production thereof |
WO2008084504A2 (en) * | 2007-01-12 | 2008-07-17 | Rubicon Research Private Limited | Pharmaceutical compositions of angiotensin ii receptor blockers |
WO2008134013A2 (en) * | 2007-04-25 | 2008-11-06 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical excipient complex |
WO2008149338A2 (en) * | 2007-06-06 | 2008-12-11 | Dexcel Ltd. | Process for forming solid oral dosage forms of angiotensin ii receptor antagonists |
RU2010104960A (ru) * | 2007-08-01 | 2011-09-10 | Тева Фармасьютикал Индастриес Лтд. (Il) | Фармацевтическая композиция кандесартана |
CA2701695A1 (en) * | 2007-10-09 | 2009-04-16 | Novartis Ag | Pharmaceutical formulation of valsartan |
JP2011500647A (ja) * | 2007-10-19 | 2011-01-06 | アボット ゲーエムベーハー ウント カンパニー カーゲー | N−アリール尿素系化合物を含む固体分散体生成物 |
JP5222550B2 (ja) * | 2007-12-27 | 2013-06-26 | 財團法人工業技術研究院 | 徐放性組成物およびその製造方法 |
WO2009084040A1 (en) * | 2007-12-28 | 2009-07-09 | Rubicon Research Private Limited | Once a day formulation of angiotensin receptor blockers |
KR20100119578A (ko) * | 2008-02-28 | 2010-11-09 | 노파르티스 아게 | 발사르탄 고체 경구 투여 형태 및 이러한 제형물의 제조 방법 |
BRPI0913337A2 (pt) * | 2008-06-03 | 2017-05-23 | Novartis Ag | liberação pulsátil de valsartan |
DK2165702T3 (da) | 2008-09-17 | 2012-03-05 | Helm Ag | Stabile og let opløselige sammensætninger af candesartancilexetil fremstillet ved vådgranulering |
DE102008047910A1 (de) | 2008-09-19 | 2010-03-25 | Molkerei Meggle Wasserburg Gmbh & Co. Kg | Tablettierhilfsstoff auf Laktose- und Cellulosebasis |
CN102802611B (zh) * | 2009-06-25 | 2014-11-12 | 进洋制药株式会社 | 含氯沙坦羧酸的药物组合物及其生产方法 |
WO2011028016A2 (ko) * | 2009-09-04 | 2011-03-10 | 한올바이오파마주식회사 | 베타 아드레날린 차단제와 안지오텐신-2 수용체 길항제를 포함하는 약제학적제제 |
CA2864088C (en) * | 2012-02-08 | 2020-04-28 | Supernus Pharmaceuticals, Inc. | Modified release formulations of viloxazine |
WO2014088123A1 (en) | 2012-12-05 | 2014-06-12 | Sawai Pharmaceutical Co., Ltd. | Candesartan cilexetil-containing preparation |
WO2014119667A1 (ja) | 2013-01-30 | 2014-08-07 | 沢井製薬株式会社 | カンデサルタンシレキセチル含有医薬組成物 |
WO2016005994A2 (en) * | 2014-07-06 | 2016-01-14 | Gattefosse India Pvt. Ltd. | Pharmaceutical composition comprising solid dispersion of bcs class ii drugs with gelucires |
US9687475B1 (en) | 2016-03-24 | 2017-06-27 | Ezra Pharma Llc | Extended release pharmaceutical formulations with controlled impurity levels |
US9675585B1 (en) | 2016-03-24 | 2017-06-13 | Ezra Pharma | Extended release pharmaceutical formulations |
SG11202002864PA (en) | 2017-10-04 | 2020-04-29 | Celgene Corp | Compositions and methods of use of cis-4-[2-{[(3s,4r)-3-fluorooxan-4-yl] amino}-8-(2,4,6-trichloroanilino)-9h-purin-9-yl]-1-methylcyclohexane-1-carboxamide |
CN109350609A (zh) * | 2018-11-14 | 2019-02-19 | 常州大学 | 一种壳聚糖包裹玉米醇溶蛋白纳米粒的制备及负载金合欢素钠盐的应用 |
CN113933472B (zh) * | 2020-06-29 | 2024-07-09 | 武汉武药科技有限公司 | 测定替米沙坦固体制剂溶出度的溶出介质及其应用 |
CN112516105A (zh) * | 2020-12-10 | 2021-03-19 | 成都恒瑞制药有限公司 | 一种氯沙坦钾口服制剂及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US20030236236A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
JP3751287B2 (ja) * | 2002-03-27 | 2006-03-01 | バイエル薬品株式会社 | 小型化されたニフェジピン有核錠剤 |
EP1575581A1 (en) * | 2002-12-18 | 2005-09-21 | Novartis AG | Combinations of valsartan with cox-2 inhibitors |
US20050096365A1 (en) * | 2003-11-03 | 2005-05-05 | David Fikstad | Pharmaceutical compositions with synchronized solubilizer release |
HRP20031029A2 (en) * | 2003-12-12 | 2005-08-31 | Belupo - Lijekovi I Kozmetika D.D. | Process for production of inclusion complexes of valsartan with?-cylodextrin |
-
2006
- 2006-04-18 MX MX2007012947A patent/MX2007012947A/es unknown
- 2006-04-18 AU AU2006236497A patent/AU2006236497A1/en not_active Abandoned
- 2006-04-18 WO PCT/US2006/014422 patent/WO2006113631A2/en active Application Filing
- 2006-04-18 CA CA002605183A patent/CA2605183A1/en not_active Abandoned
- 2006-04-18 JP JP2008507777A patent/JP2008536929A/ja active Pending
- 2006-04-18 EP EP06750455A patent/EP1877042A4/en not_active Withdrawn
- 2006-04-18 KR KR1020077026647A patent/KR20080042039A/ko not_active Application Discontinuation
-
2007
- 2007-10-17 IL IL186721A patent/IL186721A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1877042A4 (en) | 2011-03-02 |
JP2008536929A (ja) | 2008-09-11 |
WO2006113631A2 (en) | 2006-10-26 |
IL186721A0 (en) | 2008-02-09 |
WO2006113631A3 (en) | 2006-12-14 |
EP1877042A2 (en) | 2008-01-16 |
KR20080042039A (ko) | 2008-05-14 |
CA2605183A1 (en) | 2006-10-26 |
AU2006236497A1 (en) | 2006-10-26 |
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