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ME01075B - Antitijela - Google Patents

Antitijela

Info

Publication number
ME01075B
ME01075B MEP-2010-59A MEP5910A ME01075B ME 01075 B ME01075 B ME 01075B ME P5910 A MEP5910 A ME P5910A ME 01075 B ME01075 B ME 01075B
Authority
ME
Montenegro
Prior art keywords
amyloid
compositions
disorders
amyloidosis
diseases
Prior art date
Application number
MEP-2010-59A
Other languages
English (en)
French (fr)
Inventor
Andrea Pfeifer
Maria Pihlgren
Andreas Muhs
Ryan Watts
Original Assignee
Ac Immune Sa
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49474825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME01075(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ac Immune Sa, Genentech Inc filed Critical Ac Immune Sa
Priority claimed from PCT/US2007/073504 external-priority patent/WO2008011348A2/en
Publication of ME01075B publication Critical patent/ME01075B/me

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)

Abstract

Ovaj pronalazak se odnosi na postupke (metode) i kompozicije (smeše) za terapeutsku i dijagnostičku upotrebu u lečenju bolesti i poremećaja koji su prouzrokovani sa ili su vezani sa amiloidom ili amiloidu sličnim proteinima uključujući amiloidozu, grupu poremećaja i abnormalnosti vezanih sa amiloidnim proteinom kao što je Alchajmerova bolest. Ovaj pronalazak daje nove postupke (metode) i kompozicije (smeše) koji obuhvataju visoko specifična i visoko efikasna antitela koja imaju sposobnost da specifično prepoznaju i vezuju se za specifične epitope iz oblasti j3-amiloidnih proteina. Ova antitela koja su omogućena učenjem ovog pronalaska su naročito korisna (primenljiva) za lečenje bolesti i poremećaja koji su prouzrokovani sa ili su vezani sa amiloidom ili amiloidu sličnim proteinima uključujući amiloidozu, grupu bolesti i poremećaja vezanih sa formiranjem amiloidnih ploča (gomila) uključujući sekundarnu amiloidozu i amiloidozu vezanu sa starošću, uključujući, ali se ne ograničavajući samo na njih, neurološke poremećaje kao što je Alchajmerova bolest (AB).  
MEP-2010-59A 2006-07-14 2007-07-13 Antitijela ME01075B (me)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP06014730 2006-07-14
EP06020765 2006-10-02
US94328907P 2007-06-11 2007-06-11
US94349907P 2007-06-12 2007-06-12
PCT/US2007/073504 WO2008011348A2 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta

Publications (1)

Publication Number Publication Date
ME01075B true ME01075B (me) 2012-10-20

Family

ID=49474825

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-2010-59A ME01075B (me) 2006-07-14 2007-07-13 Antitijela
MEP-2013-132A ME01758B (me) 2006-07-14 2007-07-13 Humanizirano protutijelo protiv amiloida beta

Family Applications After (1)

Application Number Title Priority Date Filing Date
MEP-2013-132A ME01758B (me) 2006-07-14 2007-07-13 Humanizirano protutijelo protiv amiloida beta

Country Status (22)

Country Link
US (2) US20160272699A1 (me)
EP (1) EP3309172B1 (me)
KR (6) KR20150087435A (me)
CN (3) CN103524617B (me)
BR (1) BRPI0714713B1 (me)
CR (1) CR20140496A (me)
CY (1) CY1114604T1 (me)
DK (2) DK2468770T3 (me)
ES (2) ES2436112T3 (me)
HU (1) HUE038438T2 (me)
IL (1) IL254065B (me)
LT (1) LT2468770T (me)
ME (2) ME01075B (me)
MY (2) MY153248A (me)
NZ (1) NZ607881A (me)
PH (1) PH12012501882B1 (me)
PT (2) PT2468770T (me)
RS (2) RS53160B (me)
RU (1) RU2668161C2 (me)
SI (2) SI2046833T1 (me)
TR (1) TR201802814T4 (me)
TW (2) TW201815827A (me)

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Also Published As

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CY1114604T1 (el) 2016-10-05
SI2046833T1 (sl) 2013-12-31
US20160272699A1 (en) 2016-09-22
US20220227847A1 (en) 2022-07-21
KR20150087435A (ko) 2015-07-29
TW201815827A (zh) 2018-05-01
EP3309172B1 (en) 2021-09-29
RS56986B1 (sr) 2018-05-31
NZ607881A (en) 2014-11-28
DK2046833T5 (en) 2014-03-24
KR20170098978A (ko) 2017-08-30
CN101516911A (zh) 2009-08-26
SI2468770T1 (en) 2018-05-31
TWI608014B (zh) 2017-12-11
MY153248A (en) 2015-01-29
LT2468770T (lt) 2018-05-25
RU2668161C2 (ru) 2018-09-26
PT2046833E (pt) 2013-11-27
TR201802814T4 (tr) 2018-03-21
PH12012501882A1 (en) 2014-09-08
KR20180043854A (ko) 2018-04-30
CN101516911B (zh) 2016-11-16
CN103524617A (zh) 2014-01-22
CR20140496A (es) 2014-12-01
DK2468770T3 (en) 2018-03-12
HUE038438T2 (hu) 2018-10-29
KR20160049045A (ko) 2016-05-04
BRPI0714713A2 (pt) 2014-10-29
CN103524617B (zh) 2016-12-28
RS53160B (en) 2014-06-30
IL254065A0 (en) 2017-10-31
ME01758B (me) 2014-09-20
CN106831983B (zh) 2021-11-30
DK2046833T3 (da) 2013-10-28
KR20190003862A (ko) 2019-01-09
ES2661562T3 (es) 2018-04-02
ES2436112T9 (es) 2014-06-04
IL254065B (en) 2020-07-30
BRPI0714713B1 (pt) 2021-11-03
RU2013115283A (ru) 2014-10-10
KR20160147066A (ko) 2016-12-21
CN106831983A (zh) 2017-06-13
MY165105A (en) 2018-02-28
EP3309172A1 (en) 2018-04-18
TW201527319A (zh) 2015-07-16
ES2436112T3 (es) 2013-12-27
PH12012501882B1 (en) 2014-09-08
PT2468770T (pt) 2018-03-09

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