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MD228C2 - Method of preparation of 7-(2-(2-aminothiazolyl-4)-2-oxyiminoacetamido)-3-acetoxymethyl-3-cefem-4-carbonic acid or salts thereof with alcaline matals - Google Patents

Method of preparation of 7-(2-(2-aminothiazolyl-4)-2-oxyiminoacetamido)-3-acetoxymethyl-3-cefem-4-carbonic acid or salts thereof with alcaline matals

Info

Publication number
MD228C2
MD228C2 MD94-0269A MD940269A MD228C2 MD 228 C2 MD228 C2 MD 228C2 MD 940269 A MD940269 A MD 940269A MD 228 C2 MD228 C2 MD 228C2
Authority
MD
Moldova
Prior art keywords
acid
general formula
oxyiminoacetamido
cefem
acetoxymethyl
Prior art date
Application number
MD94-0269A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD228B1 (en
Inventor
Rene Heymes
Andre Lutz
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SU772439818A external-priority patent/SU822754A3/en
Priority claimed from FR7707307A external-priority patent/FR2383188A2/en
Priority claimed from SU802949072A external-priority patent/SU932986A3/en
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD228B1 publication Critical patent/MD228B1/en
Publication of MD228C2 publication Critical patent/MD228C2/en

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  • Cephalosporin Compounds (AREA)

Abstract

The invention relates to the preparation of new antibiotics of cefalosporinic class, especially 7-[2-(2-aminotriazolyl-4)-2-oxyiminoacetamido]-3-acetoxymethyl-3-cefem-4-carbonic acid or its salts with alkali metals of general formula(I)in the form of sin-isomer, wherein A-hydrogen or alkali metal that can be applied as medicines.The purpose of the invention is obtaining of new cefalosporine antibiotics extending the arsenal of remedies influenced on live organism.The method is realized by interaction of compounds of general formula II(II)wherein A1- group, eliminated by acid hydrolysis or hydrogenolysis with acid of general formula III(III)in the form of sin-isomer or with functional derivative of this acid, wherein R1 and R2 - group, eliminated by acid hydrolysis or hydrogenolysis,Forming compound of general formula IV(IV)in the form of sin-isomer wherein A1, R1 and R2 have indicated means, than is treated by one or some agents of acid hydrolysis or hydrogenolysis.The final product is separated in the form of free acid or its salt with alkali metals.
MD94-0269A 1977-01-18 1994-09-08 Method of preparation of 7-(2-(2-aminothiazolyl-4)-2-oxyiminoacetamido)-3-acetoxymethyl-3-cefem-4-carbonic acid or salts thereof with alcaline matals MD228C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SU772439818A SU822754A3 (en) 1976-01-23 1977-01-18 Method of preparing derivatives of 7-/-2-(2-aminothiazolyl-4)-2-oxyiminoacetamido/3-acetoxymethyl-3-cephem-4-carboxylic acid in the form of sin-isomers
FR7707307A FR2383188A2 (en) 1976-01-23 1977-03-11 Oximes of thiazolyl-acetamido cephalosporins - useful as antibacterials against Gram positive and negative species
SU802949072A SU932986A3 (en) 1977-03-11 1980-07-21 Process for producing 7-(2-aminothiazolyl-4)-(2-oxyimino-acetamido)-3-acetoxymethyl-2-cefem-4-carboxylic acid or its alkali metal salts

Publications (2)

Publication Number Publication Date
MD228B1 MD228B1 (en) 1995-06-30
MD228C2 true MD228C2 (en) 1995-11-30

Family

ID=27250721

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0269A MD228C2 (en) 1977-01-18 1994-09-08 Method of preparation of 7-(2-(2-aminothiazolyl-4)-2-oxyiminoacetamido)-3-acetoxymethyl-3-cefem-4-carbonic acid or salts thereof with alcaline matals

Country Status (1)

Country Link
MD (1) MD228C2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971778A (en) * 1972-05-12 1976-07-27 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971778A (en) * 1972-05-12 1976-07-27 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position

Also Published As

Publication number Publication date
MD228B1 (en) 1995-06-30

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