[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

MA44820B1 - Amides hétérocycliques a utiliser en tant qu'inhibiteurs de kinase - Google Patents

Amides hétérocycliques a utiliser en tant qu'inhibiteurs de kinase

Info

Publication number
MA44820B1
MA44820B1 MA44820A MA44820A MA44820B1 MA 44820 B1 MA44820 B1 MA 44820B1 MA 44820 A MA44820 A MA 44820A MA 44820 A MA44820 A MA 44820A MA 44820 B1 MA44820 B1 MA 44820B1
Authority
MA
Morocco
Prior art keywords
kinase inhibitors
heterocyclic amides
amides
heterocyclic
compounds
Prior art date
Application number
MA44820A
Other languages
English (en)
Other versions
MA44820A1 (fr
Inventor
Deepak Bandyopadhyay
Jianxing Kang
Marquis, Jr
Joshi M Ramanjulu
Singhaus, Jr
Patrick M Eidam
Peter J Gough
Philip Anthony Harris
Jae U Jeong
Bryan Wayne King
Shah Ami Lakdawala
Lara Kathryn Leister
Attiq Rahman
Clark A Sehon
Daohua Zhang
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of MA44820A1 publication Critical patent/MA44820A1/fr
Publication of MA44820B1 publication Critical patent/MA44820B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)

Abstract

L'invention concerne des composés de formule (i) dans laquelle x, y, z1, z2, z3, z4, r5, ra, m, a. L, et b ont la signification indiquée dans la description, ainsi que des procédés de fabrication et d'utilisation de ceux-ci.
MA44820A 2013-02-15 2014-02-14 Amides hétérocycliques a utiliser en tant qu'inhibiteurs de kinase MA44820B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361765664P 2013-02-15 2013-02-15
US201361790044P 2013-03-15 2013-03-15
PCT/IB2014/059004 WO2014125444A1 (fr) 2013-02-15 2014-02-14 Amides hétérocycliques à utiliser en tant qu'inhibiteurs de kinase

Publications (2)

Publication Number Publication Date
MA44820A1 MA44820A1 (fr) 2019-09-30
MA44820B1 true MA44820B1 (fr) 2020-06-30

Family

ID=50151350

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44820A MA44820B1 (fr) 2013-02-15 2014-02-14 Amides hétérocycliques a utiliser en tant qu'inhibiteurs de kinase

Country Status (37)

Country Link
US (6) US9556152B2 (fr)
EP (4) EP3342771B1 (fr)
JP (3) JP6321045B2 (fr)
KR (2) KR102267977B1 (fr)
CN (3) CN108774214B (fr)
AU (1) AU2014217453B2 (fr)
BR (4) BR122017002949A2 (fr)
CA (1) CA2900695C (fr)
CL (1) CL2015002279A1 (fr)
CR (3) CR20190511A (fr)
CY (2) CY1120320T1 (fr)
DK (2) DK3342771T3 (fr)
DO (3) DOP2015000196A (fr)
EA (2) EA031971B1 (fr)
ES (3) ES2855135T3 (fr)
HK (3) HK1249100A1 (fr)
HR (2) HRP20180900T1 (fr)
HU (2) HUE037763T2 (fr)
IL (3) IL240280B (fr)
LT (2) LT3342771T (fr)
MA (1) MA44820B1 (fr)
MX (1) MX360715B (fr)
MY (2) MY178552A (fr)
NZ (1) NZ628447A (fr)
PE (1) PE20151752A1 (fr)
PH (4) PH12015501675A1 (fr)
PL (2) PL2956452T3 (fr)
PT (2) PT3342771T (fr)
RS (2) RS61439B1 (fr)
SG (1) SG11201505796TA (fr)
SI (2) SI3342771T1 (fr)
TR (1) TR201808112T4 (fr)
TW (4) TWI638815B (fr)
UA (1) UA118259C2 (fr)
UY (1) UY35330A (fr)
WO (1) WO2014125444A1 (fr)
ZA (1) ZA201505267B (fr)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI638815B (zh) 2013-02-15 2018-10-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類（一）
RU2017109122A (ru) 2014-08-21 2018-09-21 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Способы лечения с использованием гетероциклических амидов в качестве ингибиторов киназы
JP6590927B2 (ja) * 2014-11-14 2019-10-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ソマトスタチン受容体サブタイプ４（ｓｓｔｒ４）作動薬としてのアリール及びヘテロアリール縮合テトラヒドロ−１，４−オキサゼピンアミド
EA201791289A1 (ru) 2014-12-11 2017-12-29 Президент Энд Феллоуз Оф Гарвард Колледж Ингибиторы клеточного некроза и связанные с ними способы
BR112017017411A2 (pt) 2015-02-13 2018-04-03 Glaxosmithkline Ip Dev Ltd Formas cristalinas de (s)-5-benzil-n-(5-metil-4-oxo- 2,3,4,5-tetraidrobenzo[b][1,4]oxazepin-3-il)-4h-1,2,4- triazol-3-carboxamida
WO2016139181A1 (fr) 2015-03-02 2016-09-09 Apeiron Biologics Ag Dérivés tétrahydrothiazépine bicycliques utiles pour le traitement de maladies infectieuses et/ou néoplasiques
UY36680A (es) * 2015-05-19 2016-12-30 Glaxosmithkline Ip Dev Ltd Amidas heterocíclicas como inhibidores de quinasa
US10294237B2 (en) 2015-06-22 2019-05-21 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic heterocyclic amide derivative
TWI763630B (zh) * 2015-07-02 2022-05-11 瑞士商赫孚孟拉羅股份公司 雙環內醯胺及其使用方法
KR102667914B1 (ko) 2015-07-22 2024-05-21 이난타 파마슈티칼스, 인코포레이티드 Rsv 저해제로서의 벤조다이아제핀 유도체
CN108431004B (zh) * 2015-10-23 2021-02-12 武田药品工业株式会社 杂环化合物
US10709692B2 (en) * 2015-12-04 2020-07-14 Denali Therapeutics Inc. Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1)
WO2017109724A1 (fr) 2015-12-21 2017-06-29 Glaxosmithkline Intellectual Property Development Limited Amides hétérocycliques utilisés en tant qu'inhibiteurs de kinase
US20170226129A1 (en) 2016-01-15 2017-08-10 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
AU2017213628B2 (en) 2016-02-05 2021-07-29 Denali Therapeutics Inc. Inhibitors of receptor-interacting protein kinase 1
WO2017146128A1 (fr) 2016-02-26 2017-08-31 大日本住友製薬株式会社 Dérivé d'imidazolylamide
WO2018007973A2 (fr) 2016-07-06 2018-01-11 Glaxosmithkline Intellectual Property Development Limited Procédé et intermédiaires pour la préparation de benzoxazépines
WO2018073193A1 (fr) 2016-10-17 2018-04-26 F. Hoffmann-La Roche Ag Lactames de pyridone bicycliques et leurs méthodes d'utilisation
TW201822637A (zh) 2016-11-07 2018-07-01 德商拜耳廠股份有限公司 用於控制動物害蟲的經取代磺醯胺類
TW201831464A (zh) 2016-11-18 2018-09-01 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺
TW201831478A (zh) 2016-12-02 2018-09-01 瑞士商赫孚孟拉羅股份公司 雙環醯胺化合物及其使用方法
JP7208137B2 (ja) 2016-12-09 2023-01-18 デナリ セラピューティクス インコーポレイテッド 化合物、組成物および方法
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
WO2018117196A1 (fr) 2016-12-20 2018-06-28 大日本住友製薬株式会社 Médicament ciblant une cellule souche cancéreuse
US10398706B2 (en) 2017-01-06 2019-09-03 Enanta Pharmaceuticals, Inc. Heteroaryldiazepine derivatives as RSV inhibitors
MX2019009687A (es) 2017-02-16 2019-12-18 Enanta Pharm Inc Procesos para la preparación de derivados de benzodiazepina.
US20200062735A1 (en) 2017-02-27 2020-02-27 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
JOP20190233A1 (ar) * 2017-04-14 2019-10-02 Biogen Ma Inc نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون
EP3612223B1 (fr) * 2017-04-17 2024-07-31 National Institute Of Biological Sciences, Beijing Traitement de la sénescence masculine
TWI794232B (zh) 2017-05-17 2023-03-01 美商戴納立製藥公司 激酶抑制劑及其用途
WO2018226801A1 (fr) 2017-06-07 2018-12-13 Enanta Pharmaceuticals, Inc. Dérivés d'aryldiazépine utilisés en tant qu'inhibiteurs du vrs
WO2019006295A1 (fr) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. Composés hétérocycliques utilisés en tant qu'inhibiteurs du vrs
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
NZ760749A (en) 2017-07-14 2024-08-30 Hoffmann La Roche Bicyclic ketone compounds and methods of use thereof
MX2020004084A (es) 2017-09-29 2020-07-29 Enanta Pharm Inc Agentes farmaceuticos como inhibidores del rsv para utilizar en combinacion.
MX2020003439A (es) 2017-10-11 2020-07-29 Hoffmann La Roche Compuestos biciclicos para usarse como inhibidores de cinasa de la proteina 1 de interaccion con receptores (rip1).
AU2018360270A1 (en) 2017-10-31 2020-03-26 F. Hoffmann-La Roche Ag Bicyclic sulfones and sulfoxides and methods of use thereof
KR102634720B1 (ko) 2017-11-13 2024-02-06 이난타 파마슈티칼스, 인코포레이티드 벤조디아제핀-2-온 및 벤조아제핀-2-온 유도체의 분할 방법
WO2019094920A1 (fr) 2017-11-13 2019-05-16 Enanta Pharmaceuticals, Inc. Dérivés d'azépin-2-one en tant qu'inhibiteurs du vrs
WO2019123219A1 (fr) 2017-12-20 2019-06-27 Glaxosmithkline Intellectual Property Development Limited Forme de sel cristalline de (s)-5-benzyl-n-(5-méthyl-4-oxo-2,3,4,5-tétrahydrobenzo[b][1,4]oxazépin-3-yl)-4h-1,2,4-triazole-3-carboxamide
EP3732176A1 (fr) 2017-12-29 2020-11-04 GlaxoSmithKline Intellectual Property Development Ltd Amides hétérocycliques utilisés en tant qu'inhibiteurs de kinase
WO2019199908A1 (fr) 2018-04-11 2019-10-17 Enanta Pharmaceuticals, Inc. Composés hétérocycliques en tant qu'inhibiteurs de vrs
EP3781571B1 (fr) 2018-04-20 2024-01-17 F. Hoffmann-La Roche AG Dérivés de n-[4-oxo-2,3-dihydro-pyrido[3,2-b][1,4]oxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxamide et composés similaires en tant qu'inhibiteurs de la kinase rip1 pour le traitement p.e. du syndrome de l'intestin irritable (sii)
CN110407770B (zh) * 2018-04-27 2022-12-30 复旦大学 3-取代-1,5-苯并氮杂䓬类化合物及其药物用途
MA52492B1 (fr) 2018-05-03 2023-09-27 Rigel Pharmaceuticals Inc Composés inhibiteurs de rip1, procédés de préparation et d'utilisation associés
HRP20231381T1 (hr) 2018-05-03 2024-03-01 Rigel Pharmaceuticals, Inc. Spojevi inhibitori rip1 i postupci za njihovo dobivanje i upotrebu
WO2019224774A1 (fr) 2018-05-23 2019-11-28 Glaxosmithkline Intellectual Property Development Limited Amides hétérocycliques en tant qu'inhibiteurs de kinase rip1
WO2019224773A1 (fr) 2018-05-23 2019-11-28 Glaxosmithkline Intellectual Property Development Limited Amides hétérocycliques en tant qu'inhibiteurs de kinase rip1
CN110642874B (zh) * 2018-06-26 2023-03-28 中国科学院上海有机化学研究所 一类细胞坏死抑制剂及其制备方法和用途
TW202019913A (zh) * 2018-06-26 2020-06-01 中國科學院上海有機化學研究所 細胞壞死抑制劑及其製備方法和用途
ES2815899T3 (es) * 2018-07-09 2021-03-31 Fis Fabbrica Italiana Sintetici Spa 2-Fluoro-3-nitrotolueno cristalino y procedimiento para la preparación del mismo
WO2020044206A1 (fr) 2018-08-29 2020-03-05 Glaxosmithkline Intellectual Property Development Limited Amides hétérocycliques utiles en tant qu'inhibiteurs de kinases destinés à être utilisés dans le traitement du cancer
CN109134448B (zh) * 2018-10-16 2020-11-27 中南大学湘雅医院 杂环化合物及其盐、制备方法、用途和药物
CN111138448B (zh) 2018-11-02 2022-08-02 中国科学院上海药物研究所 抑制rip1激酶的杂环酰胺及其用途
WO2020088194A1 (fr) 2018-11-02 2020-05-07 中国科学院上海药物研究所 Amide hétérocyclique inhibant la kinase rip1 et ses applications
CN113302193A (zh) 2019-01-11 2021-08-24 豪夫迈·罗氏有限公司 双环吡咯并三唑酮化合物及其使用方法
US20230026425A1 (en) * 2019-01-25 2023-01-26 Beijing Scitech-Mq Pharmaceuticals Limited Acylamino bridged heterocyclic compound, and composition and application thereof
MX2021011144A (es) 2019-03-18 2022-01-18 Enanta Pharm Inc Derivados de las benzodiazepinas como inhibidores del vsr.
WO2020210246A1 (fr) 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Composés hétérocycliques utilisés comme inhibiteurs du vrs
CN113840595A (zh) 2019-05-17 2021-12-24 葛兰素史密斯克莱知识产权发展有限公司 基质组合物，其包含(S)-5-苄基-N-(5-甲基-4-氧代-2,3,4,5-四氢苯并[b][1,4]氧氮杂环庚三烯-3-基)-4H-1,2,4-三唑-3-甲酰胺
JP7299350B2 (ja) * 2019-05-31 2023-06-27 メッドシャイン ディスカバリー インコーポレイテッド Ｒｉｐ－１キナーゼ阻害剤としての二環式化合物およびその使用
US20210040115A1 (en) * 2019-08-09 2021-02-11 Bisichem Co., Ltd. Fused ring heteroaryl compounds as ripk1 inhibitors
US11564930B2 (en) 2019-09-06 2023-01-31 Rigel Pharmaceuticals, Inc. RIP1 inhibitory compounds and methods for making and using the same
US11718612B2 (en) 2019-09-06 2023-08-08 Board Of Regents, The University Of Texas System Inhibitors of receptor interacting protein kinase I for the treatment of disease
US11479543B2 (en) 2019-09-06 2022-10-25 Rigel Pharmaceuticals, Inc. Heterocyclic RIP1 kinase inhibitors
JP2022550099A (ja) 2019-09-27 2022-11-30 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム 疾患の処置のための受容体相互作用プロテインキナーゼｉの阻害剤
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
CA3153297A1 (fr) 2019-10-04 2021-04-08 Adam SZYMANIAK Composes heterocycliques antiviraux
MX2022005509A (es) * 2019-11-07 2022-10-18 Rigel Pharmaceuticals Inc Compuestos inhibidores de rip1 heterociclicos.
CA3162605A1 (fr) 2019-11-26 2021-06-03 Board Of Regents, The University Of Texas System Inhibiteurs de la proteine kinase 1 interagissant avec les recepteurs pour le traitement d'une maladie
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
EP4110765A4 (fr) * 2020-02-28 2024-03-06 Board of Regents, The University of Texas System Inhibiteurs de la protéine kinase i interagissant avec le récepteur pour le traitement d'une maladie
AR121717A1 (es) 2020-04-02 2022-06-29 Rigel Pharmaceuticals Inc Inhibidores de rip1k
TW202214617A (zh) 2020-06-02 2022-04-16 法商賽諾菲公司 作為ｒｉｐｋ１抑制劑之異㗁唑啶及其用途
AR122703A1 (es) 2020-07-01 2022-09-28 Rigel Pharmaceuticals Inc Inhibidores de rip1k
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
WO2022037585A1 (fr) * 2020-08-18 2022-02-24 Hutchison Medipharma Limited Composés de pyrimidinone et leurs utilisations
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
CN114716427B (zh) * 2021-01-07 2024-04-26 成都贝诺科成生物科技有限公司 一种作为rip抑制剂的化合物及其制备方法和用途
WO2022171111A1 (fr) * 2021-02-10 2022-08-18 Zai Lab (Us) Llc Composé bicyclique fusionné hétéroaryle utile en tant qu'inhibiteur de la rip1-kinase et ses utilisations
WO2022171110A1 (fr) * 2021-02-10 2022-08-18 Zai Lab (Us) Llc Composés tricycliques fusionnés en tant qu'inhibiteurs de rip1-kinase et leurs utilisations
TW202300490A (zh) * 2021-03-11 2023-01-01 美商雷傑製藥公司 雜環rip1激酶抑制劑
CN113045560B (zh) * 2021-03-30 2022-09-06 港科鹏禾生物(苏州)有限公司 一种酰胺类衍生物及其制备方法和应用
BR112023020229A2 (pt) 2021-04-02 2023-11-14 Hoffmann La Roche Processos para a preparação de um composto bicíclico de cetona quiral, composto de n-amino lactama quiral, composto de sal imidato e composto hidroxicetoéster, composto, ou um sal farmaceuticamente aceitável do mesmo e invenção
US20240228506A1 (en) * 2021-04-27 2024-07-11 Merck Sharp & Dohme Llc Ripk1 inhibitors and methods of use
CN115246796A (zh) * 2021-04-27 2022-10-28 中国科学院上海有机化学研究所 一种抑制细胞程序性死亡的化合物及其制备方法
TW202321211A (zh) 2021-08-10 2023-06-01 美商艾伯維有限公司 菸鹼醯胺ripk1抑制劑
CN115806557A (zh) * 2021-09-14 2023-03-17 中国科学院上海有机化学研究所 抑制细胞程序性死亡的化合物及其制备方法
WO2023068881A1 (fr) * 2021-10-22 2023-04-27 주식회사 보로노이바이오 Dérivé aryle ou hétéroaryle, et composition pharmaceutique le comprenant en tant que principe actif pour la prévention ou le traitement de maladies associées aux kinases
CN113876778B (zh) * 2021-11-05 2023-04-14 中日友好医院(中日友好临床医学研究所) Kw2449在制备改善类风湿性关节炎药物中的应用
CA3237975A1 (fr) 2021-11-11 2023-05-19 Elisabeth Defossa Isoxazolidines en tant qu'inhibiteurs de ripk1 et leur utilisation
KR20230100646A (ko) * 2021-12-24 2023-07-05 제일약품주식회사 Ripk1 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물
TW202334164A (zh) 2022-01-12 2023-09-01 美商戴納立製藥公司 （Ｓ）－５－苄基－Ｎ－（５－甲基－４－側氧基－２，３，４，５－四氫吡啶並［３，２－ｂ］［１，４］氧氮呯－３－基）－４Ｈ－１，２，４－三唑－３－甲醯胺的晶型
CN118647617A (zh) 2022-03-16 2024-09-13 江苏恒瑞医药股份有限公司 稠杂环类化合物、其制备方法及其在医药上的应用
WO2023240379A1 (fr) * 2022-06-13 2023-12-21 南京医工医药技术有限公司 Dérivé d'imidazolinone et son utilisation
CN114736197B (zh) * 2022-06-13 2022-09-13 南京医工医药技术有限公司 咪唑啉酮衍生物及其用途
CN117447460A (zh) * 2022-07-13 2024-01-26 南京天印健华医药科技有限公司 作为ripk1抑制剂的杂环化合物
WO2024040155A1 (fr) 2022-08-19 2024-02-22 Genzyme Corporation Isoxazolidines en tant qu'inhibiteurs de ripk1 et leur utilisation
TW202423921A (zh) * 2022-08-22 2024-06-16 美商安塔製藥公司 稠合的雜雙環抗病毒劑
WO2024158665A1 (fr) * 2023-01-23 2024-08-02 Genzyme Corporation Formulations médicamenteuses de 4-(3,3-difluoro-2,2-diméthyl-propanoyl)-3,5-dihydro-2h-pyrido [3,4-f] [1,4] oxazépine-9-carbonitrile

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5239065B2 (fr) 1971-11-17 1977-10-03
EP0166357A3 (fr) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzo-lactames condensés et leurs compositions pharmaceutiques
US4692522A (en) 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US5206234A (en) 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
JP3358069B2 (ja) * 1991-12-24 2002-12-16 武田薬品工業株式会社 三環性複素環類、その製造法及び剤
ATE235472T1 (de) 1995-06-07 2003-04-15 Merck & Co Inc N-(2-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepi - 3-yl)-3-amide
WO1998041510A1 (fr) 1997-03-14 1998-09-24 Shionogi & Co., Ltd. Nouveaux derives du benzolactame et compositions medicamenteuses les contenant
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
FR2781483A1 (fr) * 1998-07-21 2000-01-28 Hoechst Marion Roussel Inc Derives de thioazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicament et compositions pharmaceutiques les renfermant
JP2003503476A (ja) 1999-07-06 2003-01-28 バーテックス ファーマシューティカルズ インコーポレイテッド 環化アミド誘導体
MXPA02005070A (es) 1999-11-18 2003-09-25 Antexpharma Inc 1-benzazepinas sustituidas y derivados de las mismas.
MXPA02009729A (es) 2000-04-03 2003-03-27 Bristol Myers Squibb Pharma Co Lactamas ciclicas como inhibidores de la produccion de la proteina a-beta.
CA2404023A1 (fr) 2000-04-03 2001-10-11 Richard E. Olson Lactames cycliques utilises comme inhibiteurs de la production de la proteine beta-amyloide
US6509333B2 (en) 2000-06-01 2003-01-21 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of Aβ protein production
DE10054279A1 (de) 2000-11-02 2002-05-16 Apotech Res & Dev Ltd Verwendung von Liganden von Todesrezeptoren oder RIP zur Auslösung des Caspase-unabhängigen Zelltods und Verbindungen zur Inhibition des Caspase-unabhängigen Zelltods
CA2447687A1 (fr) 2001-05-16 2002-12-19 Antexpharma, Inc. 1-benzazepines substituees et leurs derives
US7057046B2 (en) * 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
AU2003229678A1 (en) 2003-04-15 2004-11-04 Dirk Koczan Method for diagnosing rheumatoid arthritis or osteoarthritis
TW200509910A (en) * 2003-05-02 2005-03-16 Elan Pharm Inc Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
US20080019909A1 (en) 2003-09-17 2008-01-24 Francis Ka-Ming Chan Modulation of Programmed Necrosis
EP1640012A1 (fr) 2004-09-24 2006-03-29 Salama, Zoser B. nat.rer.Dr. Agents pharmaceutiques comprenant des constituants du sang 10 kDa et l'utilisation dans la prophylaxe et dans le traitement des troubles du système immunitaire
US20060067942A1 (en) 2004-09-24 2006-03-30 Salama Zoser B Pharmaceutical agent comprising amino acids, peptides, proteins and/or fractions and fragments thereof and the use of same in the prophylaxis and treatment of immune system deficiency in humans and animals
FR2894968B1 (fr) 2005-12-20 2008-02-22 Trophos Sa Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
CN101674826A (zh) * 2005-12-20 2010-03-17 哈佛大学校长及研究员协会 化合物、筛选和治疗方法
FR2899108B1 (fr) 2006-03-31 2012-02-03 Trophos Utilisation de derives du cholest-4-en-3-one pour l'obtention d'un medicament cytoprotecteur
US8007790B2 (en) 2006-04-03 2011-08-30 Stowers Institute For Medical Research Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
FR2907783A1 (fr) 2006-10-30 2008-05-02 Trophos Sa Nouveaux composes chimiques, leurs procedes de synthese et leur utilisation a titre de medicament, particulierement a titre de medicament cytoprotecteur, neuroprotecteur ou cardioprotecteur
US20080226645A1 (en) 2007-01-10 2008-09-18 Wyeth Methods and compositions for assessment and treatment of asthma
US20100144715A1 (en) 2007-02-28 2010-06-10 Hoyt Scott B Substituted Benzodiazepinones, Benzoxazepinones and Benzothiazepinones as Sodium Channel Blockers
JP5239065B2 (ja) 2007-04-20 2013-07-17 株式会社大一商会 遊技機
US20090099242A1 (en) 2007-08-15 2009-04-16 Cuny Gregory D Heterocyclic inhibitors of necroptosis
FR2934596B1 (fr) 2008-07-30 2015-04-10 Trophos Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
WO2010075290A1 (fr) 2008-12-22 2010-07-01 President And Fellows Of Harvard College Inhibiteurs hétérocycliques insaturés de la nécroptose
US8257921B1 (en) 2008-12-22 2012-09-04 Schering Corporation NRIP1 regulation of apolipoprotein A1
EP2381775A4 (fr) 2008-12-23 2012-08-15 Harvard College Inhibiteurs de la nécroptose de petite taille moléculaire
FR2940650B1 (fr) 2008-12-29 2017-01-27 Trophos Nouveaux derives d'oxime du 3,5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant,et procede de preparation
US7622106B1 (en) 2009-03-06 2009-11-24 Board Of Regents, The University Of Texas System Necrosis assay
KR101155506B1 (ko) 2009-07-08 2012-06-15 고려대학교 산학협력단 활성산소조절 유전자를 이용한 ｔｎｆ-알파 유도 질병의 치료제 및 예방제의 스크리닝 방법
EP2519260A2 (fr) 2009-12-31 2012-11-07 Deutsches Krebsforschungszentrum Nouveaux modulateurs de signalisation par trail
US20130005726A1 (en) 2010-03-08 2013-01-03 Derek Abbott Compositions and methods for treating inflammatory disorders
EP2560629B1 (fr) 2010-04-23 2020-06-03 Massachusetts Eye & Ear Infirmary Compositions et procédés de conservation de cellules de photorécepteurs et de cellules épithéliales de pigment rétinien
CA2805669C (fr) 2010-07-16 2018-08-21 Agios Pharmaceuticals, Inc. Compositions therapeutiquement actives et methode d'utilisation correspondante
US20120022116A1 (en) 2010-07-20 2012-01-26 Huayun Deng Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex
US20140024598A1 (en) 2010-11-01 2014-01-23 Demetrios Vavvas Methods and compositions for preserving retinal ganglion cells
WO2012125544A2 (fr) 2011-03-11 2012-09-20 President And Fellows Of Harvard College Inhibiteurs de la nécroptose et leurs méthodes d'utilisation
WO2013013826A1 (fr) 2011-07-27 2013-01-31 Friedrich-Alexander-Universität Erlangen-Nürnberg Inhibiteurs de la nécroptose pour le traitement de maladies inflammatoires du tractus gastro-intestinal
WO2013043662A1 (fr) 2011-09-22 2013-03-28 Marv Enterprises Llc Méthode de traitement de la sclérose en plaques
CN102343102A (zh) 2011-10-19 2012-02-08 柳忠辉 激活素受体相互作用蛋白2基因在制备药物中的应用
US20140357570A1 (en) 2011-10-21 2014-12-04 Massachusetts Eye And Ear Infirmary Compositions comprising necrosis inhibitors, such as necrostatins, alone or in combination, for promoting axon regeneration and nerve function, thereby treating cns disorders
KR101410332B1 (ko) 2012-02-29 2014-06-24 코아스템(주) 중간엽 기질세포 배양용 항산화 조성물 및 이의 용도
ES2446494B1 (es) 2012-03-28 2015-03-16 Consejo Superior De Investigaciones Científicas (Csic) Aplicación terapéutica de necrostatina-1 en esteatohepatitis
WO2014022102A1 (fr) 2012-08-01 2014-02-06 Amgen Inc. Procédés d'utilisation de composés anti-apoptotiques pour moduler une ou plusieurs propriétés d'une culture de cellules
CA2877223C (fr) 2012-08-06 2019-08-27 Brainstorm Cell Therapeutics Ltd. Procedes de generation de cellules souches mesechymateuses qui secretent des facteurs neurotrophiques
ES2878196T3 (es) 2012-12-26 2021-11-18 Koninklijke Philips Nv Evaluación de la actividad de la vía de señalización celular mediante el uso de una o más combinaciones lineales de expresiones de genes diana
WO2014126127A1 (fr) 2013-02-13 2014-08-21 国立大学法人北海道大学 Composition médicamenteuse destinée au traitement d'une maladie se rapportant à la nécroptose et procédé de criblage de son principe actif
TWI638815B (zh) * 2013-02-15 2018-10-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類（一）
CN105593373A (zh) 2013-02-27 2016-05-18 博德研究所 T细胞平衡基因表达、物质组合物及其使用方法
US9725452B2 (en) 2013-03-15 2017-08-08 Presidents And Fellows Of Harvard College Substituted indoles and pyrroles as RIP kinase inhibitors
RU2017109122A (ru) 2014-08-21 2018-09-21 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Способы лечения с использованием гетероциклических амидов в качестве ингибиторов киназы
AU2017213628B2 (en) 2016-02-05 2021-07-29 Denali Therapeutics Inc. Inhibitors of receptor-interacting protein kinase 1

Also Published As

Publication number Publication date
TW201443042A (zh) 2014-11-16
DOP2018000088A (es) 2018-10-31
JP6352571B1 (ja) 2018-07-04
CN105121432A (zh) 2015-12-02
KR20150119174A (ko) 2015-10-23
PL2956452T3 (pl) 2018-08-31
JP2016512488A (ja) 2016-04-28
TWI637951B (zh) 2018-10-11
CN106928203B (zh) 2020-02-07
US20170008878A1 (en) 2017-01-12
IL256502A (en) 2018-02-28
TWI638815B (zh) 2018-10-21
DK3342771T3 (da) 2021-02-08
KR102228764B1 (ko) 2021-03-18
CY1123915T1 (el) 2022-05-27
US20190262356A1 (en) 2019-08-29
UY35330A (es) 2014-08-29
EA201792039A1 (ru) 2018-01-31
PH12018500341A1 (en) 2018-09-10
DOP2015000196A (es) 2016-05-15
HUE053215T2 (hu) 2021-06-28
IL256502B (en) 2018-11-29
MY195183A (en) 2023-01-11
MY178552A (en) 2020-10-16
HRP20180900T1 (hr) 2018-07-13
MX2015010572A (es) 2015-11-16
TW201819370A (zh) 2018-06-01
EP2956452B1 (fr) 2018-03-21
BR122017002946A2 (pt) 2019-09-10
HK1213545A1 (zh) 2016-07-08
PT2956452T (pt) 2018-06-01
CN108774214B (zh) 2021-03-09
ES2672530T3 (es) 2018-06-14
KR20190018558A (ko) 2019-02-22
ES2814556T3 (es) 2021-03-29
SI3342771T1 (sl) 2021-04-30
PT3342771T (pt) 2021-02-11
PH12018500343A1 (en) 2018-09-10
CR20190512A (es) 2020-01-08
EA028991B1 (ru) 2018-01-31
UA118259C2 (uk) 2018-12-26
DK2956452T3 (en) 2018-06-06
BR122017002949A2 (pt) 2019-09-10
EP3375780A1 (fr) 2018-09-19
CR20190511A (es) 2020-01-08
US20190201413A1 (en) 2019-07-04
CN108774214A (zh) 2018-11-09
SG11201505796TA (en) 2015-08-28
WO2014125444A1 (fr) 2014-08-21
TWI648274B (zh) 2019-01-21
IL240280A0 (en) 2015-09-24
SI2956452T1 (en) 2018-06-29
LT2956452T (lt) 2018-06-11
CN106928203A (zh) 2017-07-07
MA44820A1 (fr) 2019-09-30
KR102267977B1 (ko) 2021-06-21
PH12015501675A1 (en) 2015-10-19
BR112015019627B1 (pt) 2022-08-30
TR201808112T4 (tr) 2018-07-23
LT3342771T (lt) 2021-03-10
US20180098998A1 (en) 2018-04-12
HK1253099A1 (zh) 2019-06-06
AU2014217453A1 (en) 2015-08-13
CN105121432B (zh) 2018-08-03
US10292987B2 (en) 2019-05-21
AU2014217453B2 (en) 2016-04-14
RS57332B1 (sr) 2018-08-31
ES2855135T3 (es) 2021-09-23
IL240280B (en) 2018-04-30
PE20151752A1 (es) 2015-11-25
BR112015019627A2 (pt) 2017-07-18
JP2018150372A (ja) 2018-09-27
US9624202B2 (en) 2017-04-18
EP3508484A1 (fr) 2019-07-10
US10933070B2 (en) 2021-03-02
HRP20210252T1 (hr) 2021-04-02
IL256500A (en) 2018-02-28
JP6321045B2 (ja) 2018-05-09
CA2900695C (fr) 2021-10-12
CA2900695A1 (fr) 2014-08-21
NZ628447A (en) 2016-08-26
CY1120320T1 (el) 2019-07-10
TW201819369A (zh) 2018-06-01
TW201819368A (zh) 2018-06-01
BR122017002951A2 (pt) 2020-01-28
MX360715B (es) 2018-11-13
EP3342771B1 (fr) 2020-11-25
EP3375780B1 (fr) 2020-06-03
EP3508484B1 (fr) 2021-04-07
EA201591506A1 (ru) 2016-01-29
EA031971B1 (ru) 2019-03-29
PL3342771T3 (pl) 2021-06-14
CL2015002279A1 (es) 2016-07-08
PH12018500342A1 (en) 2018-09-10
CR20150420A (es) 2015-10-19
HK1249100A1 (zh) 2018-10-26
JP2018111712A (ja) 2018-07-19
US20150353533A1 (en) 2015-12-10
EP2956452A1 (fr) 2015-12-23
IL256500B (en) 2018-11-29
RS61439B1 (sr) 2021-03-31
HUE037763T2 (hu) 2018-09-28
TWI648273B (zh) 2019-01-21
EP3342771A1 (fr) 2018-07-04
US9556152B2 (en) 2017-01-31
DOP2018000089A (es) 2018-06-30
US10940154B2 (en) 2021-03-09
ZA201505267B (en) 2017-08-30
US20170183332A1 (en) 2017-06-29

Similar Documents

Publication Publication Date Title
MA44820B1 (fr) Amides hétérocycliques a utiliser en tant qu'inhibiteurs de kinase
MA42109A (fr) Amides hétérocycliques utilisés en tant qu'inhibiteurs de kinase
MA40301B1 (fr) Composés indolecarboxamides utiles comme inhibiteurs de kinase
JO3392B1 (ar) مركبات عطرية حلقية غير متجانسة كمركبات مضادة للالتهاب
ZA201701299B (en) Glycosidase inhibitors
RS54492B1 (en) KINASE INHIBITOR REGULATING THE SIGNAL PATH OF APOPTOSIS
CU20170057A7 (es) Derivados de feniltriazol sustituido con hidroxialquilo
MA35434B1 (fr) Amino-quinazolines en tant qu'inhibiteurs de kinase
RS54730B1 (sr) Inhibitori beta sekretaze
UA117521C2 (uk) Заміщені [1,2,4]триазольні та імідазольні сполуки як фунгіциди
CR20140468A (es) Inhibidores de diacilglicerol aciltransferasa 2
CR20150061A (es) Compuesto de pirazolopirimidinas
CO2017000134A2 (es) Compuestos de [1,2,4]triazol e imidazol sustituidos
MA38884A1 (fr) Composé de triazolopyridine, compositions et procédés d'utilisation associés
IN2014MN02244A (fr)
MA40281B1 (fr) Composés de pyrazole et leur utilisation en tant qu' agents de blocage des canaux calciques de type t
MA39152B1 (fr) Cyclopentanes substitués en 1,2 utilisés comme antagonistes du récepteur d'orexine
MX2015015786A (es) Compuestos de n-(tetrazol-5-il)- y n-(triazol-5-il) arilcarboxamida sustituidos y su uso como herbicidas.
MA38645B1 (fr) Nouveaux inhibiteurs de cyp17/antiandrogènes
EA201691982A1 (ru) 5,6-дизамещенные пиридин-2-карбоксамиды в качестве агонистов каннабиноидных рецепторов
PH12018501181A1 (en) Phenyl derivatives as cannabinoid receptor 2 agonists
EA201692289A1 (ru) Замещенные [1,2,4]триазольные и имидазольные соединения в качестве фунгицидов
EA201691999A1 (ru) Новые сульфониламинобензамидные соединения
EA201790191A1 (ru) Новые сульфониламинобензамидные соединения
MA38857A1 (fr) Dérivés de 1-(pipérazin-1-yl)-2-([1,2,4]triazol-1-yl)-éthanone