MA42160A - Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii - Google Patents
Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type iiInfo
- Publication number
- MA42160A MA42160A MA042160A MA42160A MA42160A MA 42160 A MA42160 A MA 42160A MA 042160 A MA042160 A MA 042160A MA 42160 A MA42160 A MA 42160A MA 42160 A MA42160 A MA 42160A
- Authority
- MA
- Morocco
- Prior art keywords
- thalassemia
- cell culture
- beta
- receptor ligand
- vitro cell
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Optics & Photonics (AREA)
- Urology & Nephrology (AREA)
Abstract
La présente invention concerne des procédés de traitement de la bêta-thalassémie chez un sujet comprenant l'administration d'un inhibiteur de signalisation du récepteur d'actine ii (actrii) (par exemple, un piège à ligand activine) et l'utilisation d'une ou plusieurs méthodes de culture cellulaire in vitro. ) sélection du sujet à traiter selon les méthodes fournies ici; et / ou (ii) la surveillance du sujet traité selon les méthodes fournies ici.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562164367P | 2015-05-20 | 2015-05-20 | |
US201662320032P | 2016-04-08 | 2016-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA42160A true MA42160A (fr) | 2018-03-28 |
Family
ID=57320751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA042160A MA42160A (fr) | 2015-05-20 | 2016-05-19 | Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii |
Country Status (8)
Country | Link |
---|---|
US (2) | US10548976B2 (fr) |
EP (2) | EP3298034A4 (fr) |
JP (2) | JP2018522579A (fr) |
CN (1) | CN108350057A (fr) |
CA (1) | CA2986432A1 (fr) |
HK (1) | HK1252174A1 (fr) |
MA (1) | MA42160A (fr) |
WO (1) | WO2016187378A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2018145985A (ru) | 2012-11-02 | 2019-02-18 | Селджин Корпорейшн | Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
TWI773117B (zh) | 2014-12-03 | 2022-08-01 | 美商西建公司 | 活化素-actrii拮抗劑及治療貧血之用途 |
CA2986432A1 (fr) | 2015-05-20 | 2016-11-24 | Celgene Corporation | Procedes de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii |
EP3370754A4 (fr) | 2015-11-04 | 2019-10-23 | Acceleron Pharma Inc. | Méthodes pour augmenter les taux d'érythrocytes et traiter l'érythropoïèse inefficace |
EP3538123A4 (fr) | 2016-11-10 | 2020-10-14 | Keros Therapeutics, Inc. | Variants de type iia du récepteur de l'activine et leurs méthodes d'utilisation |
WO2018128080A1 (fr) * | 2017-01-06 | 2018-07-12 | オリンパス株式会社 | Système d'observation de cellules |
EP4428147A3 (fr) * | 2017-11-09 | 2024-10-30 | Keros Therapeutics, Inc. | Variants du récepteur de l'activine de type iia et leurs procédés d'utilisation |
JP7510875B2 (ja) | 2018-01-12 | 2024-07-04 | ケロス セラピューティクス インコーポレイテッド | アクチビンiib型受容体変異体および同変異体を含む医薬組成物 |
CA3098679A1 (fr) * | 2018-05-09 | 2019-11-14 | Keros Therapeutics, Inc. | Variants du recepteur de l'activine de type iia et leurs procedes d'utilisation |
JP7388679B2 (ja) * | 2019-05-28 | 2023-11-29 | 学校法人 東洋大学 | 熱中症マーカー及びその利用 |
WO2021189019A1 (fr) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Chimères de type ii du récepteur d'activine et leurs méthodes d'utilisation |
MX2022013592A (es) * | 2020-04-28 | 2023-01-18 | Acceleron Pharma Inc | Proteinas actrii y uso en el tratamiento de la hipertension pulmonar postcapilar. |
EP4240399A4 (fr) * | 2020-11-06 | 2024-10-09 | Acceleron Pharma Inc | Formulations comprenant des variants polypeptidiques actrii |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000046349A1 (fr) | 1999-02-04 | 2000-08-10 | Technion Research & Development Foundation Ltd. | Methode et appareil de renouvellement et de multiplication de cellules souches hematopoietiques et/ou de progeniteurs |
AU2002213251B2 (en) | 2000-10-16 | 2007-06-14 | Bristol-Myers Squibb Company | Protein scaffolds for antibody mimics and other binding proteins |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
ATE472609T1 (de) | 2001-04-26 | 2010-07-15 | Amgen Mountain View Inc | Kombinatorische bibliotheken von monomerdomänen |
ES2426005T3 (es) | 2004-07-23 | 2013-10-18 | Acceleron Pharma Inc. | Polipéptidos del receptor ACTRII, procedimientos y composiciones |
EP1824796A4 (fr) | 2004-11-16 | 2010-02-17 | Avidia Res Inst | Squelettes proteiques et leurs utilisations |
KR20200041386A (ko) | 2005-11-23 | 2020-04-21 | 악셀레론 파마 인코포레이티드 | 액티빈-actrⅱa 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
PT2124999E (pt) | 2006-12-18 | 2013-01-22 | Acceleron Pharma Inc | Antagonistas de activina-actrii e usos para tratar anemia |
US20100028332A1 (en) | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
KR20140137463A (ko) | 2007-02-01 | 2014-12-02 | 악셀레론 파마 인코포레이티드 | 액티빈-actrⅱa 길항제 및 유방암을 치료 또는 예방하기 위한 이들의 용도 |
TW202104248A (zh) | 2007-02-02 | 2021-02-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
CA2677605C (fr) | 2007-02-09 | 2016-01-19 | Acceleron Pharma Inc. | Antagonistes de l'activine-actriia et utilisations pour la promotion de la croissance osseuse chez les patients cancereux |
JP2010539236A (ja) | 2007-09-18 | 2010-12-16 | アクセルロン ファーマ, インコーポレイテッド | アクチビン−ActRIIa拮抗薬およびFSH分泌を低減または阻害するための使用 |
JP5778576B2 (ja) | 2008-06-26 | 2015-09-16 | アクセルロン ファーマ, インコーポレイテッド | アクチビン−ActRIIaアンタゴニストを投薬する方法および処置される患者をモニターする方法 |
LT3750552T (lt) | 2008-08-14 | 2023-06-26 | Acceleron Pharma Inc. | Gdf gaudyklės |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
EP2387412A4 (fr) | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | Procédés permettant d'augmenter l'adiponectine |
EP3845239A1 (fr) | 2009-06-08 | 2021-07-07 | Acceleron Pharma Inc. | Utilisation de protéines anti-actriib pour l'augmentation d'adipocytes thermogènes |
KR20190090049A (ko) | 2009-06-12 | 2019-07-31 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
WO2011020045A1 (fr) | 2009-08-13 | 2011-02-17 | Acceleron Pharma Inc. | Utilisation combinée de pièges gdf et d'activateurs du récepteur de l'érythropoïétine pour augmenter les taux de globules rouges |
EP3202459B1 (fr) | 2009-09-09 | 2021-04-14 | Acceleron Pharma Inc. | Antagonistes d'actriib et dosage et utilisations de ceux-ci pour traiter l'obésité ou le diabète en régulant le taux de graisse corporelle |
WO2011056896A1 (fr) | 2009-11-03 | 2011-05-12 | Acceleron Pharma Inc. | Procédés de traitement de la stéatose hépatique |
CA2781152A1 (fr) | 2009-11-17 | 2011-05-26 | Acceleron Pharma Inc. | Proteines actriib et variants et utilisations de celles-ci se rapportant a l'induction de l'utrophine pour une therapie de la dystrophie musculaire |
KR20140084211A (ko) | 2011-10-17 | 2014-07-04 | 악셀레론 파마 인코포레이티드 | 효과가 없는 적혈구생성 치료를 위한 방법 및 조성물 |
WO2014066487A2 (fr) | 2012-10-24 | 2014-05-01 | Celgene Corporation | Méthodes de traitement de l'anémie |
WO2014066486A2 (fr) | 2012-10-24 | 2014-05-01 | Celgene Corporation | Biomarqueur utilisable dans le traitement de l'anémie |
RU2018145985A (ru) | 2012-11-02 | 2019-02-18 | Селджин Корпорейшн | Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений |
CA2962197C (fr) | 2014-04-18 | 2023-10-03 | Ravindra Kumar | Methodes pour augmenter les niveaux de globules rouges et traiter la drepanocytose |
MX2016016531A (es) | 2014-06-13 | 2017-04-25 | Acceleron Pharma Inc | Metodos y composiciones para el tratamiento de las ulceras. |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
TWI773117B (zh) | 2014-12-03 | 2022-08-01 | 美商西建公司 | 活化素-actrii拮抗劑及治療貧血之用途 |
MA41119A (fr) | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
TWI762444B (zh) | 2015-05-13 | 2022-05-01 | 美商西建公司 | 使用ACTRII配位體捕捉以治療β-地中海型貧血 |
CA2986432A1 (fr) | 2015-05-20 | 2016-11-24 | Celgene Corporation | Procedes de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii |
EP3370754A4 (fr) | 2015-11-04 | 2019-10-23 | Acceleron Pharma Inc. | Méthodes pour augmenter les taux d'érythrocytes et traiter l'érythropoïèse inefficace |
KR20180096645A (ko) | 2015-11-23 | 2018-08-29 | 악셀레론 파마 인코포레이티드 | 눈 질환의 치료 방법 |
PT3496739T (pt) | 2016-07-15 | 2021-06-21 | Acceleron Pharma Inc | Composições compreendendo polipéptidos actriia para uso no tratamento de hipertensão pulmonar |
FI3490582T3 (fi) | 2016-07-27 | 2024-08-01 | Acceleron Pharma Inc | Koostumuksia käytettäväksi myelofibroosin hoitamisessa |
PT3638243T (pt) | 2017-06-14 | 2024-10-31 | Celgene Corp | Métodos para tratamento da mielofibrose e anemia associadas ao neoplasma mieloproliferativo |
-
2016
- 2016-05-19 CA CA2986432A patent/CA2986432A1/fr active Pending
- 2016-05-19 MA MA042160A patent/MA42160A/fr unknown
- 2016-05-19 JP JP2018512825A patent/JP2018522579A/ja active Pending
- 2016-05-19 US US15/574,897 patent/US10548976B2/en not_active Expired - Fee Related
- 2016-05-19 EP EP16797267.8A patent/EP3298034A4/fr not_active Withdrawn
- 2016-05-19 WO PCT/US2016/033187 patent/WO2016187378A1/fr active Application Filing
- 2016-05-19 CN CN201680042691.9A patent/CN108350057A/zh active Pending
- 2016-05-19 EP EP22201847.5A patent/EP4190805A3/fr not_active Withdrawn
-
2018
- 2018-09-07 HK HK18111575.0A patent/HK1252174A1/zh unknown
-
2019
- 2019-12-11 US US16/711,039 patent/US20200101157A1/en not_active Abandoned
-
2021
- 2021-09-29 JP JP2021158571A patent/JP2022023072A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US10548976B2 (en) | 2020-02-04 |
CN108350057A (zh) | 2018-07-31 |
US20180161426A1 (en) | 2018-06-14 |
EP3298034A4 (fr) | 2019-02-13 |
JP2018522579A (ja) | 2018-08-16 |
WO2016187378A1 (fr) | 2016-11-24 |
JP2022023072A (ja) | 2022-02-07 |
CA2986432A1 (fr) | 2016-11-24 |
EP4190805A3 (fr) | 2023-08-16 |
HK1252174A1 (zh) | 2019-05-17 |
EP4190805A2 (fr) | 2023-06-07 |
EP3298034A1 (fr) | 2018-03-28 |
US20200101157A1 (en) | 2020-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA42160A (fr) | Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii | |
MA43335B1 (fr) | Compositions d'arni de transthyrétine (ttr) et procédés pour les utiliser pour le traitement ou la prévention de maladies associées à ttr | |
MA41013B1 (fr) | Compositions comprenant des souches bactériennes | |
MA40843A (fr) | Compositions d'arni contre le virus de l'hépatite delta et procédés d'utilisation de celles-ci | |
MA40132B1 (fr) | Inhibiteurs macrocycliques des interactions protéine/protéine pd-1/pd-l1 et cd80(b7-1)/pd-li | |
EA201992546A1 (ru) | Средства на основе антител к cd33 | |
MA46836A (fr) | Agents, utilisations et procédés pour le traitement d'une synucléinopathie | |
MA40682A (fr) | Anticorps anti-ox40 et procédés d'utilisation correspondants | |
MA42428B1 (fr) | Anticorps humanisés et à maturation d'affinité dirigés contre fcrh5 et méthodes d'utilisation | |
MA42439A (fr) | Agents, utilisations et procédés pour le traitement d'une synucléinopathie | |
MA51306A (fr) | Compositions et procédés améliorés pour le traitement du déficit en ornithine transcarbamylase | |
MX2018009633A (es) | Inhibidor de indoleamina-2,3-dioxigenasa (ido). | |
MA42811A (fr) | Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue | |
MA35661B1 (fr) | Inhibiteurs de pak pour le traitement de troubles de prolifération cellulaire | |
MA43763B1 (fr) | Protéine f de pré-fusion du vrs soluble et stabilisée pour son utilisation dans la prophylaxie d'une infection vrs | |
MA39248B1 (fr) | Anticorps anti-jagged1 et procédés d'utilisation correspondants | |
MA39094B1 (fr) | Polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers | |
MA38349A1 (fr) | Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3) | |
FR3046610B1 (fr) | Utilisation de 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes pour la securisation | |
MX2023012628A (es) | Metodos y composiciones para deteccion y diagnostico de enfermedades renales y enfermedades periodontales. | |
MA46548A (fr) | Fsh pour le traitement de l'infertilité | |
MA49633A (fr) | Agents, utilisations et procédés de traitement | |
MA38816A (fr) | Sulfamidase modifiée et sa production | |
EA201792677A1 (ru) | Устройство и способ для обработки ила | |
MA42006A1 (fr) | Molécules hybrides |