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MA37445B1 - Lyophilisation d'agent tensioactif pulmonaire liposomal synthétique - Google Patents

Lyophilisation d'agent tensioactif pulmonaire liposomal synthétique

Info

Publication number
MA37445B1
MA37445B1 MA37445A MA37445A MA37445B1 MA 37445 B1 MA37445 B1 MA 37445B1 MA 37445 A MA37445 A MA 37445A MA 37445 A MA37445 A MA 37445A MA 37445 B1 MA37445 B1 MA 37445B1
Authority
MA
Morocco
Prior art keywords
lyophilization
pulmonary surfactant
synthetic
synthetic liposomal
liposomal pulmonary
Prior art date
Application number
MA37445A
Other languages
English (en)
Other versions
MA37445A1 (fr
Inventor
Sergio Cesco-Cancian
Thomas Hoy
Edward H Trappler
Michael S Thomas
Original Assignee
Discovery Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Discovery Lab Inc filed Critical Discovery Lab Inc
Publication of MA37445A1 publication Critical patent/MA37445A1/fr
Publication of MA37445B1 publication Critical patent/MA37445B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne des agents tensioactifs pulmonaires lyophilisés présentant une surface spécifique et une porosité augmentées. Des procédés de préparation des agents tensioactifs pulmonaires lyophilisés sont également décrits.
MA37445A 2012-03-28 2014-10-22 Lyophilisation d'agent tensioactif pulmonaire liposomal synthétique MA37445B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261616827P 2012-03-28 2012-03-28
PCT/US2013/034464 WO2013149074A1 (fr) 2012-03-28 2013-03-28 Lyophilisation d'agent tensioactif pulmonaire liposomal synthétique

Publications (2)

Publication Number Publication Date
MA37445A1 MA37445A1 (fr) 2016-04-29
MA37445B1 true MA37445B1 (fr) 2017-01-31

Family

ID=48096305

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37445A MA37445B1 (fr) 2012-03-28 2014-10-22 Lyophilisation d'agent tensioactif pulmonaire liposomal synthétique

Country Status (35)

Country Link
US (3) US9554999B2 (fr)
EP (2) EP2837377A1 (fr)
JP (1) JP6178402B2 (fr)
KR (1) KR102123129B1 (fr)
CN (1) CN104271118B (fr)
AU (2) AU2013237985B2 (fr)
BR (1) BR112014024057A8 (fr)
CA (1) CA2867649C (fr)
CL (1) CL2014002553A1 (fr)
CO (1) CO7081146A2 (fr)
CR (1) CR20140449A (fr)
CU (1) CU20140116A7 (fr)
CY (1) CY1117380T1 (fr)
DK (1) DK2723323T3 (fr)
EC (1) ECSP14024363A (fr)
ES (1) ES2557805T3 (fr)
HK (3) HK1197174A1 (fr)
HR (1) HRP20151392T1 (fr)
HU (1) HUE026363T2 (fr)
IL (1) IL234688B (fr)
IN (1) IN2014DN08538A (fr)
MA (1) MA37445B1 (fr)
MX (1) MX359654B (fr)
MY (1) MY164868A (fr)
NZ (1) NZ630219A (fr)
PE (1) PE20142302A1 (fr)
PL (1) PL2723323T3 (fr)
PT (1) PT2723323E (fr)
RS (1) RS54513B1 (fr)
RU (1) RU2671500C2 (fr)
SG (1) SG11201405944PA (fr)
SI (1) SI2723323T1 (fr)
SM (1) SMT201500320B (fr)
WO (2) WO2013149074A1 (fr)
ZA (1) ZA201406982B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013149074A1 (fr) * 2012-03-28 2013-10-03 Discovery Laboratories, Inc. Lyophilisation d'agent tensioactif pulmonaire liposomal synthétique
EP3222273B1 (fr) * 2014-11-18 2019-09-25 National Institute for Materials Science Procédé de fabrication de particule poreuse
WO2016108534A1 (fr) * 2014-12-30 2016-07-07 주식회사 삼양바이오팜 Produit lyophilisé de nanoparticules de polymère, et son procédé de préparation
PL3319597T3 (pl) * 2015-07-10 2021-10-11 Byondis B.V. Kompozycje zawierające koniugaty przeciwciało-duokarmycyna
HUE053990T2 (hu) 2015-07-22 2021-08-30 Nitto Denko Corp Nanorészecske liofilizált formák készítményei és eljárások
JP7012512B2 (ja) * 2017-11-13 2022-01-28 清水建設株式会社 管理装置、製造システムおよび管理方法
AU2018392461B2 (en) * 2017-12-21 2024-10-31 Civitas Therapeutics, Inc. Surfactant formulations for inhalation
CN108853061A (zh) * 2018-10-09 2018-11-23 兆科药业（合肥）有限公司 一种人工合成肺表面活性剂药物组合物及与之的肠溶胶囊和其制备方法及用途
WO2020142420A1 (fr) * 2018-12-31 2020-07-09 Novus Therapeutics, Inc. Nouvelle substance médicamenteuse à base d'alliage de tensioactif-lipide, ses procédés de production et compositions pharmaceutiques la comprenant
US11287185B1 (en) 2020-09-09 2022-03-29 Stay Fresh Technology, LLC Freeze drying with constant-pressure and constant-temperature phases
KR102545292B1 (ko) * 2021-01-28 2023-06-16 인천대학교 산학협력단 마이크로캡슐 형성용 생체 적합 계면활성제 합성방법
TW202317609A (zh) * 2021-07-05 2023-05-01 義大利商吉斯藥品公司 肺部表面張力素之製備方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE751108R (fr) 1969-06-06 1970-11-03 Berliet Automobiles Dispositif pour la mesure precise de la consommation specifiquedes moteurs a combustion
JPS59164724A (ja) * 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
ATE212220T1 (de) 1996-01-24 2002-02-15 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von pulverförmigen lungensurfactant-zubereitungen
WO1997035882A1 (fr) * 1996-03-27 1997-10-02 Ortho Pharmaceutical Corporation Compositions lyophilisees de peptides tensioactifs pulmonaires
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
JPWO2005105111A1 (ja) 2004-04-29 2008-07-31 相男 李 人工肺サーファクタント組成物およびその使用方法
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
EP1912667B1 (fr) * 2005-07-22 2012-08-29 Amgen Inc. Lyophilisats proteiques concentres, procedes associes et leurs utilisations
EP1997502A1 (fr) 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Agents tensioactifs reconstitués dotés de propriétés améliorées
WO2013149074A1 (fr) * 2012-03-28 2013-10-03 Discovery Laboratories, Inc. Lyophilisation d'agent tensioactif pulmonaire liposomal synthétique

Also Published As

Publication number Publication date
EP2837377A1 (fr) 2015-02-18
RU2014143247A (ru) 2016-05-20
EP2723323A1 (fr) 2014-04-30
MX359654B (es) 2018-10-05
US20150297524A1 (en) 2015-10-22
IL234688A0 (en) 2014-11-30
CR20140449A (es) 2015-05-04
CO7081146A2 (es) 2014-10-10
CN104271118A (zh) 2015-01-07
HK1197174A1 (zh) 2015-01-09
JP6178402B2 (ja) 2017-08-09
US8748397B2 (en) 2014-06-10
CL2014002553A1 (es) 2015-04-06
ES2557805T3 (es) 2016-01-28
RU2671500C2 (ru) 2018-11-01
MA37445A1 (fr) 2016-04-29
CY1117380T1 (el) 2017-04-26
HRP20151392T1 (hr) 2016-03-25
MY164868A (en) 2018-01-30
CA2867649C (fr) 2021-02-16
PT2723323E (pt) 2016-01-27
NZ630219A (en) 2016-09-30
IL234688B (en) 2020-01-30
US20140088025A1 (en) 2014-03-27
IN2014DN08538A (fr) 2015-05-15
AU2017239624A1 (en) 2017-10-26
AU2013237985B2 (en) 2017-07-06
WO2013149074A1 (fr) 2013-10-03
RS54513B1 (en) 2016-06-30
BR112014024057A2 (fr) 2017-06-20
SG11201405944PA (en) 2014-10-30
HK1206979A1 (en) 2016-01-22
US20140088026A1 (en) 2014-03-27
DK2723323T3 (en) 2016-01-11
MX2014011483A (es) 2014-12-08
JP2015514714A (ja) 2015-05-21
SMT201500320B (it) 2016-02-25
KR102123129B1 (ko) 2020-06-15
HK1205685A1 (en) 2015-12-24
PE20142302A1 (es) 2015-01-21
ZA201406982B (en) 2016-05-25
KR20140137453A (ko) 2014-12-02
CA2867649A1 (fr) 2013-10-03
EP2723323B1 (fr) 2015-09-23
HUE026363T2 (en) 2016-06-28
US9554999B2 (en) 2017-01-31
ECSP14024363A (es) 2015-09-30
CN104271118B (zh) 2017-02-08
BR112014024057A8 (pt) 2018-01-16
AU2013237985A1 (en) 2014-10-02
US8748396B2 (en) 2014-06-10
AU2017239624B2 (en) 2017-11-23
SI2723323T1 (sl) 2016-04-29
PL2723323T3 (pl) 2016-05-31
CU20140116A7 (es) 2015-01-29
WO2013149013A1 (fr) 2013-10-03

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