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MA34389B1 - Nouvelles aminopyrazoloquinazolines - Google Patents

Nouvelles aminopyrazoloquinazolines

Info

Publication number
MA34389B1
MA34389B1 MA35577A MA35577A MA34389B1 MA 34389 B1 MA34389 B1 MA 34389B1 MA 35577 A MA35577 A MA 35577A MA 35577 A MA35577 A MA 35577A MA 34389 B1 MA34389 B1 MA 34389B1
Authority
MA
Morocco
Prior art keywords
aminopyrazoloquinazolines
new
groups
general formula
present
Prior art date
Application number
MA35577A
Other languages
English (en)
Inventor
Matthias Treu
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43037625&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34389(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA34389B1 publication Critical patent/MA34389B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention englobe les composés de formule générale (I) où les groupements R
MA35577A 2010-07-23 2011-07-22 Nouvelles aminopyrazoloquinazolines MA34389B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10170683 2010-07-23
PCT/EP2011/062683 WO2012010704A1 (fr) 2010-07-23 2011-07-22 Nouvelles aminopyrazoloquinazolines

Publications (1)

Publication Number Publication Date
MA34389B1 true MA34389B1 (fr) 2013-07-03

Family

ID=43037625

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35577A MA34389B1 (fr) 2010-07-23 2011-07-22 Nouvelles aminopyrazoloquinazolines

Country Status (22)

Country Link
US (1) US8735386B2 (fr)
EP (1) EP2595987B1 (fr)
JP (1) JP5991974B2 (fr)
KR (1) KR20130132394A (fr)
CN (1) CN103097388A (fr)
AP (1) AP2012006640A0 (fr)
AR (1) AR082850A1 (fr)
AU (1) AU2011281504A1 (fr)
BR (1) BR112013000107A2 (fr)
CA (1) CA2803467A1 (fr)
CL (1) CL2012003745A1 (fr)
CO (1) CO6670575A2 (fr)
EA (1) EA201201661A1 (fr)
EC (1) ECSP13012448A (fr)
GE (1) GEP20156289B (fr)
MA (1) MA34389B1 (fr)
MX (1) MX2013000821A (fr)
PE (1) PE20131143A1 (fr)
SG (1) SG187548A1 (fr)
TW (1) TW201217380A (fr)
UY (1) UY33526A (fr)
WO (1) WO2012010704A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2807166B1 (fr) * 2012-01-23 2016-04-06 Boehringer Ingelheim International GmbH 5,8-dihydro-6h-pyrazolo[3,4-h]quinazolines en tant qu'inhibiteurs igf-1r/ir
US9376437B2 (en) 2013-03-13 2016-06-28 Oncoceutics, Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
ES2724331T3 (es) * 2013-11-15 2019-09-10 Oncoceutics Inc 7-Bencil-4-(2-metilbencil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1H)-ona, sales de la misma y procedimientos de uso
MA41434B1 (fr) 2015-01-30 2021-03-31 Oncoceutics Inc 7-benzyl-4-(4-(trifluorométhyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one, ses sels et leur utilisation en thérapie
JP6664414B2 (ja) * 2015-05-13 2020-03-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ＩＧＦ−１Ｒ／ＩＲ阻害薬としての新規５，８−ジメチル−９−フェニル−５，８−ジヒドロ−６Ｈ−ピラゾロ［３，４−ｈ］キナゾリン−２−イル）−（１Ｈ−ピラゾール−３−イル）−アミン及び誘導体
CA3039012C (fr) * 2016-11-11 2021-08-24 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Composes heterotricyclo a substitution par pyridinamine, leur preparation et leur utilisation dans des medicaments
WO2018214961A1 (fr) * 2017-05-26 2018-11-29 江苏新元素医药科技有限公司 Inhibiteur de l'urat1 stimulant l'excrétion urinaire
CN107383019B (zh) * 2017-07-28 2019-10-15 江苏艾凡生物医药有限公司 吡唑并[4,3-h]喹唑啉类化合物及其用途
EP3786161A4 (fr) * 2018-04-24 2021-05-05 Shanghai Haiyan Pharmaceutical Technology Co., Ltd Inhibiteur de cdk4/6, sel pharmaceutiquement acceptable, polymorphe de celui-ci et utilisation associée
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
EP3917514A4 (fr) * 2019-01-30 2023-02-22 Yale University Composés, compositions et méthodes de traitement de la fibrose
US11384083B2 (en) 2019-02-15 2022-07-12 Incyte Corporation Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
WO2020180959A1 (fr) 2019-03-05 2020-09-10 Incyte Corporation Composés de pyrazolyl pyrimidinylamine en tant qu'inhibiteurs de cdk2
DK3935047T3 (da) * 2019-03-07 2024-09-09 BioNTech SE Fremgangsmåde til fremstilling af et substitueret imidazoquinolin
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
EP3955887A1 (fr) * 2019-04-19 2022-02-23 Fount Bio, Inc. Administration et rétention d'agents actifs dans la peau
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2020223469A1 (fr) 2019-05-01 2020-11-05 Incyte Corporation Dérivés de n-(1-(méthylsulfonyl)pipéridin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine et composés apparentés utilisés en tant qu'inhibiteurs de kinase 2 dépendante des cyclines (cdk2) pour le traitement du cancer
CN116348458A (zh) 2019-08-14 2023-06-27 因赛特公司 作为cdk2抑制剂的咪唑基嘧啶基胺化合物
AR120184A1 (es) 2019-10-11 2022-02-02 Incyte Corp Aminas bicíclicas como inhibidoras de la cdk2
WO2021247969A1 (fr) 2020-06-05 2021-12-09 Kinnate Biopharma Inc. Inhibiteurs des kinases réceptrices du facteur de croissance des fibroblastes
CN111960974A (zh) * 2020-08-28 2020-11-20 山东潍坊润丰化工股份有限公司 一种烯草酮中间体的合成方法
JP7545622B2 (ja) * 2021-02-08 2024-09-05 江蘇星盛新輝医薬有限公司 ５，６－ジドヒロチエノ［３，４－ｈ］キナゾリン系化合物
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2233003A1 (fr) * 1995-10-02 1997-04-10 F. Hoffmann-La Roche Ag Derives de pyrimidine en tant qu'antagonistes du recepteur de 5ht2c
SI1636236T1 (sl) 2003-05-22 2014-01-31 Nerviano Medical Sciences S.R.L. Pirazolo-kinazolinski derivati, postopek za njihovo pripravo in njihova uporaba kot kinazni inhibitorji
CN1897950A (zh) 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法

Also Published As

Publication number Publication date
SG187548A1 (en) 2013-03-28
JP5991974B2 (ja) 2016-09-14
AU2011281504A1 (en) 2013-01-10
KR20130132394A (ko) 2013-12-04
CA2803467A1 (fr) 2012-01-26
TW201217380A (en) 2012-05-01
EP2595987A1 (fr) 2013-05-29
US8735386B2 (en) 2014-05-27
GEP20156289B (en) 2015-05-25
JP2013532652A (ja) 2013-08-19
US20120238542A1 (en) 2012-09-20
PE20131143A1 (es) 2013-10-23
ECSP13012448A (es) 2013-03-28
AP2012006640A0 (en) 2012-12-31
BR112013000107A2 (pt) 2016-05-17
EP2595987B1 (fr) 2018-04-18
CL2012003745A1 (es) 2013-05-31
MX2013000821A (es) 2013-05-30
CN103097388A (zh) 2013-05-08
UY33526A (es) 2012-02-29
CO6670575A2 (es) 2013-05-15
AR082850A1 (es) 2013-01-16
WO2012010704A1 (fr) 2012-01-26
EA201201661A1 (ru) 2013-07-30

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