MA23717A1 - Nouveaux derives de (3-(4-phenyl piperazine-1-yl) - propylamino) - pyridine de pyrimidine, et de benzene, servant d'antagonistes des adrenorecepteurs a1, leur utilisation comme agents therapeutiques, et procede pour leur preparation - Google Patents

Nouveaux derives de (3-(4-phenyl piperazine-1-yl) - propylamino) - pyridine de pyrimidine, et de benzene, servant d'antagonistes des adrenorecepteurs a1, leur utilisation comme agents therapeutiques, et procede pour leur preparation

Info

Publication number: MA23717A1
Authority: MA; Morocco
Prior art keywords: antiagonists; adrenorepeptors; propylamino; benzene; preparation
Prior art date: 1994-11-08

Application number

MA24062A

Other languages

English (en)

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-08

Filing date

1995-11-08

Publication date

1996-07-01

1995-11-08 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1996-07-01 Publication of MA23717A1 publication Critical patent/MA23717A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

MA24062A 1994-11-08 1995-11-08 Nouveaux derives de (3-(4-phenyl piperazine-1-yl) - propylamino) - pyridine de pyrimidine, et de benzene, servant d'antagonistes des adrenorecepteurs a1, leur utilisation comme agents therapeutiques, et procede pour leur preparation MA23717A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/336,368 US5688795A (en)	1994-11-08	1994-11-08	3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists

Publications (1)

Publication Number	Publication Date
MA23717A1 true MA23717A1 (fr)	1996-07-01

Family

ID=23315765

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA24062A MA23717A1 (fr)	1994-11-08	1995-11-08	Nouveaux derives de (3-(4-phenyl piperazine-1-yl) - propylamino) - pyridine de pyrimidine, et de benzene, servant d'antagonistes des adrenorecepteurs a1, leur utilisation comme agents therapeutiques, et procede pour leur preparation

Country Status (22)

Country	Link
US (1)	US5688795A (fr)
EP (1)	EP0711757A1 (fr)
JP (1)	JPH08208614A (fr)
KR (1)	KR960017658A (fr)
CN (1)	CN1136039A (fr)
AR (1)	AR002244A1 (fr)
AU (1)	AU3459995A (fr)
BR (1)	BR9505107A (fr)
CA (1)	CA2162089A1 (fr)
CO (1)	CO4520230A1 (fr)
CZ (1)	CZ291095A3 (fr)
FI (1)	FI955376A (fr)
HU (1)	HUT73843A (fr)
IL (1)	IL115844A0 (fr)
MA (1)	MA23717A1 (fr)
NO (1)	NO954453L (fr)
NZ (1)	NZ280396A (fr)
PE (1)	PE10997A1 (fr)
PL (1)	PL311261A1 (fr)
SG (1)	SG70950A1 (fr)
TR (1)	TR199501387A2 (fr)
ZA (1)	ZA959268B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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DE4425143A1 (de)	1994-07-15	1996-01-18	Basf Ag	Substituierte Pyrimidinverbindungen und deren Verwendung
CN1269807C (zh) *	1997-05-12	2006-08-16	奥索-麦克尼尔药品公司	可用于治疗良性前列腺肥大的芳基取代哌嗪
DE19728996A1 (de)	1997-07-07	1999-01-14	Basf Ag	Triazolverbindungen und deren Verwendung
US6399614B1 (en)	1997-08-01	2002-06-04	Recordati S.A. Chemical And Pharmaceutical Company	1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
US6271234B1 (en)	1997-08-01	2001-08-07	Recordati S.A., Chemical And Pharmaceutical Company	1,4-disubstituted piperazines
US20020193383A1 (en) *	1997-08-01	2002-12-19	Recordati S.A., Chemical And Pharmaceutical Comoany	1-(N-phenylalkylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
IT1293807B1 (it) *	1997-08-01	1999-03-10	Recordati Chem Pharm	Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
IT1293804B1 (it)	1997-08-01	1999-03-10	Recordati Chem Pharm	Diarilalchilpiperazine attive sulle basse vie urinarie
ZA991315B (en)	1998-02-20	2000-11-20	Ortho Mcneil Pharm Inc	Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia.
US6489344B1 (en)	1998-06-19	2002-12-03	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
US7045519B2 (en) *	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
US6465467B1 (en)	1999-05-21	2002-10-15	Biovitrum Ab	Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
US6355801B1 (en) *	1999-11-08	2002-03-12	Schering Corporation	Process for preparing N-(4-hydroxyphenyl)-N′-(4′-aminophenyl)-piperazine
WO2002040457A1 (fr)	2000-11-20	2002-05-23	Biovitrum Ab	Composes de piperazinylpyrazines utilises comme antagonistes du recepteur de la serotonine 5-ht2
WO2002044151A1 (fr)	2000-11-30	2002-06-06	Ranbaxy Laboratories Limited	Derives de piperazine 1,4-disubstitues utiles comme bloqueurs uroselectifs des recepteurs alpha1-adrenergiques
WO2004000830A1 (fr)	2002-06-19	2003-12-31	Biovitrum Ab	Nouveaux composes, leur utilisation et leur preparation
UA89035C2 (ru) *	2003-12-03	2009-12-25	Лео Фарма А/С	Эфиры гидроксамовых кислот и их фармацевтическое применение
MY140489A (en) *	2003-12-26	2009-12-31	Eisai R&D Man Co Ltd	1,2-di (cyclic) substituted benzene compounds
WO2005112538A2 (fr) *	2004-05-20	2005-12-01	Universidade Federal Do Rio De Janeiro-Ufrj	Utilisation d'antagonistes de n-phenylpiperazine adrenergiques, compositions pharmaceutiques les contenant et leurs procedes de preparation
EP2077262A4 (fr) *	2006-10-23	2011-12-28	Takeda Pharmaceutical	Dérivé de l'iminopyridine et son utilisation
JP5441705B2 (ja) *	2007-10-15	2014-03-12	武田薬品工業株式会社	アミド化合物およびその用途
US20110039892A1 (en) *	2008-04-23	2011-02-17	Takeda Pharmaceutical Company Limited	Iminopyridine derivative and use thereof
AR071392A1 (es) *	2008-04-23	2010-06-16	Takeda Pharmaceutical	Derivados de iminopiridina y su uso
US8481569B2 (en)	2008-04-23	2013-07-09	Takeda Pharmaceutical Company Limited	Iminopyridine derivatives and use thereof
CN101585781B (zh) *	2009-07-08	2012-08-08	北京颖新泰康国际贸易有限公司	一种邻氨基-n,n-二甲基苯甲酰胺的制备方法
CN103387531A (zh) *	2012-05-10	2013-11-13	广州医学院	酰胺类芳基哌嗪衍生物及其制备方法和在抗良性前列腺增生中的应用
CN114163383A (zh) *	2021-12-24	2022-03-11	江苏丰山集团股份有限公司	一种烟嘧磺隆中间体烟酰胺和磺酰胺的绿色生产工艺
CN115611802B (zh) *	2022-12-02	2023-03-14	北京迪泰医药科技有限公司	一种3-乙酰基-2-氯吡啶的合成方法

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US3635976A (en) *	1967-12-20	1972-01-18	Pennwalt Corp	1 - heterocyclic alkyl-1 2 3 4-tetrahydroquinazolinones and analgesic intermediates thereof
BE787126A (fr) *	1971-08-04	1973-02-05	Byk Gulden Lomberg Chem Fab	Pyrimidines substituees, procedes de preparation de ces composes et medicaments contenant lesdits composes
DE2143730A1 (de) *	1971-09-01	1973-03-08	Byk Gulden Lomberg Chem Fab	Substituierte pyridine, verfahren zu deren herstellung und sie enthaltende arzneimittel
JPS49133380A (fr) *	1973-04-25	1974-12-21
US4616017A (en) *	1984-06-04	1986-10-07	Merck & Co., Inc.	Aminohydroxypropoxy substituted aryl compounds
GB2163150B (en) *	1984-07-19	1988-05-25	Sandoz Ltd	3-aminopropoxyaryl derivatives
FR2656609B1 (fr) *	1989-12-28	1992-03-27	Synthelabo	Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678272B1 (fr) *	1991-06-27	1994-01-14	Synthelabo	Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

1994
- 1994-11-08 US US08/336,368 patent/US5688795A/en not_active Expired - Fee Related
1995
- 1995-10-27 EP EP95116942A patent/EP0711757A1/fr not_active Withdrawn
- 1995-11-01 SG SG1995001704A patent/SG70950A1/en unknown
- 1995-11-01 IL IL11584495A patent/IL115844A0/xx unknown
- 1995-11-01 AU AU34599/95A patent/AU3459995A/en not_active Abandoned
- 1995-11-02 ZA ZA9509268A patent/ZA959268B/xx unknown
- 1995-11-03 NZ NZ280396A patent/NZ280396A/en unknown
- 1995-11-03 CA CA002162089A patent/CA2162089A1/fr not_active Abandoned
- 1995-11-06 PE PE1995283893A patent/PE10997A1/es not_active Application Discontinuation
- 1995-11-06 HU HU9503178A patent/HUT73843A/hu unknown
- 1995-11-06 CN CN95118772A patent/CN1136039A/zh active Pending
- 1995-11-06 AR ARP950100065A patent/AR002244A1/es unknown
- 1995-11-07 BR BR9505107A patent/BR9505107A/pt not_active Application Discontinuation
- 1995-11-07 PL PL95311261A patent/PL311261A1/xx unknown
- 1995-11-07 CZ CZ952910A patent/CZ291095A3/cs unknown
- 1995-11-07 CO CO95052482A patent/CO4520230A1/es unknown
- 1995-11-07 NO NO954453A patent/NO954453L/no unknown
- 1995-11-07 JP JP7287753A patent/JPH08208614A/ja active Pending
- 1995-11-08 TR TR95/01387A patent/TR199501387A2/xx unknown
- 1995-11-08 FI FI955376A patent/FI955376A/fi unknown
- 1995-11-08 KR KR1019950040349A patent/KR960017658A/ko not_active Application Discontinuation
- 1995-11-08 MA MA24062A patent/MA23717A1/fr unknown

Also Published As

Publication number	Publication date
EP0711757A1 (fr)	1996-05-15
ZA959268B (en)	1997-01-31
CN1136039A (zh)	1996-11-20
FI955376A (fi)	1996-05-09
PE10997A1 (es)	1997-04-26
PL311261A1 (en)	1996-05-13
HUT73843A (en)	1996-09-30
KR960017658A (ko)	1996-06-17
IL115844A0 (en)	1996-01-31
NZ280396A (en)	1997-05-26
AU3459995A (en)	1996-05-16
US5688795A (en)	1997-11-18
SG70950A1 (en)	2000-03-21
AR002244A1 (es)	1998-03-11
TR199501387A2 (tr)	1996-07-21
HU9503178D0 (en)	1996-01-29
FI955376A0 (fi)	1995-11-08
BR9505107A (pt)	1997-09-09
NO954453L (no)	1996-05-09
CZ291095A3 (en)	1996-09-11
CO4520230A1 (es)	1997-10-15
NO954453D0 (no)	1995-11-07
JPH08208614A (ja)	1996-08-13
CA2162089A1 (fr)	1996-05-09

Publication	Publication Date	Title
MA23717A1 (fr)	1996-07-01	Nouveaux derives de (3-(4-phenyl piperazine-1-yl) - propylamino) - pyridine de pyrimidine, et de benzene, servant d'antagonistes des adrenorecepteurs a1, leur utilisation comme agents therapeutiques, et procede pour leur preparation
MA25493A1 (fr)	2002-07-01	Derives de 3(5)-amino-pyrazole, procede pour leur preparation et leur utilisation en tant qu'agents antitumoraux.
MA23831A1 (fr)	1996-10-01	Derives de quinazoline, procede pour leur preparation et composition les contenant
MA24484A1 (fr)	1998-10-01	Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenant .
MA24469A1 (fr)	1998-10-01	Derives d'acide arylsulfonyhydroxamique, procede pour leur preparation et compositions les contenant
MA26479A1 (fr)	2004-12-20	Derives de nicotinamide, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26430A1 (fr)	2004-12-20	4 (3h)-quinazolinones 2,3-disubstituees nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26432A1 (fr)	2004-12-20	Derives de 2-(2-oxo-ethylidene)-imidazolidine-4-one, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2740136B1 (fr)	1998-01-09	Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
MA23899A1 (fr)	1996-12-31	Procede pour la preparation de derives de pyrimidinedione et -trione, triazinedione et quinazolinedione, procede de preparation de compositions pharmaceutiques les contenant et leur utilisation
MA26439A1 (fr)	2004-12-20	Derives d'indazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
HUP9701096A3 (en)	2000-08-28	Use of benzenesulfonamides for the preparation of pharmaceutical compositions treating disorders of the central nervous system, novel derivatives, process for their preparation and pharmaceutical compositions containing them
MA26536A1 (fr)	2004-12-20	Association de compositions pharmaceutiques d'atorvastatine et d'agents antihypertensifs, et procede pour leur preparation.
DZ2045A1 (fr)	2002-07-21	Amides thérapeutiques, procédé pour leur préparation et compositions les contenant.
EE200100252A (et)	2002-10-15	Pürimidiinderivaadid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja sellevalmistamismeetod, kombinatsioon ning saadus
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