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Bobbitt et al., 2025 - Google Patents

Targeting the mitotic kinase NEK2 enhances CDK4/6 inhibitor efficacy by potentiating genome instability

Bobbitt et al., 2025

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Document ID
3734895821487240846
Author
Bobbitt J
Cuellar-Vite L
Weber-Bonk K
Yancey M
Majmudar P
Keri R
Publication year
Publication venue
Journal of Biological Chemistry

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Snippet

Selective inhibitors that target cyclin-dependent kinases 4 and 6 (CDK4/6i) are approved by the US Food and Drug Administration (FDA) for treatment of a subset of breast cancers and are being evaluated in numerous clinical trials for other cancers. Despite this advance, a …
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