Kim et al., 2012 - Google Patents
ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4Kim et al., 2012
View PDF- Document ID
- 3614834094962974065
- Author
- Kim M
- Kim S
- Cho Y
- Nadas J
- Jeong C
- Yao K
- Kim D
- Yu D
- Keum Y
- Lee K
- Huang Z
- Bode A
- Dong Z
- Publication year
- Publication venue
- Nature structural & molecular biology
External Links
Snippet
Understanding and controlling the mechanism by which stem cells balance self-renewal versus differentiation is of great importance for stem cell therapeutics. Klf4 promotes the self- renewal of embryonic stem cells, but the precise mechanism regulating this role of Klf4 is …
- 102100006525 KLF4 0 title abstract description 226
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- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
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- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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