[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Koehbach et al., 2016 - Google Patents

MALDI TOF/TOF-based approach for the identification of D-amino acids in biologically active peptides and proteins

Koehbach et al., 2016

View PDF
Document ID
347015699684332322
Author
Koehbach J
Gruber C
Becker C
Kreil D
Jilek A
Publication year
Publication venue
Journal of Proteome Research

External Links

Snippet

Several biologically active peptides contain a d-amino acid in a well-defined position, which is position 2 in all peptide epimers isolated to date from vertebrates and also some from invertebrates. The detection of such d-residues by standard analytical techniques is …
Continue reading at pubs.acs.org (PDF) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes

Similar Documents

Publication Publication Date Title
Koehbach et al. MALDI TOF/TOF-based approach for the identification of D-amino acids in biologically active peptides and proteins
Bai et al. Distinguishing endogenous D-amino acid-containing neuropeptides in individual neurons using tandem mass spectrometry
JP5576610B2 (en) Peptide structure library construction and screening method
Tao et al. Discriminating D-amino acid-containing peptide epimers by radical-directed dissociation mass spectrometry
Jia et al. Site-specific characterization of D-amino acid containing peptide epimers by ion mobility spectrometry
Hedtke et al. A comprehensive map of human elastin cross‐linking during elastogenesis
Liu et al. De novo protein sequencing by combining top-down and bottom-up tandem mass spectra
Kawakami et al. Peptide bond formation mediated by 4, 5-dimethoxy-2-mercaptobenzylamine after periodate oxidation of the N-terminal serine residue
Bai et al. Analysis of endogenous D-amino acid-containing peptides in metazoa
Mehaffey et al. Multistage ultraviolet photodissociation mass spectrometry to characterize single amino acid variants of human mitochondrial BCAT2
Mast et al. Differential post-translational amino acid isomerization found among neuropeptides in Aplysia californica
Haußmann et al. Analysis of amino-terminal variants of amyloid-β peptides by capillary isoelectric focusing immunoassay
Leymarie et al. Tandem mass spectrometry for structural characterization of proline-rich proteins: application to salivary PRP-3
Sargaeva et al. Differentiating N-terminal aspartic and isoaspartic acid residues in peptides
Ewing et al. Detecting D-amino acid-containing neuropeptides using selective enzymatic digestion
Liu et al. Positive enrichment of C-terminal peptides using oxazolone chemistry and biotinylation
Sui et al. Proteomics of neuropathic pain: proteins and signaling pathways affected in a rat model
Hu et al. Lysarginase and chemical derivatization based strategy for facilitating in-depth profiling of C-terminome
Silzel et al. PIMT-mediated labeling of l-isoaspartic acid with Tris facilitates identification of isomerization sites in long-lived proteins
Robinson et al. Integrating weak anion exchange and ultraviolet photodissociation mass spectrometry with strategic modulation of peptide basicity for the enrichment of sulfopeptides
Sachon et al. D-amino acid detection in peptides by MALDI-TOF-TOF
Ma et al. Large-scale differentiation and site specific discrimination of hydroxyproline isomers by electron transfer/higher-energy collision dissociation (EThcD) mass spectrometry
Wang et al. Releasing nonperipheral subunits from protein complexes in the gas phase
Ruse et al. Polyglutamylation: biology and analysis
Artemenko et al. Two dimensional mass mapping as a general method of data representation in comprehensive analysis of complex molecular mixtures