[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Sache et al., 1989 - Google Patents

Partially N-desulfated heparin as a non-anticoagulant heparin: some physico-chemical and biological properties

Sache et al., 1989

Document ID
3305872510051851511
Author
Sache E
Maillard M
Malazzi P
Bertrand H
Publication year
Publication venue
Thrombosis research

External Links

Snippet

A partially N-desulfated preparation of heparin (UFH) obtained by thermally inactivating heparinic acid for 24 hours at 50° C (TIHA) was examined for its physico-chemical and biological properties in vitro and in vivo. TIHA has a molecular weight of 14,700 and 27 …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Similar Documents

Publication Publication Date Title
CA1171375A (en) Oligosaccharides having selective anticoagulation activity
Holmer et al. Anticoagulant activities and effects on platelets of a heparin fragment with high affinity for antithrombin
EP0983304B1 (en) Dermatan disulfate, an inhibitor of thrombin generation and complement activation
US4533549A (en) Antithrombotic agent
Walenga et al. The inhibition of the generation of thrombin and the antithrombotic effect of a pentasaccharide with sole anti-factor Xa activity
JPH06506685A (en) Novel non-anticoagulant heparin derivative
NZ214094A (en) Xylan sulphates of low molecular weight, process for their preparation and medicaments containing them
Merton et al. Experimental studies on the relative efficacy of dermatan sulphate and heparin as antithrombotic agents
Maggi et al. Antithrombotic properties of dermatan sulphate in a rat venous thrombosis model
Walenga et al. Intravenous antithrombotic activity of a synthetic heparin pentasaccharide in a human serum induced stasis thrombosis model
Westwick et al. Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro
JPH0323528B2 (en)
Walenga et al. Importance of a 3-0-sulfate group in a heparin pentasaccharide for antithrombotic activity
Godal The interaction of protamine with human fibrinogen and the significance of this interaction for the coagulation of fibrinogen
JPH03243601A (en) Mucopolysaccharide composition having ability to control blood coagulation and preparation thereof
Dawes Measurement of the affinities of heparins, naturally occurring glycosaminoglycans, and other sulfated polymers for antithrombin III and thrombin
Gao et al. Sodium alginate/heparin composites on PVC surfaces inhibit the thrombosis and platelet adhesion: applications in cardiac surgery
Sache et al. Partially N-desulfated heparin as a non-anticoagulant heparin: some physico-chemical and biological properties
Bianchini et al. Lack of correlation between “in vitro” and “in vivo” antithrombotic activity of heparin fractions and related compounds. Heparan sulfate as an antithrombotic agent “in vivo”
O’Brien Anti-thrombin III and heparin clotting times in thrombosis and atherosclerosis
Dol et al. Effects of increased sulfation of dermatan sulfate on its in vitro and in vivo pharmacological properties
Hoppensteadt et al. Comparative antithrombotic and hemorrhagic effects of dermatan sulfate, heparin sulfate and heparin
Barrowcliffe et al. Heparin and bleeding: an association with lipase release
Johnson Heparan sulphates from porcine intestinal mucosa. Preparation and physicochemical properties
Raake et al. Anticoagulant and antithrombotic properties of synthetic sulfated bis-lactobionic acid amides