Gonçalves et al., 2001 - Google Patents
Synthesis, Characterization, and Comparative 32P-Postlabeling Efficiencies of 2, 6-Dimethylaniline− DNA AdductsGonçalves et al., 2001
- Document ID
- 3240599762628660929
- Author
- Gonçalves L
- Beland F
- Marques M
- Publication year
- Publication venue
- Chemical Research in Toxicology
External Links
Snippet
2, 6-Dimethylaniline (2, 6-diMeA) is a ubiquitous environmental pollutant that is used in industry as a synthetic intermediate. It is also found in tobacco smoke and as a major metabolite of lidocaine. Although the potential carcinogenicity of 2, 6-diMeA in humans is …
- 108020005124 DNA Adducts 0 title abstract description 116
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Nohynek et al. | Under the skin: biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes | |
Gao et al. | Selective detection of superoxide anion radicals generated from macrophages by using a novel fluorescent probe | |
Beland et al. | Synthesis, characterization, and quantitation of a 4-aminobiphenyl− DNA adduct standard | |
Nonaka et al. | Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction | |
Zhu et al. | 4-nitrobenzyloxycarbonyl derivatives of O 6-benzylguanine as hypoxia-activated prodrug inhibitors of O 6-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the o-6 position of DNA guanine | |
Marques et al. | Effect of Substitution Site upon the Oxidation Potentials of Alkylanilines, the Mutagenicities of N-Hydroxyalkylanilines, and the Conformations of Alkylaniline− DNA Adducts | |
Gonçalves et al. | Synthesis, Characterization, and Comparative 32P-Postlabeling Efficiencies of 2, 6-Dimethylaniline− DNA Adducts | |
Mishanina et al. | Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase | |
Marques et al. | Synthesis, characterization, and conformational analysis of DNA adducts from methylated anilines present in tobacco smoke | |
Barbosa et al. | " Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites | |
Mutlib et al. | Alternate strategies to obtain mass balance without the use of radiolabeled compounds: application of quantitative fluorine (19F) nuclear magnetic resonance (NMR) spectroscopy in metabolism studies | |
LaFrancois et al. | Synthesis and characterization of isotopically enriched pyrimidine deoxynucleoside oxidation damage products | |
Müller et al. | Analysis of 1, N 2-ethenoguanine and 5, 6, 7, 9-tetrahydro-7-hydroxy-9-oxoimidazo [1, 2-a] purine in DNA treated with 2-chlorooxirane by high performance liquid chromatography/electrospray mass spectrometry and comparison of amounts to other DNA adducts | |
Ricicki et al. | Detection and quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human pancreas tissue using capillary liquid chromatography-microelectrospray mass spectrometry | |
NicDaéid et al. | Using isotopic fractionation to link precursor to product in the synthesis of (±)-mephedrone: a new tool for combating “legal high” drugs | |
Boppy et al. | Stability‐indicating liquid chromatography method development for assay and impurity profiling of amitriptyline hydrochloride in tablet dosage form and forced degradation study | |
Guengerich et al. | Formation and reactions of N 7-aminoguanosine and derivatives | |
Wang et al. | Metabolism and disposition of aditoprim in swine, broilers, carp and rats | |
Cui et al. | Identification of adducts formed by reaction of N-acetoxy-3, 5-dimethylaniline with DNA | |
Schütze et al. | Synthesis and quantification of DNA adducts of 4, 4 ‘-methylenedianiline | |
Nakagawa et al. | Cytotoxic effects of psychotropic benzofuran derivatives, N‐methyl‐5‐(2‐aminopropyl) benzofuran and its N‐demethylated derivative, on isolated rat hepatocytes | |
Kasprzyk et al. | Direct High‐Throughput Screening Assay for mRNA Cap Guanine‐N7 Methyltransferase Activity | |
Bai et al. | Quantification of meCCNU‐induced dG‐dC crosslinks in oligonucleotide duplexes by liquid chromatography/electrospray ionization tandem mass spectrometry | |
Jo | Rapid-Response Nitrite Probes: Intramolecular Griess Reaction for Nitrite Detection at Picogram Level | |
Branco et al. | New syntheses of DNA adducts from methylated anilines present in tobacco smoke |