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Tomitaka et al., 2000 - Google Patents

Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK‐801) injures pyramidal neurons in rat retrosplenial cortex

Tomitaka et al., 2000

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Document ID
3182677373392841772
Author
Tomitaka S
Tomitaka M
Tolliver B
Sharp F
Publication year
Publication venue
European Journal of Neuroscience

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Snippet

Non‐competitive N‐methyl‐d‐aspartate (NMDA) receptor antagonists, ketamine, phencyclidine (PCP) and dizocilpine (MK‐801), produce psychosis in people. In rodents they produce cytoplasmic vacuoles in injured retrosplenial cortical neurons that express …
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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