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Tang et al., 2016 - Google Patents

Harnessing the PEG-cleavable strategy to balance cytotoxicity, intracellular release and the therapeutic effect of dendrigraft poly-l-lysine for cancer gene therapy

Tang et al., 2016

Document ID
2716187054371307115
Author
Tang M
Dong H
Li Y
Ren T
Publication year
Publication venue
Journal of Materials Chemistry B

External Links

Snippet

Dendrimer catiomers like dendrigraft poly-L-lysine (DGL) have been very popular vectors for gene delivery recently; however, they generally suffer from serious cytotoxicity for high density of positive charge. PEGylated DGL engineered using the PEG cleavable mechanism …
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    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
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    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
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